Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: The invention concerns an oral pharmaceutical composition consisting essentially of the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and optionally of one or more pharmaceutically acceptable carriers or excipients for use in the treatment of a patient suffering from one or more progressive fibrosing interstitial lung diseases (PF-ILD), wherein this oral pharmaceutical composition is to be administered to the patient twice daily. The invention further concerns oral pharmaceutical compositions comprising the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and a therapeutically effective dose of a second active ingredient selected from nintedanib or pirfenidone, wherein these oral pharmaceutical compositions are administered to the patient twice daily.

Abstract: The invention concerns an oral pharmaceutical composition comprising either 18 mg or 9 mg of the PDE4B-inhibitor of formula III a therapeutically effective dose of a second active agent selected from the group consisting of nintedanib or pirfenidone and optionally, one or more pharmaceutically acceptable carriers or excipients for the treatment of a patient suffering from a progressive fibrosing interstitial lung disease (PF-ILD), wherein this oral pharmaceutical composition is to be administered to said patient twice daily.

Abstract: A mobile first terminal (1) has a call in progress with a second terminal (2) under a first communications service via a base station (10) of the access network of a first subsystem. A condition for transferring the call to a base station (20) of the radio access network of a second subsystem is detected in a radio network controller (11) of the first subsystem. A core network switch (12) which is linked to the radio network controller (11) of the first subsystem is informed of said detection of a call transfer condition. If the second subsystem cannot process the call under the first communications service, a service change is requested so that said call can continue under the second communications service.

Abstract: A system and method of conducting total internal reflection photoacoustic spectroscopy (TIRPAS) comprising using a pulsed laser source to emit a thermally or stress confined laser beam at a prism comprising a surface to be in contact with a sample such that the laser beam travels through the prism to a location at an interface between the prism and the sample to form an evanescent field extending into the sample to generate a detectable photoacoustic response to the evanescent field by an analyte in the sample.

Abstract: A system and method of conducting total internal reflection photoacoustic spectroscopy (TIRPAS) comprising using a pulsed laser source to emit a thermally or stress confined laser beam at a prism comprising a surface to be in contact with a sample such that the laser beam travels through the prism to a location at an interface between the prism and the sample to form an evanescent field extending into the sample to generate a detectable photoacoustic response to the evanescent field by an analyte in the sample.

Abstract: A mobile first terminal (1) has a call in progress with a second terminal (2) under a first communications service via a base station (10) of the access network of a first subsystem. A condition for transferring the call to a base station (20) of the radio access network of a second subsystem is detected in a radio network controller (11) of the first subsystem. A core network switch (12) which is linked to the radio network controller (11) of the first subsystem is informed of said detection of a call transfer condition. If the second subsystem cannot process the call under the first communications service, a service change is requested so that said call can continue under the second communications service.

Abstract: A telecommunications system 100 includes a service control point 114 storing information indicating how a telephone call should be handled. This information includes information related to a custom ringback service. An intelligent peripheral 116 has access to at least one custom ringback clip. At least one switch 104 communicates with the service control point 114 and the intelligent peripheral 116. This switch(es) 104 is configured to route the custom ringback clip (e.g., music or video) from the intelligent peripheral 116 to a caller based upon the information related to a custom ringback service stored in the service control point 114.