Abstract: The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Abstract: A network monitoring program automatically sorts fault producing locations on a network. A memory unit stores a fault location determining table containing events indicative of failures of communications via the network, the events being associated with classified elements which can be causes of faults on the network. A communication situation monitoring unit monitors communication situations with respect to other apparatus on the network. A failure detecting unit detects an event indicative of a failure from a communication situation detected by the communication situation monitoring unit. A fault location determining unit determines an element which is responsible for the event detected by the failure detecting unit by referring to the fault location determining table. A fault information output unit outputs fault information representative of a determined result from the fault location determining unit.

Abstract: There is provided an industrial production method of an aminopyrrolidine derivative having chemokine receptor antagonist activity represented by the following formula, a synthetic intermediate thereof and a production method thereof: wherein R11 is H, C1-C6 alkyl or C2-C7 alkanoyl; R12, R14, R15, R16 and R17 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy, hydroxyl or C2-C7 alkoxycarbonyl; R23, R24, R25 and R26 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy or hydroxyl; and R3 is H or C1-C6 alkyl.

Abstract: The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

Abstract: The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

Abstract: The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Abstract: The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Abstract: A network monitoring program automatically sorts fault producing locations on a network. A memory unit stores a fault location determining table containing events indicative of failures of communications via the network, the events being associated with classified elements which can be causes of faults on the network. A communication situation monitoring unit monitors communication situations with respect to other apparatus on the network. A failure detecting unit detects an event indicative of a failure from a communication situation detected by the communication situation monitoring unit. A fault location determining unit determines an element which is responsible for the event detected by the failure detecting unit by referring to the fault location determining table. A fault information output unit outputs fault information representative of a determined result from the fault location determining unit.

Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Abstract: There is provided an electric connection-inspection device which does not impair a freedom of selection of using materials from a viewpoint of restriction in terms of product's function with the aptitude of electric features of electric resistance and physical properties of internal stress, and restriction in terms of manufacture as to the appropriation or not of employment of a plating method, and which has a fine construction provided with the excellent durability that an electrode element is hard to adhere and coagulate.

Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Abstract: There is provided an electric connection-inspection device which does not impair a freedom of selection of using materials from a viewpoint of restriction in terms of product's function with the aptitude of electric features of electric resistance and physical properties of internal stress, and restriction in terms of manufacture as to the appropriation or not of employment of a plating method, and which has a fine construction provided with the excellent durability that an electrode element is hard to adhere and coagulate.

Abstract: A light-transmitting apparatus for demultiplexing an input signal completing waveform division multiplexing into wavelength components and transmitting the wavelength components through their respective transmission lines includes a wavelength-count-detecting unit for detecting the number of wavelengths of wavelength components included in the input signal and determining whether the number of wavelengths is normal or abnormal. The light-transmitting apparatus further includes a plurality of identifier-detecting units each associated with one of the wavelength components and used for determining whether or not an identifier set in one of the wavelength components that has the associated wavelength is normal, and a judgment unit for forming a judgment on existence of an error for each of the wavelength components on the basis of a detection result output by the wavelength-count-detecting unit and a detection result output by the identifier-detecting unit associated with the wavelength component.

Abstract: A nonvolatile semiconductor memory device selects a bit line while a word line is in a non-selected state, and self-selectively writes back only a cell in an overerased state on the selected bit line. The nonvolatile semiconductor memory device performs this write-back operation after completion of erase verification. At this time, current sensitivity of a sense current amplifier defining the threshold of a memory cell is set in view of an off-state leakage current of a memory cell transistor.

Abstract: A coin game machine enables a player to easily count the number of coins 23 that are paid out from a coin pay-out hole 10 of the coin game machine. Three rows of grooves 22a are formed on a receiving pan 22 of the coin game machine. The coins 23 that are paid out from the coin pay-out hole 10 are orderly lined up along each of the grooves 22a. Therefore, the player can see all the coins 23 and count the number of the coins 23 easily. In this case, by counting in advance the number of coins that can be stored in each row of the grooves 22a, the player can count the number of coins stored on the receiving pan 22 further easily.

Abstract: A nonvolatile semiconductor memory device selects a bit line while a word line is in a non-selected state, and self-selectively writes back only a cell in an overerased state on the selected bit line. The nonvolatile semiconductor memory device performs this write-back operation after completion of erase verification. At this time, current sensitivity of a sense current amplifier defining the threshold of a memory cell is set in view of an off-state leakage current of a memory cell transistor.

Abstract: A nonvolatile semiconductor memory device selects a bit line while a word line is in a non-selected state, and self-selectively writes back only a cell in an overerased state on the selected bit line. The nonvolatile semiconductor memory device performs this write-back operation after completion of erase verification. At this time, current sensitivity of a sense current amplifier defining the threshold of a memory cell is set in view of an off-state leakage current of a memory cell transistor.

Abstract: Disposed in front of the lastly stopping center reel 12B of three reels 12A, 12B, and 12C is a cover member 16 which is movable between the position of a display apparatus 108a and a shelter position thereabove and is formed with a picture Fo. When the reel 12B is stopped with its picture Fo placed at the display window 108a, in the case where each of the other two reels 12A and 12C is stopped with the picture Fo placed at the display window 108a (in the case of a jackpot), the cover member 16 is moved from the shelter position to the position of the display window 108a and minutely vibrates at the position of the display window 108a before being stopped, whereby the picture Fo' formed in the cover member 16 appears in an unusual mode. Accordingly, the player's impression when winning a jackpot in a game machine equipped with thus configured reel apparatus can be fully enhanced, thus allowing enjoyability thereof to improve.

Abstract: A coin game machine enables a player to easily count the number of coins 23 that are paid out from a coin pay-out hole 10 of the coin game machine. Three rows of grooves 22a are formed on a receiving pan 22 of the coin game machine. The coins 23 that are paid out from the coin pay-out hole 10 are orderly lined up along each of the grooves 22a. Therefore, the player can see all the coins 23 and count the number of the coins 23 easily. In this case, by counting in advance the number of coins that can be stored in each row of the grooves 22a, the player can count the number of coins stored on the receiving pan 22 further easily.