Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.

Abstract: Disclosed is a system comprising a portable electronic device, and a backend device, wherein the portable electronic device is configured to, upon occurrence of a triggering event, send a first request message to the backend device, the backend device, upon receipt of the first request message, is configured to read an internal device clock and send a first response message to the portable electronic device, wherein the first response message comprises information about the present internal device time. The portable electronic device, upon receipt of the first response message, is further configured to at least one of update an internal clock of the portable electronic device with the present internal device time, and send a second response message to an object, wherein the second response message comprises an information about the present internal device time.

Abstract: A computer-implemented device-to-device (D2D) communication method includes broadcasting, by a device, device information of the device at periodic time intervals using device-to-device (D2D) communication, receiving, by the device, the device information in an incoming new device broadcast sequence, and receiving, by the device, compiled device information in an incoming D2D broadcast sequence. The compiled device information includes device information of respective devices of a plurality of devices communicating using the D2D communication. The plurality of devices include the device and one or more additional devices. The computer-implemented method further includes storing, by the device, the compiled device information, determining, by the device, a broadcast sequence based on the compiled device information, and broadcasting, by the device, compiled device information of at least one device of the plurality of devices according to the determined broadcast sequence.

Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.

Abstract: A system and method to perform lane position sensing and tracking in a vehicle include using a first camera with a first field of view of a first side of the vehicle and a second camera with a second field of view on a second side of the vehicle to capture images. The method includes determining if a first lane line on a first side of the vehicle and a second lane line on the second side of the vehicle are both visible, and based on the first lane line and the second lane line being visible, determining, a position of the vehicle in a lane between the first lane line and the second lane line and determining a trajectory of the first lane line and the second lane line and of the vehicle.

Abstract: Circuitry comprises decode circuitry to decode program instructions including producer instructions and consumer instructions, a consumer instruction requiring, as an input operand, a result generated by execution of a producer instruction; and execution circuitry to execute the program instructions; in which: the decode circuitry is configured to control operation of the execution circuitry in response to hint data associated with a given producer instruction and indicating, for the given producer instruction, a number of consumer instructions which require, as an input operand, a result generated by the given producer instruction.

Abstract: Circuitry comprises decode circuitry to decode program instructions including producer instructions and consumer instructions, a consumer instruction requiring, as an input operand, a result generated by execution of a producer instruction; and execution circuitry to execute the program instructions; in which: the decode circuitry is configured to control operation of the execution circuitry in response to hint data associated with a given producer instruction and indicating, for the given producer instruction, a number of consumer instructions which require, as an input operand, a result generated by the given producer instruction.

Abstract: A system, apparatus and method for enabling a FIFO-like (first-in-first-out) communication between a plurality of executing processes that are distributed throughout a computing system. Embodiments exploit locality in the hierarchy of the cache memory and communication busses within the computing system to enable the passing of messages or streams of bytes with a low latency and high throughput. In addition, this allows for participating components to be very simple, or very sophisticated, but still benefit from the improved communications patterns.

Abstract: The present invention relates to novel small molecule modulators of Nav1.6 channels of the general formulae (I), (II), (III) and (IV), and the uses thereof.

Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.

Abstract: An aqueous ink composition for inkjet printing on non-porous substrates and a method for forming the same are disclosed. For example, the method includes preparing a primary polymer latex with an aromatic functional group, a hydrogen-bonding group, a flexible side-chain, and an ionic functional group and mixing the primary polymer latex with a secondary latex binder and one or more co-solvents.

Abstract: A system and method to perform lane position sensing and tracking in a vehicle include using a first camera with a first field of view of a first side of the vehicle and a second camera with a second field of view on a second side of the vehicle to capture images. The method includes determining if a first lane line on a first side of the vehicle and a second lane line on the second side of the vehicle are both visible, and based on the first lane line and the second lane line being visible, determining, a position of the vehicle in a lane between the first lane line and the second lane line and determining a trajectory of the first lane line and the second lane line and of the vehicle.

Abstract: Systems and methods are provided for controlling a lateral position of a vehicle through an intersection. The method includes receiving, by a processor, intersection data transmitted by an infrastructure associated with the intersection, the intersection data including at least a position of a plurality of lanes associated with the intersection. The method includes receiving, by the processor, a position of the vehicle, and determining, by the processor, a current lane of travel of the vehicle and a future lane of travel of the vehicle based on the intersection data and the position of the vehicle. The method includes determining, by the processor, a virtual lane through the intersection, the virtual lane providing a path of travel for the vehicle from the current lane of travel to the future lane of travel. The method includes controlling, by the processor, the vehicle based on the virtual lane.

Abstract: A system, apparatus and method for enabling a FIFO-like (first-in-first-out) communication between a plurality of executing processes that are distributed throughout a computing system. Embodiments exploit locality in the hierarchy of the cache memory and communication busses within the computing system to enable the passing of messages or streams of bytes with a low latency and high throughput. In addition, this allows for participating components to be very simple, or very sophisticated, but still benefit from the improved communications patterns.

Abstract: During “fracking” operations, proppants are used to keep open the fissures that are created, and stimulation fluids are often injected into the subterranean hydrocarbon-bearing geological formations to assist in capturing released hydrocarbons. However, because fissure surfaces formed in subterranean hydrocarbon-bearing geological formations from fracking tend to be hydrophobic, both introduced stimulation fluids and the hydrocarbons from the subterranean hydrocarbon-bearing geological formations tend to adhere to the fissure surfaces. The addition of a gemini surfactant appears to reduce the hydrophobic nature of the geological structure's fissure surfaces, thereby wetting surfaces of indigenous rock and/or introduced proppant surfaces. The addition of the gemini surfactant results in an increase of the fluid flow through the subterranean hydrocarbon-bearing geological formations, thereby enhancing of recovery of hydrocarbons and introduced stimulation fluids.

Abstract: Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.

Abstract: Staple fibers and filament yarns formed from cellulose esters, such as cellulose acetate, are described herein, along with methods of making the fibers and their use in nonwoven fabrics and articles. The filament yarns and fibers described herein may be coated with at least one finish and, in some cases, may be coated with two or more finishes selected to enhance the properties of the fibers. Staple fibers as described herein may be used to produce nonwoven webs that are strong, soft, absorbent, and biodegradable, and may be used in wet or dry nonwoven articles for a variety personal care, medical, industrial, and commercial applications.

Abstract: During “fracking” operations, proppants are used to keep open the fissures that are created, and stimulation fluids are often injected into the subterranean hydrocarbon-bearing geological formations to assist in capturing released hydrocarbons. However, because fissure surfaces formed in subterranean hydrocarbon-bearing geological formations from fracking tend to be hydrophobic, both introduced stimulation fluids and the hydrocarbons from the subterranean hydrocarbon-bearing geological formations tend to adhere to the fissure surfaces. The addition of a gemini surfactant appears to reduce the hydrophobic nature of the geological structure's fissure surfaces, thereby wetting surfaces of indigenous rock and/or introduced proppant surfaces. The addition of the gemini surfactant results in an increase of the fluid flow through the subterranean hydrocarbon-bearing geological formations, thereby enhancing of recovery of hydrocarbons and introduced stimulation fluids.

Abstract: Staple fibers and filament yarns formed from cellulose esters, such as cellulose acetate, are described herein, along with methods of making the fibers and their use in nonwoven fabrics and articles. The filament yarns and fibers described herein may be coated with at least one finish and, in some cases, may be coated with two or more finishes selected to enhance the properties of the fibers. Staple fibers as described herein may be used to produce nonwoven webs that are strong, soft, absorbent, and biodegradable, and may be used in wet or dry nonwoven articles for a variety personal care, medical, industrial, and commercial applications.

Abstract: Staple fibers and filament yarns formed from cellulose esters, such as cellulose acetate, are described herein, along with methods of making the fibers and their use in nonwoven fabrics and articles. The filament yarns and fibers described herein may be coated with at least one finish and, in some cases, may be coated with two or more finishes selected to enhance the properties of the fibers. Staple fibers as described herein may be used to produce nonwoven webs that are strong, soft, absorbent, and biodegradable, and may be used in wet or dry nonwoven articles for a variety personal care, medical, industrial, and commercial applications.