Abstract: A method for deriving a representation of an image, by processing signals corresponding to the image, comprises identifying a plurality of feature points in the image, deriving feature descriptors of feature points, and assigning feature descriptors to pre-defined centre points, wherein each feature descriptor is assigned to a plurality of centre points, the method further comprising, for each centre point, calculating the difference between each feature descriptor assigned to said centre point, deriving a value descriptor for each centre point from said calculated differences, and deriving the representation from said value descriptors for said centre points.

Abstract: The present invention provides methods, systems, assemblies, and articles for capturing single cells with a capture chip. In certain embodiments, the capture chip comprises a substrate comprising a plurality of cell-sized dimples or wells that each allow a single cell to be captured from a cell suspension. In some embodiments, the dimples or wells of the capture chip align with the holes or wells of a multi-well through-hole chip, and/or a multi-well chip, such that the cell, or the contents of the single cell, may be transferred to a corresponding well of the multi-well chip. In particular embodiments, the bottom of each dimple or well of the capture chip has a positive electrical charge sufficient to attract cells from a cell suspension flowing over the dimples or wells.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: The present invention provides methods, systems, assemblies, and articles for capturing single cells with a polymer capture film. In certain embodiments, the polymer capture films comprise a plurality of individual channels with top and bottom openings, where the channels are dimensioned such that a single cell is: i) is captured inside the channel, partially or substantially occluding the channel, when negative pressure is provided to the bottom opening; or ii) is captured by the top opening, but does not enter the channel, when negative pressure is provided to the bottom opening. In some embodiments, the channels of the polymer capture film align with the wells of a multi-well chip such that the cell, or the contents of the single cell, may be transferred to a corresponding well.

Abstract: The present invention provides methods, device, assemblies, and systems for counting and dispensing single or multiple cells (e.g., into the open wells of a multi-well testing device). In certain embodiments, the systems comprise: a) a fluid movement component composed of upstream and downstream electrode conduits connected to a non-conductive conduit, and b) an electronic signal detector electrically linked to the upstream and downstream electrode conduits such that, when a fluid is present in the fluid movement component, an electrical circuit is established that is altered when a cell passes through the non-conductive conduit. In other embodiments, the systems comprises a) a fluid movement component composed of an upstream electrode conduit connected to a non-conductive conduit, b) an in-well electrode, and c) an electronic signal detector electrically linked to the upstream electrode conduit and the in-well electrode.

Abstract: The present invention provides methods, systems, assemblies, and articles for capturing single cells with a polymer capture film. In certain embodiments, the polymer capture films comprise a plurality of individual channels with top and bottom openings, where the channels are dimensioned such that a single cell is: i) is captured inside the channel, partially or substantially occluding the channel, when negative pressure is provided to the bottom opening; or ii) is captured by the top opening, but does not enter the channel, when negative pressure is provided to the bottom opening. In some embodiments, the channels of the polymer capture film align with the wells of a multi-well chip such that the cell, or the contents of the single cell, may be transferred to a corresponding well.

Abstract: Building and maintaining an accurate and up-to-date global inventory of hardware, software, and telecommunications assets deployed throughout an organization is described. A global inventory warehouse (GIW) receives an identification and physical location of these assets from multiple source systems. Some of these source systems contain information pertaining to the assets that has been manually entered into the source system by a human administrator. Other source systems, meanwhile, contain information that has been automatically collected by the source systems without human intervention. The GIW receives this information from the source systems and stores it within a GIW database. The GIW database may thus contain a global inventory of all or nearly all of the hardware, software, and telecommunications assets distributed throughout the organization. This database may also contain an identification of physical locations within the organization of all or substantially all of these assets.

Abstract: The present invention provides methods, systems, assemblies, and articles for extracting restrained liquid (e.g., surface tension-restrained liquid) from open wells in a chip, where the restrained liquid does not flow out of the wells due to gravity when the wells are held upside down. For example, the present invention provides extraction fixtures that may be attached to, and/or held adjacent to, a chip such that any restrained liquid that is forced out of the open wells is collected by, or flows through, the extraction fixtures. Also for example, the present invention provides assemblies composed of a extraction fixture attached to, and/or held adjacent to, a chip, and methods of subjecting such assemblies to a force such that at least a portion of the restrained liquid in the open wells is forced out and collected by, or flows through, the extraction fixture.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: Building and maintaining an accurate and up-to-date global inventory of hardware, software, and telecommunications assets deployed throughout an organization is described. A global inventor warehouse (GIW) receives an identification and physical location of these assets from multiple source systems. Some of these source systems contain information pertaining to the assets that has been manually entered into the source system by a human administrator. Other source systems, meanwhile, contain information that has been automatically collected by the source systems without human intervention. The GIW receives this information from the source systems and stores it within a GIW database. The GIW database may thus contain a global inventory of all or nearly all of the hardware, software, and telecommunications assets distributed throughout the organization. This database may also contain an identification of physical locations within the organization of all or substantially all of these assets.

Abstract: The present invention relates to hard surface cleaning compositions, and their use. It is an object of the present invention to provide a hard surface cleaning composition providing hygiene to a hard surface, whilst being easily positioned onto a hard surface; even a wet surface. The present invention provides a hard surface cleaning composition, which is at least partially transparent or translucent, characterized in that it comprises a surfactant system forming a liquid crystalline phase in the presence of water and biocide material.

Abstract: The present invention relates to self adhesive hard surface cleaning blocks, and their use. It is an object of the present invention to provide a detergent block that can be easily positioned onto a hard surface; even a wet surface. It is a further object of the invention to provide a detergent block that rinses away in a number of flushes, and does not leave behind any residue that cannot be easily removed with e.g. a toilet brush. We have found that a hard surface cleaning block comprising surfactants forming a liquid crystalline phase upon contact with water meet the objects of the invention.

Abstract: A mild toilet bar composition contains C8-C18 mono and diacyl isethionates in a specified ratio in a first preferred embodiment of the invention and a specified ratio of calcium and magnesium diacyl isethionates in a second preferred embodiment of the invention. Both toilet bars provide substantial lather, mild cleansing, low mush and wear rate levels during use.

Abstract: The present invention relates to toilet cleaning blocks, and their use, in particular toilet cleaning blocks providing hygiene to a hard surface, wherein such a block is at least partially transparent or translucent appearance, in a solid, semi solid, or gel form. Accordingly the present invention provides a toilet cleaning block, which is at least partially transparent or translucent, and comprising a biocide and a carrier composition comprising soap, humectant and solvent.

Abstract: The present invention relates to hard surface cleaning compositions, and their use. It is an object of the present invention to provide a hard surface cleaning composition providing hygiene to a hard surface, whilst being easily positioned onto a hard surface; even a wet surface. The present invention provides a hard surface cleaning composition, which is at least partially transparent or translucent, characterized in that it comprises a surfactant system forming a liquid crystalline phase in the presence of water and biocide material.

Abstract: Building and maintaining an accurate and up-to-date global inventory of hardware, software, and telecommunications assets deployed throughout an organization is described. A global inventory warehouse (GIW) receives an identification and physical location of these assets from multiple source systems. Some of these source systems contain information pertaining to the assets that has been manually entered into the source system by a human administrator. Other source systems, meanwhile, contain information that has been automatically collected by the source systems without human intervention. The GIW receives this information from the source systems and stores it within a GIW database. The GIW database may thus contain a global inventory of all or nearly all of the hardware, software, and telecommunications assets distributed throughout the organization. This database may also contain an identification of physical locations within the organization of all or substantially all of these assets.

Abstract: Reconciling corresponding data reported by multiple data sources and pertaining to hardware, software, and telecommunications assets distributed throughout an organization is described. In one aspect, a reconciliation framework receives data maintained by a first data source and pertaining to a portion of the hardware, software, and telecommunications assets distributed throughout the organization. The reconciliation framework then also receives data maintained by a second data source and pertaining to the portion of the hardware, software, and telecommunications assets distributed throughout the organization. The reconciliation framework then compares the data maintained by the first data source to the data maintained by the second data source effective to determine differences between the data maintained by the first data source and the data maintained by the second data source.