Patents by Inventor Syed M. Shah

Syed M. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Floating Zinc Gastric Delivery Compositions
    Publication number: 20170319476
    Abstract: A composition includes a therapeutically effective oral pharmaceutical dosage form that becomes buoyant upon contact with gastric fluid. The dosage form includes an active ingredient combination including an amino acid source and a zinc source, an anionic polymer, an effervescent agent, and a pH buffer. The dosage form is effective for releasing the active ingredient combination while buoyant on gastric fluid.
    Type: Application
    Filed: May 4, 2017
    Publication date: November 9, 2017
    Applicant: Physician's Seal, LLC
    Inventors: Daniel Hassan, Syed M. Shah, Fred Hassan, Christopher Diorio
  • Multiparticulate L-Menthol Formulations and Related Methods
    Publication number: 20170266125
    Abstract: A pharmaceutical dosage form includes an effective amount of L-menthol for treating a gastrointestinal disorder. The L-menthol is within a plurality of particulates having a core including crystalline L-menthol dissolved in a terpene-based essential oil. A proteinaceous coating of a continuous film of proteinaceous material is over the core.
    Type: Application
    Filed: June 6, 2017
    Publication date: September 21, 2017
    Inventors: Syed M. Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
  • TIGECYCLINE COMPOSITIONS AND METHODS OF PREPARATION
    Publication number: 20170266290
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: June 5, 2017
    Publication date: September 21, 2017
    Applicant: Wyeth LLC
    Inventors: Mahdi B. FAWZI, Tianmin ZHU, Syed M. SHAH
  • Multiparticulate L-Carnitine And Nootropic Compositions And Related Methods
    Publication number: 20170231940
    Abstract: A composition includes a therapeutically effective pharmaceutical dosage form including a plurality of individual particulates. The individual particulates respectively have: a core including an active ingredient combination of an L-carnitine and a nootropic substance and a release controlling polymer over the core that substantially prevents release of the active ingredients in stomach acid and permits release of the active ingredients in an intestinal pH environment. The composition may be used to treat conditions associated with a reduction of the amount of L-carnitine in the body and/or cognitive impairment.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Applicant: Physician's Seal, LLC
    Inventors: Syed M. Shah, Noreen Hassan, Christopher Diorio, Fred Hassan
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9724343
    Abstract: The present invention provides a compound of formua I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: August 8, 2017
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Enteric coated multiparticulate composition with proteinaceous coating for improved storage stability
    Patent number: 9717696
    Abstract: A storage stable L-menthol composition includes a tablet, caplet, capsule, or sachet dosage form. The dosage form has (a) a plurality of individual cores containing an L-menthol source and at least one pharmaceutical excipient and (b) a proteinaceous coating of a continuous film of proteinaceous material over the individual cores forming a plurality of proteinaceous coated individual cores. The film is effective to substantially prevent L-menthol in the L-menthol source from leaving the individual cores when stored at a temperature of 40 degrees C. and 75% relative humidity for at least 1 day. The dosage form contains an effective amount of the L-menthol source for treating a gastrointestinal disorder.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: August 1, 2017
    Assignee: ZxPharma, LLC
    Inventors: Syed M. Shah, Fred Hassan
  • Enteric coated multiparticulate controlled release peppermint oil composition and related methods
    Patent number: 9707260
    Abstract: A multiparticulate composition is formed from a plurality of individual cores including a hydrophobic phase containing peppermint oil dispersed in a microcrystalline cellulose-based gel and a hydrophilic phase containing a hydrogel. An enteric coating is over the individual cores. The multiparticulate composition can be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: July 18, 2017
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Daniel Hassan, Fred Hassan
  • Tigecycline compositions and methods of preparation
    Patent number: 9694078
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 4, 2017
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • Preventing whisker growth from an L-menthol composition
    Patent number: 9668982
    Abstract: A pharmaceutical dosage form includes an effective amount of L-menthol for treating a gastrointestinal disorder. The L-menthol is within a plurality of particulates having a core including crystalline L-menthol dissolved in a terpene-based essential oil. A proteinaceous coating of a continuous film of proteinaceous material is over the core.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: June 6, 2017
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
  • Controlled-Release Melatonin Compositions and Related Methods
    Publication number: 20170128419
    Abstract: An oral melatonin pharmaceutical dosage form that contains a sustained release dose of melatonin includes melatonin and an acid dispersed in a hydrogel-forming polymer matrix that combine after ingestion to form an acidic hydrogel containing the melatonin. The dosage form is effective to release melatonin therefrom for at least six hours after oral ingestion.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Inventors: Syed M. Shah, Daniel Hassan
  • Controlled-Release Compositions of Melatonin Combined with Sedative and/or Analgesic Ingredients
    Publication number: 20170079919
    Abstract: Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.
    Type: Application
    Filed: December 7, 2016
    Publication date: March 23, 2017
    Inventors: Syed M. Shah, Daniel Hassan, Christopher Diorio, Fred Hassan
  • Enteric coated multiparticulate composition with proteinaceous subcoat
    Patent number: 9572782
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: February 21, 2017
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Fred Hassan
  • Controlled-release melatonin compositions and related methods
    Patent number: 9549900
    Abstract: A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: January 24, 2017
    Assignee: Physician's Seal, LLC
    Inventors: Syed M. Shah, Daniel Hassan
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20170007597
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 26, 2016
    Publication date: January 12, 2017
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
    Patent number: 9532952
    Abstract: Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: January 3, 2017
    Assignee: Physician's Seal, LLC
    Inventors: Syed M. Shah, Daniel Hassan, Christopher Diorio, Fred Hassan
  • FORMULATIONS FOR PARENTERAL DELIVERY OF COMPOUNDS AND USES THEREOF
    Publication number: 20160338946
    Abstract: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
    Type: Application
    Filed: May 19, 2016
    Publication date: November 24, 2016
    Applicant: Wyeth, LLC
    Inventors: Syed M. Shah, Christian Ofslager, Mahdi B. Fawzi, Nataliya Bazhina
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9492445
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 15, 2016
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Enteric Coated Multiparticulate Controlled Release Peppermint Oil Composition and Related Methods
    Publication number: 20160324913
    Abstract: A multiparticulate composition is formed from a plurality of individual cores including a hydrophobic phase containing peppermint oil dispersed in a microcrystalline cellulose-based gel and a hydrophilic phase containing a hydrogel. An enteric coating is over the individual cores. The multiparticulate composition can be used to treat gastrointestinal disorders.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: Syed M. Shah, Daniel Hassan, Fred Hassan
  • Controlled-Release Compositions of Melatonin Combined with Sedative and/or Analgesic Ingredients
    Publication number: 20160243038
    Abstract: Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.
    Type: Application
    Filed: May 6, 2016
    Publication date: August 25, 2016
    Inventors: Syed M. Shah, Daniel Hassan, Christopher Diorio, Fred Hassan
  • ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE
    Publication number: 20160206612
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Application
    Filed: March 15, 2016
    Publication date: July 21, 2016
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen