Patents by Inventor Syed M. Shah

Syed M. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE
    Publication number: 20160206612
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Application
    Filed: March 15, 2016
    Publication date: July 21, 2016
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen
  • Enteric coated multiparticulate controlled release peppermint oil composition and related methods
    Patent number: 9393279
    Abstract: A multiparticulate composition is formed from a plurality of individual cores including a hydrophobic phase containing peppermint oil dispersed in a microcrystalline cellulose-based gel and a hydrophilic phase containing a hydrogel. An enteric coating is over the individual cores. The multiparticulate composition can be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: July 19, 2016
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Daniel Hassan, Fred Hassan
  • TIGECYCLINE COMPOSITIONS AND METHODS OF PREPARATION
    Publication number: 20160144036
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: Wyeth LLC
    Inventors: Mahdi B. FAWZI, Tianmin ZHU, Syed M. SHAH
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20160113923
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 30, 2015
    Publication date: April 28, 2016
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Oral formulations and lipophilic salts of methylnaltrexone
    Patent number: 9314461
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: April 19, 2016
    Assignee: Wyeth, LLC
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen
  • Multiparticulate L-Menthol Formulations and Related Methods
    Publication number: 20160095822
    Abstract: A pharmaceutical dosage form includes an effective amount of L-menthol for treating a gastrointestinal disorder. The L-menthol is within a plurality of particulates having a core including crystalline L-menthol dissolved in a terpene-based essential oil. A proteinaceous coating of a continuous film of proteinaceous material is over the core.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 7, 2016
    Inventors: Syed M. Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
  • Controlled-Release Melatonin Compositions and Related Methods
    Publication number: 20160067186
    Abstract: A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Inventors: Syed M. Shah, Daniel Hassan
  • CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF
    Publication number: 20160068540
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 10, 2016
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • Enteric Coated Multiparticulate Composition With Proteinaceous Coating For Improved Storage Stability
    Publication number: 20160038429
    Abstract: A storage stable L-menthol composition includes a tablet, caplet, capsule, or sachet dosage form. The dosage form has (a) a plurality of individual cores containing an L-menthol source and at least one pharmaceutical excipient and (b) a proteinaceous coating of a continuous film of proteinaceous material over the individual cores forming a plurality of proteinaceous coated individual cores. The film is effective to substantially prevent L-menthol in the L-menthol source from leaving the individual cores when stored at a temperature of 40 degrees C. and 75% relative humidity for at least 1 day. The dosage form contains an effective amount of the L-menthol source for treating a gastrointestinal disorder.
    Type: Application
    Filed: October 20, 2015
    Publication date: February 11, 2016
    Inventors: Syed M. Shah, Fred Hassan
  • Tigecycline compositions and methods of preparation
    Patent number: 9254328
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: February 9, 2016
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • L-Menthol Dosage Forms Having A Proteinaceous Coating For Enhanced Storage Stability
    Publication number: 20160022597
    Abstract: A storage stable L-menthol composition including a tablet, caplet, capsule, or sachet dosage form has therein a core containing crystalline L-menthol and at least one pharmaceutical excipient. A proteinaceous coating of a continuous film of proteinaceous material is over the core. The film is effective to substantially prevent the crystalline L-menthol from volatilizing and leaving the core when stored at a temperature of 40 degrees C. and 75% relative humidity from between 1 day to 30 days. The dosage form contains an effective amount of the crystalline L-menthol for treating a gastrointestinal disorder.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Inventors: Syed M. Shah, Fred Hassan
  • BIOADHESIVE AND BIODEGRADABLE AND FORMULATIONS THAT PROVIDE SUSTAINED RELEASE OF ANTIMICROBIALS, BACTERIOPHAGES AND ANTI-INFLAMMATORY MEDICATIONS FOR INACTIVATION OF BIOFILMS AND THE TREATMENT OF RHINOSINUSITIS AND OTHER INFECTIONS
    Publication number: 20160022595
    Abstract: Described is a composition comprising one or more active ingredients coated, dispersed, or dissolved with a mucoadhesive polymer. Although subject to multiple uses, the composition, in some embodiments, is usable for treating rhinosinusitis.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 28, 2016
    Inventors: Alan H. Shikani, Abraham Domb, Fred Hassan, Syed M. Shah
  • Multiparticulate L-Menthol Formulations and Related Methods
    Publication number: 20160000728
    Abstract: An L-menthol pharmaceutical dosage form includes an effective amount of L-menthol for treating a gastrointestinal disorder. The L-menthol is within a plurality of particulates having a core and an enteric coating over the core. The core includes an L-menthol source that is at least 80% pure L-menthol. The dosage form may be used to treat gastrointestinal disorders, such as irritable bowel syndrome.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Syed M. Shah, Daniel Hassan
  • Multiparticulate L-menthol formulations and related methods
    Patent number: 9220686
    Abstract: A multiparticulate dosage form includes a plurality of individual spheroidal enteric coated particulates having (a) a diameter of 0.1 to 2.5 mm; (b) a solid core containing an effective amount of a combination of an L-menthol source and a terpene-based essential oil; (c) a continuous proteinaceous subcoating over the core; and (d) an enteric coating over the subcoating. The multiparticulate dosage form can be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 29, 2015
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
  • Enteric coated multiparticulate composition with proteinaceous subcoat
    Patent number: 9192583
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: November 24, 2015
    Assignee: Zx Pharma, LLC
    Inventors: Syed M. Shah, Fred Hassan
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9180125
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 10, 2015
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
    Patent number: 9102680
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: August 11, 2015
    Assignees: Wyeth LLC, Progenics Pharmamceuticals, Inc.
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20150150866
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: July 2, 2014
    Publication date: June 4, 2015
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • TIGECYCLINE COMPOSITIONS AND METHODS OF PREPARATION
    Publication number: 20150141379
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • Tigecycline compositions and methods of preparation
    Patent number: 8975242
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: March 10, 2015
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah