Patents by Inventor Sylvain Rault
Sylvain Rault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230404973Abstract: The invention concerns a compound of formula (I), Formula (I), R, R1 and R2 are independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carboxyl group, —an amido group comprising from 1 to 10 carbon atoms, and —an imino group, possibly substituted by an alkyl group, linear, cyclic or branched, saturated or unsaturated, and wherein R3, R4, R5 and R6 are independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —a hydroxyl group, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an alkoxy group comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carbonate group from 1 to 10 carbon atoms, —a carboxyl group, and —a cyano group.Type: ApplicationFiled: October 12, 2020Publication date: December 21, 2023Inventors: Laurence LAFANECHÈRE, Renaud PRUDENT, Lauralie PERONNE, Marc BILLAUD, Audrey VERNET, Eric DENARIER, Patrick DALLEMAGNE, Sylvain RAULT, Peggy SUZANNE, Jean-charles LANCELOT, Serge PERATO, Aurélien LESNARD
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Publication number: 20220009884Abstract: The invention relates to compounds of formula (I) as follows: (I) wherein X1 and X2, identical or different, are NR5 or a sulfur atom, Y is a group (C1-C10)alkanediyl, Ar1 and Ar2, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3? with R1 and R2, independently of each other, are a hydrogen atom, a (C-1-C6) alkyl group or a —COR3 group, R3 and R4? independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and R5 is a hydrogen atom or a (C1-C6)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.Type: ApplicationFiled: November 28, 2019Publication date: January 13, 2022Inventors: Marc BILLAUD, Renaud PRUDENT, Martine CORDIER-BUSSAT, Eric FONTAINE, Patrick DALLEMAGNE, Peggy SUZANNE, Sylvain RAULT
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Publication number: 20210337789Abstract: The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.Type: ApplicationFiled: July 2, 2019Publication date: November 4, 2021Applicants: Universite de Caen Normandie, LABEOInventors: Sylvain Rault, Christophe Rochais, Stéphane Lemaitre, Feng Xiao, Peggy Suzanne, Patrick Dallemagne, Sophie Castagnet, Albertine Leon-Seck
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Patent number: 10307410Abstract: The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer: Wherein Y1, Y2, Ar1, Ar2, R1, R2, i, j, k, l are as defined in claim 1.Type: GrantFiled: March 3, 2015Date of Patent: June 4, 2019Assignees: CENTRE REGIONAL DE LUTTE CONTRE LE CANCER FRANCOIS BACLESSE, UNIVERSITE DE CAEN BASSE-NORMANDIE, INSTITUT DE CANCEROLOGIE DE L'OUEST RENE GAUDUCHEAUInventors: Laurent Poulain, Anne-Sophie Voisin-Chiret, Jana Sopkova-de Oliveira Santos, Ronan Bureau, Grégory Burzicki, Marcella De Giorgi, Serge Perato, Jade Fogha, Sylvain Rault, Philippe Juin, Fabien Gautier
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Publication number: 20170071921Abstract: The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer: Wherein Y1, Y2, Ar1, Ar2, R1, R2, i, j, k, l are as defined in claim 1.Type: ApplicationFiled: March 3, 2015Publication date: March 16, 2017Applicants: CENTRE REGIONAL DE LUTTE CONTRE LE CANCER FRANCOIS BACLESSE, UNIVERSITE DE CAEN BASSE-NORMANDIE, INSTITUT DE CANCEROLOGIE DE L'OUEST RENE GAUDUCHEAUInventors: Laurent POULAIN, Anne-Sophie VOISIN-CHIRET, Jana SOPKOVA-DE OLIVEIRA SANTOS, Ronan BUREAU, Grégory BURZICKI, Marcella DE GIORGI, Serge PERATO, Jade FOGHA, Sylvain RAULT, Philippe JUIN, Fabien GAUTIER
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Patent number: 8853276Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.Type: GrantFiled: September 6, 2011Date of Patent: October 7, 2014Assignee: Produits Chimiques Auxiliaires et de SyntheseInventors: Sylvain Rault, Jean Charles Lancelot, Peggy Suzanne, Anne-Sophie Voisin-Chiret, Regis Pecquet, Jean-Christophe Joseph
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Publication number: 20130165507Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.Type: ApplicationFiled: September 6, 2011Publication date: June 27, 2013Applicant: PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESEInventors: Sylvain Rault, Jean Charles Lancelot, Peggy Suzanne, Anne-Sophie Voisin-Chiret, Regis Pecquet, Jean-Christophe Joseph
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Publication number: 20110065782Abstract: The present invention relates to methods of identifying compounds that inhibit the activation between a biomolecule, pharmaceutical compositions comprising such compounds, and methods of treating and/or to reducing the risk of Bacillus anthracis and Bordetella pertussis infection by administering such pharmaceutical compositions.Type: ApplicationFiled: September 15, 2009Publication date: March 17, 2011Inventors: Thérèse Malliavin, Elodie Laine, Arnaud Blondel, Daniel Ladant, Johanna Karst, Sylvain Rault, Aurélien Lesnard
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Patent number: 7361662Abstract: A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as kinase modulators.Type: GrantFiled: November 4, 2003Date of Patent: April 22, 2008Assignee: Les Laboratoires ServierInventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Pierre Renard
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Patent number: 7098220Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, R2 represents hydrogen, alkyl, an optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein: R20 represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl, X represents oxygen, sulphur, or NR21 wherein R21 represents hydrogen or alkyl, R3 represents hydrogen atom or alkyl, n represents integer from 1 to 6 inclusive, the representation its enantiomers, diastereoisomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as AMPK activators.Type: GrantFiled: November 4, 2003Date of Patent: August 29, 2006Assignee: Les Laboratoires ServierInventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Jean-Guy Bizot-Espiard, Pierre Renard
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Publication number: 20060069117Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, R2 represents hydrogen, alkyl, an optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein: R20 represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl, X represents oxygen, sulphur, or NR21 wherein R21 represents hydrogen or alkyl, R3 represents hydrogen atom or alkyl, n represents integer from 1 to 6 inclusive, the representation its enantiomers, diastereoisomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as AMPK activators.Type: ApplicationFiled: November 4, 2003Publication date: March 30, 2006Inventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Jean-Guy Bizot-Espiard, Pierre Renard
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Publication number: 20060019995Abstract: A compound selected from those of formula (I): wherein: R1 represents hydrogen, aryl(C1-C6)alkyl, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, aryl(C1-C6)alkoxycarbonyl, or trifluoroacetyl, R2 represents hydrogen, linear or branched (C1-C6)alkyl, X represents oxygen or NOR3, R3 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more identical or different groups selected from hydroxy, amino and linear or branched (C1-C6)alkoxy, Ar represents aryl or heteroaryl, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cognitive disorders and which possess antalgic properties.Type: ApplicationFiled: November 4, 2003Publication date: January 26, 2006Inventors: Sylvain Rault, Nicolas Leflemme, Patrick Dallemagne, Pierre Lestage, Brian Lockhart, Laurence Danober, Bruno Pfeiffer, Pierre Renard
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Publication number: 20050288311Abstract: A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as kinase modulators.Type: ApplicationFiled: November 4, 2003Publication date: December 29, 2005Inventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Pierre Renard
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Publication number: 20050143440Abstract: Compounds of formula (I): wherein: R1 represents an optionally substituted heteroaryl group, R2 represents an optionally substituted cycloalkyl group, R3 represents a hydrogen atom or an alkyl group, and R4 and R5 are as defined in the description, and Medicinal products containing the same are useful in the treatment of non-insulin-dependent type II diabetes, obesity, type I diabetes, hyperlipidaemia, hypercholesterolaemia and cardiovascular complications thereof.Type: ApplicationFiled: March 1, 2005Publication date: June 30, 2005Applicant: LES LABORATORIES SERVIERInventors: Sylvain Rault, Marina Kopp, Jean-Charles Lancelot, Stephane Lemaitre, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
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Patent number: 6875788Abstract: Compounds of formula (I): wherein: R1 represents an optionally substituted heteroaryl group, R2 represents an optionally substituted cycloalkyl group, R3 represents a hydrogen atom or an alkyl group, and R4 and R5 are as defined in the description, and Medicinal products containing the same are useful in the treatment of non-insulin-dependent type II diabetes, obesity, type I diabetes, hyperlipidaemia, hypercholesterolaemia and cardiovascular complications thereof.Type: GrantFiled: October 20, 2003Date of Patent: April 5, 2005Assignee: Les Laboratoires ServierInventors: Sylvain Rault, Marina Kopp, Jean-Charles Lancelot, Stéphane Lemaitre, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
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Publication number: 20040087638Abstract: Compounds of formula (I): 1Type: ApplicationFiled: October 20, 2003Publication date: May 6, 2004Inventors: Sylvain Rault, Marina Kopp, Jean-Charles Lancelot, Stephane Lemaitre, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
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Patent number: 6451789Abstract: Compound of formula (I): wherein: n represents 0 or 1, R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl, R2 represents alkyl, X represents oxygen, chlorine, OR3, SR4 or NOR5, R3 represents hydrogen , alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl, R4 represents hydrogen, alkyl or aryl, R5 represents hydrogen or optionally substituted alkyl, represents a single or double bond, Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.Type: GrantFiled: September 26, 2001Date of Patent: September 17, 2002Assignee: Les Labortoires ServierInventors: Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cécile Lebrun
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Publication number: 20020042413Abstract: Compound of formula (I): 1Type: ApplicationFiled: September 26, 2001Publication date: April 11, 2002Inventors: Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cecile Lebrun
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Patent number: 6346650Abstract: The invention concerns a method consisting in making a mixed (meth)acrylic anhydride of formula (I) by reacting an alkaline (meth)acrylate of formula (II) and a chloroformate of formula (III), carrying out said reaction in an aqueous medium and in the absence of amines, the mol ratio chloroformate (III)/alkaline (meth)acrylate (II) being at least equal to 1.15. R1 represents H or CH3; R2 represents an alkyl, alkenyl, aryl, alkaryl or aralkyl residue; and M is an alkaline metal.Type: GrantFiled: July 31, 2000Date of Patent: February 12, 2002Assignee: AtofinaInventors: Jean-Michel Paul, Alain Riondel, Frédéric Fabis, Sylvain Rault
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Patent number: 6323222Abstract: Compound of formula (I): wherein: n represents 0 or 1, R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl, R2 represents alkyl, X represents oxygen, chlorine, OR3, SR4 or NOR5, R3 represents hydrogen, alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl, R4 represents hydrogen, alkyl or aryl, R5 represents hydrogen or optionally substituted alkyl, represents a single or double bond, Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.Type: GrantFiled: May 2, 2000Date of Patent: November 27, 2001Assignee: Adir et CompagnieInventors: Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cécile Lebrun