Abstract: The present invention relates to compositions and methods for molecular profiling and diagnostics for genetic disorders and cancer, including but not limited to gene expression product markers associated with cancer or genetic disorders. In particular, the present invention provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Abstract: Systems, methods, and non-transitory computer-readable storage media are provided. A central server receives collateral data and applies a set of collateral analysis rules thereto to identify a problem. The applying includes accessing, from a remote data source, supplemental data related to the collateral data, and detecting one or more differences exceeding discrepancy tolerances between the collateral data and the supplemental data. The central server generates a notification including descriptions of the problem and the collateral data, and a navigation link to access more information from a source of problem information related to the collateral data. The central server transmits the notification to a remote computing device based upon a remote computing device destination address.

Abstract: The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Abstract: An autonomous surface vessel includes an elongate body, and a sampling system operatively coupled to the body and including one or more sampling modules, wherein each sampling module includes a housing including a storage container, a sampling material receivable within the storage container, an actuation system operatively coupled to the sampling material via a lead line, and an end cap operatively coupled to the lead line and matable with an open end of the storage container. A computer system is in communication with the sampling system to operate the actuation system, wherein each sampling module is actuatable between a stowed state, where the sampling material is received within the storage container and the end cap sealingly engages the open end, and a deployed state, where the end cap is disengaged from the open end and the sampling material is drawn out of the sampling container.

Abstract: The present invention is directed to methods of controlling oomycetes comprising applying one or more cervinomycins. The present invention is further directed to methods of controlling particular fungi comprising applying one or more cervinomycins.

Abstract: In one aspect, the disclosure relates to a super high frequency (SHF) or extremely high frequency (EHF) bulk acoustic resonator that includes a nanostructure, wherein the nanostructure includes a substrate, a three-dimensional structure disposed on the substrate, wherein the three-dimensional structure includes a planar structure including at least one nanocomponent and a matrix material contacting the nanocomponent on at least one side, the matrix material including an SiGe alloy or Ge. The disclosed bulk acoustic resonator operates at frequencies of from about 100 MHz to about 100 GHz, is capable of self-amplification upon application of direct current or voltage, and has a Q factor amplification exceeding 1. Also disclosed are methods for amplification of mechanical resonance in the disclosed bulk acoustic resonators and devices incorporating the bulk acoustic resonators.

Abstract: Methods for identifying hydrocarbon contamination sources may include fingerprinting hydrocarbons using isotopocule analyses for BTEX compounds. For example, methods for identifying hydrocarbon contamination sources may comprise: extracting BTEX compounds from a sample; measuring the isotopocule composition of the BTEX compounds; and determining a characteristic of the sample based on the isotopocule composition. Such characteristics may include, but are not limited to, the characteristic of the sample comprises one or more selected from the group consisting of: a source of the sample, a condition at which the sample formed or was last equilibrated, a migration time from a source to a sample location, weathering of the sample, and degree to which the sample is anthropogenic and naturally-occurring.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: A quantitative simulation process for producing quantitative model predictions of hydrocarbon composition. The quantitative simulation may include measuring a chemical and isotopic composition of a hydrocarbon sample from a hydrocarbon reservoir.

Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.

Abstract: Systems, methods, and products communicate loan collateral information. A central server receives collateral data that is filtered based on collateral identification information. A problem in the filtered collateral data is identified by applying a set of collateral analysis rules and accessing related supplemental data to detect one or more differences between the filtered collateral data and the supplemental data. A notification is generated that includes descriptions of the problem and the filtered collateral data, and a navigation link to access more information from a source of problem information. The notification is transmitted to a remote computing device based on a destination address, including an internet protocol address. The notification is in a format compatible with the remote computing device.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: The present invention is directed to a method of controlling a pest comprising applying an effective amount of one or more terpendoles to the pest or an area in need of pest control. The present invention is further directed to a method of controlling a pest comprising applying an effective amount of one or more compounds having the following chemical structure to the pest or an area in need of pest control.

Abstract: Systems and methods for detecting, capturing and/or disinfecting viruses. A water trap system includes a water-filled container through which air is introduced into a water-filled container. Charged viruses, bacteria and other contaminants become trapped in the water-filled container as they are entrapped by oppositely charged atoms (e.g., oxygen). Another device incorporates an electric field created by a pair of electrodes with an outer surface heated to a threshold temperature significant enough to disinfect viruses that come into contact therewith. Another device is a portable inhaler for detecting the polarity of airborne viruses and counting the positive and negative electrical charges of airborne viruses with tolerances of a few charged particles per cubic centimeter by sampling several hundred cubic centimeters of air per second. Consequently, the portable inhaler is capable of quickly and efficiently detecting whether a person has contracted a virus (e.g., COVID-19 virus).

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: In a method of atomic precision advanced manufacturing (APAM), an atomic or molecular resist layer on a substrate surface is selectively depassivated by locally exciting the substrate surface with an optical beam effective to eject adsorbed atoms or molecules from the substrate surface. The substrate surface is further processed by exposing it to a precursor gas, decomposing the precursor gas to release a dopant, and incorporating the dopant into the substrate surface.

Abstract: An adapter system for facilitating collection of colostrum from a breast may include an adapter, a removable reservoir and a hand-expression funnel. The adapter may include a first open end for connecting to a breast shield of a breast pump system, a second open end for connecting to a breast pump connector of the breast pump system, and a third open end, disposed between the first and second open ends. The removable reservoir may include a wide end for removably attaching to the third open end and a narrow end for attaching to a colostrum delivery device. The hand-expression funnel may include a wide end for receiving colostrum and a narrow end for attaching to the colostrum delivery device. In some embodiments, the colostrum delivery device is a syringe.