Patents by Inventor Taco Gilles Uil

Taco Gilles Uil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cold-adapted-viral-attenuation (CAVA) and novel attenuated poliovirus strains
    Patent number: 10238730
    Abstract: A poliovirus (PV) strain was attenuated by a novel method of Cold-Adapted-Viral-Attenuation (CAVA). The resulting recombinant attenuated PV, CAVA-PV, shows wild-type replication at 30° C., but no substantial replication at 37° C. The inability to replicate at 37° C. is defined by an inability to quantify virus during infection at this temperature by titration (infectious units), qPCR (viral RNA) or Electron Microscopy (visual signs of infection). CAVA-PV is genetically stable under production conditions and shows utility for use as the backbone to produce attenuated strains with the same antigenic profile as conventional vaccines by replacing the sequence coding for the capsid of CAVA-PV with sequences coding for capsids of different PV strains. Furthermore, mutations identified in CAVA-PV can be engineered into different, even wild-type and neurovirulent poliovirus background strains to obtain additional CAVA-PV strains.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 26, 2019
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Barbara Petronella Sanders, Jerome Hubertina Henricus Victor Custers, Diana Edo-Matas, Taco Gilles Uil, John A. Lewis
  • THERAPEUTIC HPV16 VACCINES
    Publication number: 20180344841
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: August 8, 2018
    Publication date: December 6, 2018
    Inventors: Evelien Margaretha Bunnik, Jerôme Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • Therapeutic HPV16 vaccines
    Patent number: 10071151
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: September 11, 2018
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Evelien M. Bunnik, Jerome H. H. V. Custers, Gerrit C. Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • POTENT AND SHORT PROMOTER FOR EXPRESSION OF HETEROLOGOUS GENES
    Publication number: 20180223314
    Abstract: The invention provides an AoHV-1 promoter for use with plasmid vectors, viral vectors, viruses, and cell lines comprising the AoHV-1 promoter operably linked to a transgene. The invention also provides methods of making and using recombinant plasmid vectors, viral vectors, viruses, and cell lines comprising the AoHV-1 promoter operably linked to a transgene.
    Type: Application
    Filed: February 8, 2018
    Publication date: August 9, 2018
    Inventors: Kerstin WUNDERLICH, Taco Gilles UIL, Jort VELLINGA, Barbara Petronella SANDERS, Remko VAN DER VLUGT
  • THERAPEUTIC HPV18 VACCINES
    Publication number: 20170369534
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Application
    Filed: September 12, 2017
    Publication date: December 28, 2017
    Inventors: Evelien M. BUNNIK, Jerome Hubertina Henricus Victor CUSTERS, Gerrit C. SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN
  • Therapeutic HPV18 vaccines
    Patent number: 9790256
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 17, 2017
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Evelien Margaretha Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • THERAPEUTIC HPV16 VACCINES
    Publication number: 20170281747
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 5, 2017
    Inventors: Evelien M. BUNNIK, Jerome H.H.V. CUSTERS, Gerrit C. SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN
  • Therapeutic HPV16 vaccines
    Patent number: 9701721
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: July 11, 2017
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Evelien Margaretha Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • COLD-ADAPTED-VIRAL-ATTENUATION (CAVA) AND NOVEL ATTENUATED POLIOVIRUS STRAINS
    Publication number: 20170087240
    Abstract: A poliovirus (PV) strain was attenuated by a novel method of Cold-Adapted-Viral-Attenuation (CAVA). The resulting recombinant attenuated PV, CAVA-PV, shows wild-type replication at 30° C., but no substantial replication at 37° C. The inability to replicate at 37° C. is defined by an inability to quantify virus during infection at this temperature by titration (infectious units), qPCR (viral RNA) or Electron Microscopy (visual signs of infection). CAVA-PV is genetically stable under production conditions and shows utility for use as the backbone to produce attenuated strains with the same antigenic profile as conventional vaccines by replacing the sequence coding for the capsid of CAVA-PV with sequences coding for capsids of different PV strains. Furthermore, mutations identified in CAVA-PV can be engineered into different, even wild-type and neurovirulent poliovirus background strains to obtain additional CAVA-PV strains.
    Type: Application
    Filed: June 16, 2015
    Publication date: March 30, 2017
    Inventors: Barbara Petronella Sanders, Jerome Hubertina Henricus Victor Custers, Diana Edo-Matas, Taco Gilles Uil, John A. Lewis
  • THERAPEUTIC HPV18 VACCINES
    Publication number: 20170051019
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Application
    Filed: August 19, 2016
    Publication date: February 23, 2017
    Inventors: Evelien Margaretha Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • THERAPEUTIC HPV16 VACCINES
    Publication number: 20160122396
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Evelien Margaretha Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan