Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.

Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.

Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.

Abstract: It is an object of the present invention to provide an amplifier apparatus which can amplify the sound signal at a relatively high quality, and to provide an acoustic system comprising the amplifier apparatus. The amplifier apparatus comprises a first amplifier 13 having a first acoustic gain, and being adapted to amplify an analog sound signal according to the first acoustic gain, and to allow the first acoustic gain to be changed, an analog-to-digital converter 14 for converting the amplified analog sound signal to a digital sound signal, a second amplifier 15 having an second acoustic gain, being adapted to amplify the digital sound signal according to the second acoustic gain, and to allow the second acoustic gain to be changed, and a controller 16 for obtaining a combined acoustic gain from the first and second acoustic gains, and keeping the combined acoustic gain constant by modifying the second acoustic gain in response to a change of the first acoustic gain.

Abstract: It is an object of the present invention to provide an audio mixer which can specify and inform whether or not each of the audio signals exceeds a threshold level, without switching to each group. The audio mixer includes: group selecting means 3 for selecting one group from among groups having audio signals allocated thereto; level information display means 4 for displaying level information indicative of signal levels of the audio signals of the one group selected by the group selecting means 3; signal level judging means 6 for judging whether or not each of the audio signals of the groups is a larger than a threshold level; and peak information display means 7 for displaying peak information of each audio signal, the peak information being indicative of the judgment made by the signal level judging means 6.

Abstract: An audio signal adjusting apparatus for adjusting raw audio signals to produce adjusted audio signals, comprises an audio signal adjusting unit for adjusting the raw audio signals and operably connected with loudspeakers for producing audio sounds that collectively originated from an imaginary sound source. The imaginary sound source is imagined to produce the audio sounds at a location spaced apart from each of the loudspeakers. A controlling unit allows each of the raw audio signals to be adjusted in response to a location control signal indicative of the location of the imaginary sound source. A pointer image producing unit produces a pointer image indicative of the location of the imaginary sound source. A superimposing unit is designed to superimpose the pointer image on a portion of a screen image after receiving a video signal from a video signal producing unit in response to the location control signal.

Abstract: Herein disclosed is an audio signal adjusting apparatus for respectively adjusting a plurality of raw audio signals to produce a plurality of adjusted audio signals, comprising: audio signal adjusting means for respectively adjusting said raw audio signals to produce said adjusted audio signals, and to be operably connected with a plurality of loudspeakers for respectively producing a plurality of audio sounds in a specific sound space, said audio sounds being respectively indicative of said adjusted audio signals, and collectively originated from at least one imaginary sound source having a width, said imaginary sound source being imagined to produce said audio sounds at a location spaced apart from each of said loudspeakers; location control signal producing means for producing a location control signal indicative of said location of said imaginary sound source; controlling means for controlling said audio signal adjusting means to allow each of said raw audio signals to be adjusted by said audio signal adj