Abstract: Method of manufacture of probe carriers in which plural kinds of probes are arranged on substrates by ejecting plural kinds of probe solutions containing probe materials specifically associable to target substances from a liquid ejecting device onto the substrates, wherein the probe solutions are ejected from the liquid ejecting device onto the substrates while a substrate holding part whereupon the substrates are placed is moved relative to the liquid ejecting device and a manufacturing apparatus exclusively used for the method. The present invention enables stable manufacture of probe carriers without overflow of the probe solutions from reservoirs in which probe substances are held.

Abstract: Ambient humidity for a plurality of nozzles of a liquid ejection device for ejecting droplets of solutions containing probes to the surface of a carrier is controlled to 50% or more, preferably 60% or more. Part of solution supply passages to the plurality of nozzles are constructed from gas permeable membranes permitting gas-liquid separation under reduced pressure. These gas permeable membrane portions are gathered and altogether placed under reduced pressure to remove air bubbles from the respective solutions supplied to the plural nozzles and decrease the amount of a dissolved gas causing air bubble generation.

Abstract: A method for appropriately managing quality and distribution of probe carrier is provided. Probe carriers manufactured by a probe carrier manufacturing apparatus having ejecting portions for ejecting probe solutions, each containing a probe which can be specifically coupled with a target substance, for applying the probe solution on a carrier, and a plurality of probe tanks storing mutually different probe solutions for supplying ejecting portions. Each probe tanks are labeled with the bar-code. The labeled bar-code is read by the bar-code reader. On the basis of the read bar-code, the probe solution stored in the probe tank is identified. On the other hand, the probe tank is mounted on the ejecting portion.

Abstract: The present invention provides a process for detecting or quantifying a target nucleic acid in a sample, the process comprising the steps of associating a chemiluminescent compound, capable of being associated with a double-stranded nucleic acid, with a double-stranded nucleic acid including the target nucleic acid, and detecting or measuring chemiluminescence derived from the chemiluminescent compound associated with the double-stranded nucleic acid. According to the process, the target nucleic acid in the sample can be highly sensitively detected, or precisely quantified.

Abstract: A probe bound substrate allowing us to quickly detect or quantify a target substance or sequence a target nucleic acid at a lower cost is provided. Specifically, there is provided a probe bound substrate in which a probe capable of specifically attaching to a target substance is bound at the first site on its surface, characterized in that a marker is bound at the second site where the first site may be specified.

Abstract: A method for screening presence or absence of a variation in a region of a nucleic acid which comprises the steps of (a) preparing a sample containing a test nucleic acid corresponding to the region, (b) preparing a probe having a base sequence fully complementary to a normal sequence of the region, and a plurality of probes each having at least one base not complementary to the normal sequence, (c) fixing the probes in separate regions on a surface of a substrate to prepare a DNA array substrate, (d) reacting the test nucleic acid with the probes on the DNA array substrate, (e) measuring signals in each region where the signals are originated from respective hybrids formed between the test nucleic acid and one of the probes, and (f) calling variation in the test nucleic acid using a pattern of total signals of all regions.

Abstract: A surface plasmon resonance sensor apparatus includes a common substrate, a surface emitting laser, such as a VCSEL, arranged on the common substrate, a sensor array, such as CCD array, arranged on the common substrate, a light-transmitting medium provided above the common substrate, and a metal thin film formed on the light-transmitting medium to cause surface plasmon resonance due to light which is emitted from the surface emitting laser, transmitted through the light-transmitting medium and impinging on the metal thin film. The surface emitting laser, metal thin film and sensor array are positioned such that a change in an intensity of light reflected by the metal thin film caused by the surface plasmon resonance can be measured by the sensor array.

Abstract: A core material of an aluminum brazing sheet restricts Mg to less than 0.3 wt % and Fe to not more than 0.2 wt %, and contains more than 0.2 wt % and not more than 1.0 wt % of Cu, 0.3 to 1.3 wt % of Si, 0.3 to 1.5 wt % of Mn and the balance of Al and inevitable impurities. A brazing filler material is formed on one surface of the core material by Al—Si based aluminum alloy. Also, a cladding material is formed on the other surface of the core material, and contains less than 0.2 wt % of Si, 2.0 to 3.5 wt % of Mg, not less than 0.5 wt % and less than 2.0 wt % of Zn and the balance of Al and inevitable impurities. Further, the value (cladding material hardness)/(the core material hardness) that is a ratio of the hardness of the cladding material to the hardness of the core material is not more than 1.5.

Abstract: A method for dry detection/quantification of targeted nucleotide chains, comprising the steps of:

Abstract: A novel pyrylium compound is represented by the general formula (I): wherein X is oxygen or sulfur, Y− is a monovalent anion, n is an integer of 2 or 3, and M is hydrogen or an alkali metal. This pyrylium compound functions as a labeling agent by intermolecular bonding to nucleic acids, and as a fluorescence label having a chemical bond with the nucleic acids and an excitation wavelength in a visible light region.

Abstract: To provide an apparatus for painting figures which is improved in painting capability better than the conventional art even when a path to an external memory section is narrow. In order to simultaneously write previously generated painting information and read data required for generating painting information later in the painting coordinate generating section and the painting information generating section on the painting apparatus, while painting information is generated, first and second buffers are provided as a buffer section for storing painting information generated in the painting information generating section, and address information storing sections corresponding to the first and second buffers are provided as an address generating section for generating an address for storing painting information, which is accumulated in the buffer section, in an external memory section.

Abstract: A core material of an aluminum brazing sheet restricts Mg to less than 0.3 wt. % and Fe to not more than 0.2 wt. %, and contains more than 0.2 wt. % and not more than 1.0 wt. % of Cu, 0.3 to 1.3 wt. % of Si, 0.3 to 1.5 wt. % of Mn and the balance of Al and inevitable impurities. A brazing filler material is formed on one surface of the core material by Al-Si based aluminum alloy. Also, a cladding material is formed on the other surface of the core material, and contains less than 0.2 wt. % of Si, 2.0 to 3.5 wt. % of Mg, not less than 0.5 wt. % and less than 2.0 wt. % of Zn and the balance of Al and inevitable impurities. Further, the value (cladding material hardness)/(the core material hardness) that is a ratio of the hardness of the cladding material to the hardness of the core material is not more than 1.5.

Abstract: To provide a method of efficiently removing excitation light in a device for measuring fluorescence emitted from samples on a measuring surface of a substrate while illuminating the samples with excitation light.

Abstract: A surface plasmon resonance sensor apparatus includes a common substrate, a surface emitting laser, such as a VCSEL, arranged on the common substrate, a sensor array, such as CCD array, arranged on the common substrate, a light-transmitting medium provided above the common substrate, and a metal thin film formed on the light-transmitting medium to cause surface plasmon resonance due to light which is emitted from the surface emitting laser, transmitted through the light-transmitting medium and impinging on the metal thin film. The surface emitting laser, metal thin film and sensor array are positioned such that a change in an intensity of light reflected by the metal thin film caused by the surface plasmon resonance can be measured by the sensor array.

Abstract: In order to observe a front eye portion of an eye (E) to be examined, when a frame is moved to within a first region to approach the eye E to be examined, a stereo angle converting portion as means for shifting an optical path and a color temperature converting element (61) as optical converting means are removed from right and left optical axes (L1 and L2). On the other hand, in order to observe an eye fundus portion of the eye (E) to be examined, when the frame is moved to within a second region to leave the eye (E) to be examined, the stereo angle converting portion and the color temperature converting element (61) are disposed on the right and left optical axes (L1 and L2).

Abstract: The present invention provides a process for detecting or quantifying a target nucleic acid in a sample, the process comprising the steps of associating a chemiluminescent compound, capable of being associated with a double-stranded nucleic acid, with a double-stranded nucleic acid including the target nucleic acid, and detecting or measuring chemiluminescence derived from the chemiluminescent compound associated with the double-stranded nucleic acid. According to the process, the target nucleic acid in the sample can be highly sensitively detected, or precisely quantified.

Abstract: The present invention provides pharmaceutical compositions containing a pyrylium compound, a thiopyrylium compound, a selenopyrylium compound or a telluropyrylium compound or a salt of any of the aforesaid compounds as active ingredient. The compounds are selectively absorbed by cancer cells or similar growths in the human or animal body and can be used to bring about distruction of the unwanted growth an irradiation with light of wavelength 600 nm to 1000 nm. The invention also provides a method for the treatment of the human or animal body which comprises administering the compound to a human or animal and irradiating a locus in said animal where the compound is absorbed in order to kill cells at that locus. It further comprises the use of the aforesaid compound for the making of a medicament for use in the treatment of cancer in humans and animals.

Abstract: A bus for data transmission, bus switches for slicing the bus, and four arithmetic blocks are provided to perform a series of fixed-point arithmetic operations. Each of the four arithmetic blocks has a plurality of digit-serial arithmetic units, namely a multiplier, an adder/subtracter, and a shifter. Each of the digit-serial arithmetic units has the functions of receiving a plurality of input digits representative of an input operand and a digit position indicator of each of the input digits and providing a plurality of result digits representative of an arithmetic result of the input operand and a digit position indicator of each of the result digits to any other one of the plurality of digit-serial arithmetic units. Particularly, the digit-serial adder/subtracter contains therein a selector for input switching so that the digit-serial adder/subtracter can perform butterfly arithmetic.

Abstract: An apparatus for receiving broadcasting signals, which includes a tuner for receiving a digital audio broadcasting signal, a channel decoder for obtaining audio information data, service information data and control information based on the digital audio broadcasting signal received by the tuner, a source decoder for causing the audio information data to be subjected to a decoding processing to produce a digital audio signal, a digital audio signal transmission processor for obtaining a first digital transmission signal based on the digital audio signal, a service data producing portion for obtaining service data based on the control information and the service information data, a service data transmission processor for obtaining a second digital transmission signal based on the service data, a switch for deriving selectively the first and second digital transmission signals, and a digital output transmitter for forwarding a digital transmission output obtained based on one of the first and second digital tra

Abstract: A method for detecting a target substance in a sample comprises the steps of providing at least two reagents which can form a reaction system for causing changes as the result of an interaction therebetween the interaction being caused only when the target substance is present in the sample, reacting the reagents with the target substance, and measuring the resulting changes based on the interaction, wherein at least one of the reagents forming the reaction system is selected from specific pyrylium compounds.