Abstract: The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring the glucose derivative which has flowed into the cells, wherein the test substance is determined to be a diabetes treating agent if the test substance accelerates uptake of the glucose derivative in the cells. Therefore, the described pharmaceutical composition, including a triazin-based compound as an active ingredient, can be useful for application in preventing or treating diabetes.

Abstract: A spool type control valve, comprising: a valve block having a cylinder bore with drilled holes on the cylinder bore internal wall; a valve spool inserted in the cylinder bore; wherein the valve spool having separation sleeves each being spaced apart on the valve spool; wherein an all-metal-seal ring is assembled and fitted on each of the separation sleeves; and wherein each of the all-metal-seal rings is constructed with three different functioning ring layers: a cylinder seal layer, an absorption layer, and a shaft seal layer; wherein the cylinder seal layer seals the cylinder bore internal wall and does come into contact with the valve spool surface; wherein the absorption layer absorbs any dimensional variations during dynamic movement of the valve spool; and shaft seal layer seals the valve spool and does not come into contact with the cylinder bore internal wall.

Abstract: An injection fuel pump, comprising: a pump body; a drive shaft assembled into the pump body; a piston-drive cam assembled on to the drive shaft; and one or more cylinder heads, each comprising: a pump piston inserted in a cylinder bore, wherein the pump piston is fitted with one or more all-metal-seal rings; wherein the pump piston that is fitted with one or more all-metal-seal rings having a cross-sectional area that is the same as the cylinder bore cross-sectional area, as such creating zero internal leakage. In one embodiment, the all-metal-seal rings are coiled felt seals.

Abstract: Provided are spectacle frames and a manufacturing method thereof, in which a front of the spectacle frames is formed by processing a celluloid plate of plastic, and temples are mounted on the front of the spectacle frames, thereby manufacturing the spectacle frames using the celluloid plate. The present invention does not require injection molding and an injection mold, and by processing both a hinge part and the front of the spectacle frames, the spectacle frames that can be applied to various wearers' face sizes can be manufactured with only the front of the frames having a single size. Also, by merely changing a design, various designs of the spectacle frames can be realized with only the front of the frames having a single size.

Abstract: A data processing method of a memory controller includes receiving first partial data of a last sector data among a plurality of sector data to be stored in an n-th page of a non-volatile memory in a program operation; padding the first partial data with first dummy data and generating a first error correction code (ECC) parity in the program operation; and transferring the first partial data and the first ECC parity to the non-volatile memory in the program operation, while refraining from transferring the first dummy data to the non-volatile memory. Related devices and systems are also described.

Abstract: Pistons and piston rods of hydraulic cylinders are fitted with coiled felt seal (CFS) in place of rubber O-rings for the sealing of the cylinders. The resulting piston-cylinder mechanical device has a simpler structure, lesser number of components without the multiple rubber O-rings, improved durability and higher performance with extreme temperature tolerance, enhanced internal pressure capacity, reduced power loss due to reduced piston-cylinder friction, and significantly reduced leakage.

Abstract: Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided.

Abstract: An axial piston pump, comprising a cylinder block having one or more cylinder bores; and one or more piston assemblies; wherein number of piston assemblies matches number of cylinder bores; wherein each of the piston assemblies having a piston being disposed reciprocating in each of the cylinder bores; and wherein each piston being fitted with a metallic sealing ring, which is a coiled felt seal (CFS), for reducing leakage and keeping concentric of the piston within its corresponding cylinder bore.

Abstract: A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: wherein W is selected from the group consisting of an optionally substituted aryl group and an optionally substituted heteroaryl group; each Y independently is NR1R2, wherein R1 and R2 are independently selected from the group consisting of H and C1-C6 alkyl, or R1 and R2 combine to form together with the nitrogen to which they are attached a heterocyclic group with 4 to 5 carbon atoms, is used to denote a single or a double bond, and Z is NH, NH2, NH—(C?O)—(CH2)n—SH, wherein n=1 to 10, or or a tautomer or stereoisomer thereof, or a salt thereof. A method and device for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) is also provided.

Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.

Abstract: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.

Abstract: The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods include providing a sample potentially containing such cells and providing a rosamine derivative compound of the formula (I): where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells based on fluorescent signals emitted by the sample following said contacting.

Abstract: The present invention provides a method of preparing an alkylamine derivates which hardly generates impurities and enables mass production with high purity.

Abstract: Technologies are generally described for controlling remote display. In some examples, a method for controlling a remote display device using a handheld computing device includes receiving, by a handheld computing device, one or more data from one or more remote display devices over a wireless communication network, selecting a remote display device based on the received data and sending a control signal to the selected remote display device.

Abstract: The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.

Abstract: The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPAR?2, LPL and ?P2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual.

Abstract: This invention relates to a screening method for an inhibitor to cancer cell invasion, comprising the steps of: (a) co-culturing cancer cells and a carcinoma-associated fibroblasts (CAFs) in a multi-chamber containing a upper-chamber, a lower-chamber and a porous filter separating the upper-chamber from the lower-chamber; in which each cancer cells and CAFs is inoculated into the upper-chamber and the lower-chamber of the multi-chamber, and then a candidate is added to the upper-chamber; and (b) measuring the number of cancer cells passing the porous filter. According to the screening system and screening method using the same, the inhibitor to cancer cell invasion is able to be screened in a high-throughput manner.

Abstract: Disclosed are powders or extracts of plant leaves with anti-obesity effects and anti-obesity foods comprising them, and more particularly, anti-obesity food compositions comprising powders or extracts of one or more selected from group consisting of persimmon (Diospyros KakI Thunb.) leaves, buckwheat (Fagopyrum esculentum) leaves, Chinese matrimony vine (Lycium chinense) leaves, endive (Cichorium endivia) leaves, and ginseng (Panax ginseng). Also disclosed are compositions comprising plant extracts or powders to reduce the weight of animals or humans, and more particularly, boiling water extracts of persimmon leaves, buckwheat leaves and Chinese matrimony vine leaves and persimmon leaf powder, buckwheat leaf powder and Chinese matrimony vine leaf powder were prepared and administered to animals or humans to confirm the effects of reduction of their weight and then health foods comprising the extracts or powders are produced.

Abstract: A memory system is provided. The memory system includes a nonvolatile memory and a controller. The nonvolatile memory includes a memory cell array and a read/write circuit configured to perform a read/write operation in the memory cell array during a read operation. The controller is configured to receive the read data from the nonvolatile memory, perform an error detection and correction operation on the read data. Upon detecting an error in a received portion of the read data, the controller is further configured to halt further transmission of the read data from the nonvolatile memory, perform the error detection and correction operation on the received portion of the read data to correct the detected error. After correcting the detected error in the received portion of the read data, the controller is configured to resume transmission of the read data from the nonvolatile memory.

Abstract: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.