Publication number: 20070244116
Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Type:
Application
Filed:
May 24, 2007
Publication date:
October 18, 2007
Applicant:
EXELIXIS, INC.
Inventors:
LYNNE BANNEN, Diva Chan, Jeff Chen, Lisa Dalrymple, Timothy Forsyth, Tai Huynh, Vasu Jammalamadaka, Richard Khoury, James Leahy, Morrison Mac, Grace Mann, Larry Mann, John Nuss, Jason Parks, Craig Takeuchi, Yong Wang, Wei Xu