Patents by Inventor Tai-Tung Yip
Tai-Tung Yip has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8748193Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.Type: GrantFiled: February 17, 2009Date of Patent: June 10, 2014Assignee: Baylor College of MedicineInventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 8470610Abstract: Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: August 17, 2011Date of Patent: June 25, 2013Assignee: Bio-Rad Laboratories, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Publication number: 20120220491Abstract: Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: ApplicationFiled: August 17, 2011Publication date: August 30, 2012Applicant: Bio-Rad Laboratories, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 8206934Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: GrantFiled: September 11, 2009Date of Patent: June 26, 2012Assignee: Vermillion, Inc.Inventors: Eric Thomas Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
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Patent number: 8173433Abstract: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.Type: GrantFiled: April 22, 2005Date of Patent: May 8, 2012Assignee: Vermillion, Inc.Inventors: Judah M. Folkman, Giannoula Klement, Tai-Tung Yip, William E. Rich, Vladimir N. Podust
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Publication number: 20110313681Abstract: This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.Type: ApplicationFiled: August 25, 2011Publication date: December 22, 2011Applicants: Vermillion, Inc., Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric T. Fung, John P. Cooke, Xiao-Ying Meng, Tai-Tung Yip, Fujan Zhang
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Patent number: 8021894Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: August 14, 2009Date of Patent: September 20, 2011Assignee: Bio-Rad Laboratories, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 8014952Abstract: Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer.Type: GrantFiled: December 16, 2003Date of Patent: September 6, 2011Assignees: Queen Elizabeth Hospital, Vermillion, Inc.Inventors: Timothy Tak Chun Yip, Chi Shing Cho, Siu Kie Au, Tai-Tung Yip, Christine Yip, Victor Yip
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Patent number: 8008020Abstract: This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.Type: GrantFiled: May 26, 2005Date of Patent: August 30, 2011Assignees: Vermillion, Inc., Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric T. Fung, John P. Cooke, Xiao-Ying Meng, Tai-Tung Yip, Fujun Zhang
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Publication number: 20100086949Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: ApplicationFiled: August 14, 2009Publication date: April 8, 2010Applicant: Bio-Rad Laboratories, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Publication number: 20100047847Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: ApplicationFiled: September 11, 2009Publication date: February 25, 2010Applicants: Vermillion, Inc., Sahlgrenska Academy at Goeteborg UniversityInventors: Eric T. Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
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Publication number: 20090256069Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.Type: ApplicationFiled: February 17, 2009Publication date: October 15, 2009Applicant: Baylor College of MedicineInventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 7575935Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: September 25, 2006Date of Patent: August 18, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Publication number: 20090181414Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: ApplicationFiled: September 25, 2006Publication date: July 16, 2009Applicant: Ciphergen Biosystems, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 7491549Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.Type: GrantFiled: August 10, 2006Date of Patent: February 17, 2009Assignee: Baylor College of MedicineInventors: T. William Hutchens, Tai-Tung Yip
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Publication number: 20090042229Abstract: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.Type: ApplicationFiled: April 22, 2005Publication date: February 12, 2009Applicants: CIPHERGEN BIOSYSTEMS, INC., CHILDRENS MEDICAL CENTER CORPORATIONInventors: Judah M. Folkman, Giannoula Klement, Tai-Tung Yip, William E. Rich, Vladimir N. Podust
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Patent number: 7479631Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: GrantFiled: March 2, 2007Date of Patent: January 20, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Patent number: 7449150Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.Type: GrantFiled: February 3, 2006Date of Patent: November 11, 2008Assignee: Baylor College of MedicineInventors: T William Hutchens, Tai-Tung Yip
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Publication number: 20080274481Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: ApplicationFiled: March 27, 2008Publication date: November 6, 2008Applicants: Vermillion, Inc., Sahlgrenska Academy at Goeteborg UniversityInventors: Eric T. Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
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Patent number: 7413909Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.Type: GrantFiled: June 30, 2004Date of Patent: August 19, 2008Assignee: Baylor College of MedicineInventors: T. William Hutchens, Tai-Tung Yip