Abstract: An object of the present invention is to provide a 2,6-dioxo-3,6-dihydropyrimidine compound that has excellent bactericidal and antimicrobial activity, has excellent safety, and can be industrially favorably synthesized, and an agricultural and horticultural fungicide, a nematicide, and an antifungal agent for use in medicine/animals that contain the compound as an active ingredient.

Abstract: In particle beam irradiation equipment, a control unit causes a storage unit to store, as position information of reference positions, position information of electromagnets that is acquired at the time of their first alignment, by cameras, and then acquires displacement amounts, based on the position information of the reference positions stored in the storage unit and from position information of the electromagnets acquired at the time of their realignment, by the cameras.

Abstract: A treatment planning apparatus includes an overall data management unit for storing a target irradiation dose distribution to be formed in an irradiation object, a broad irradiation parameter calculation unit and a scanning irradiation parameter calculation unit for cooperatively calculating and determining operational parameters for devices, such as an accelerator and an irradiation nozzle, to operate during a broad irradiation and an scanning irradiation, respectively, so that the sum of irradiation doses imparted by both broad irradiation and scanning irradiation forms the target irradiation dose distribution.

Abstract: A scanning candidate route extracting unit which extracts plural candidates of scanning routes in which each of the scanning routes connects all spot positions in one layer is provided, in an evaluation function using necessary scanning time Tk and weight coefficient wk for a kth partial route among partial routes which are routes between the spot positions which are adjacent on one of the plural candidates of scanning routes, and number n of spot in the layer, wk with respect to a partial route which passes through affected tissue is set to be 1, wk with respect to a partial route which passes through normal tissue is set to be bigger than 1, and wk with respect to a partial route which passes through an important internal organ is set to be bigger than wk with respect to a partial route which passes through normal tissue.

Abstract: An irradiation apparatus radiates a particle beam after forming the beam for plural layers. A dose monitor measures a dose in real time. A dose evaluation unit evaluates an irradiation dose for each layer on the basis of a value measured by the dose monitor and a dose calibration factor set for each layer. An irradiation control section performs radiation control for each layer on the basis of an evaluation result of the dose evaluation unit. An interpolation value generation unit uses actual-measurement dose-calibration factors obtained by radiating a particle beam to a simulated phantom provided with a calibration dosimeter, to generate an interpolation estimation value of the dose calibration factor. For each layer subject to the interpolation value, and based on an irradiation condition of that layer, the interpolation value generation unit performs weighting on each of the actual-measurement dose-calibration factors.

Abstract: When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam.

Abstract: A method of assisting designing of a particle beam therapy facility includes: a local-concave region calculation step of calculating a volume of a local concave region which is a concave region between two treatment-room models arranged most adjacent to each other, among multiple treatment-room models arranged in a model space corresponding to a target space for arrangement, or a projected area of the local concave region; a concave-region calculation-result display step of displaying the volume or the projected area of the local concave region calculated in the local-concave region calculation step, on a display device of a design assisting device; and a treatment-room model displacement step of displacing the treatment-room model in the model space in response to a displacement instruction for that treatment-room model, when no operation-termination instruction is issued after the concave-region calculation-result display step; wherein the above three steps are repeated until an operation-termination instru

Abstract: In particle beam irradiation equipment, a control unit causes a storage unit to store, as position information of reference positions, position information of electromagnets that is acquired at the time of their first alignment, by cameras, and then acquires displacement amounts, based on the position information of the reference positions stored in the storage unit and from position information of the electromagnets acquired at the time of their realignment, by the cameras.

Abstract: A control device (control unit) to be used for controlling a scanning electromagnet that is used for scanning irradiation, which includes: a command-value processing line (a memory, an arithmetic circuit, an interface) that generates a command value for driving the scanning electromagnet on the basis of a treatment plan, and outputs the generated command value in synchronization with an accelerator; and a comparator unit that detects an error in the processing line; wherein a circuit (for example, the arithmetic circuit) that constitutes at least a part of the processing line is made redundant, and the comparator unit detects occurrence of the error in the processing line when outputs from the circuit made redundant are unmatched to each other.

Abstract: In the particle beam therapy system, a beam transport system includes a beam-path changer for changing a beam path so as to transport a charged particle beam to any one of the plurality of particle beam irradiation apparatuses; and a treatment management device includes a beam-path controller that generates an emitter control signal for controlling an emitter of an accelerator and a beam-path changer control signal for controlling the beam-path changer so that, with respect to the plurality of particle beam irradiation apparatuses in which treatment is performed at the same treatment period of time, the charged particle beam is transported to each one of the plurality of particle beam irradiation apparatuses for each time period allocated thereto.

Abstract: A scanning candidate route extracting unit which extracts plural candidates of scanning routes in which each of the scanning routes connects all spot positions in one layer is provided, in an evaluation function using necessary scanning time Tk and weight coefficient wk for a kth partial route among partial routes which are routes between the spot positions which are adjacent on one of the plural candidates of scanning routes, and number n of spot in the layer, wk with respect to a partial route which passes through affected tissue is set to be 1, wk with respect to a partial route which passes through normal tissue is set to be bigger than 1, and wk with respect to a partial route which passes through an important internal organ is set to be bigger than wk with respect to a partial route which passes through normal tissue.

Abstract: In the particle beam therapy system, a beam transport system includes a beam-path changer for changing a beam path so as to transport a charged particle beam to any one of the plurality of particle beam irradiation apparatuses; and a treatment management device includes a beam-path controller that generates an emitter control signal for controlling an emitter of an accelerator and a beam-path changer control signal for controlling the beam-path changer so that, with respect to the plurality of particle beam irradiation apparatuses in which treatment is performed at the same treatment period of time, the charged particle beam is transported to each one of the plurality of particle beam irradiation apparatuses for each time period allocated thereto.

Abstract: A scanning candidate route extracting unit which extracts plural candidates of scanning routes in which each of the scanning routes connects all spot positions in one layer is provided, in an evaluation function using necessary scanning time Tk and weight coefficient wk for a kth partial route among partial routes which are routes between the spot positons which are adjacent on one of the plural candidates of scanning routes, and number n of spot in the layer, wk with respect to a partial route which passes through affected tissue is set to be 1, wk with respect to a partial route which passes through normal tissue is set to be bigger than 1, and wk with respect to a partial route which passes through an important internal organ is set to be bigger than wk with respect to a partial route which passes through normal tissue.

Abstract: An irradiation apparatus radiates a particle beam after forming the beam for plural layers. A dose monitor measures a dose in real time. A dose evaluation unit evaluates an irradiation dose for each layer on the basis of a value measured by the dose monitor and a dose calibration factor set for each layer. An irradiation control section performs radiation control for each layer on the basis of an evaluation result of the dose evaluation unit. An interpolation value generation unit uses actual-measurement dose-calibration factors obtained by radiating a particle beam to a simulated phantom provided with a calibration dosimeter, to generate an interpolation estimation value of the dose calibration factor. For each layer subject to the interpolation value, and based on an irradiation condition of that layer, the interpolation value generation unit performs weighting on each of the actual-measurement dose-calibration factors.

Abstract: There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis.

Abstract: A scanning candidate route extracting unit which extracts plural candidates of scanning routes in which each of the scanning routes connects all spot positions in one layer is provided, in an evaluation function using necessary scanning time Tk and weight coefficient wk for a kth partial route among partial routes which are routes between the spot positons which are adjacent on one of the plural candidates of scanning routes, and number n of spot in the layer, wk with respect to a partial route which passes through affected tissue is set to be 1, wk with respect to a partial route which passes through normal tissue is set to be bigger than 1, and wk with respect to a partial route which passes through an important internal organ is set to be bigger than wk with respect to a partial route which passes through normal tissue.

Abstract: When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam.

Abstract: The particle beam irradiation apparatus comprises: a position monitor that detects a passing position of a charged particle beam; and an irradiation control apparatus that calculates a distance from a predetermined reference point to the position monitor, calculates a beam irradiation position on an irradiation subject, and controls irradiation of the beam; wherein the irradiation control apparatus includes a position calculation apparatus that calculates the beam irradiation position, based on a beam position detected by the position monitor, a scanning starting point distance information on a distance from a irradiation plane of the irradiation subject to a scanning starting point, of the beam, in a scanning electromagnet, and a position monitor distance information on a distance, from the irradiation plane to the position monitor, that is calculated based on the calculated distance.

Abstract: When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam.

Abstract: A control device (control unit) to be used for controlling a scanning electromagnet that is used for scanning irradiation, which includes: a command-value processing line (a memory, an arithmetic circuit, an interface) that generates a command value for driving the scanning electromagnet on the basis of a treatment plan, and outputs the generated command value in synchronization with an accelerator; and a comparator unit that detects an error in the processing line; wherein a circuit (for example, the arithmetic circuit) that constitutes at least a part of the processing line is made redundant, and the comparator unit detects occurrence of the error in the processing line when outputs from the circuit made redundant are unmatched to each other.