Patents by Inventor Takafumi Tsuboi
Takafumi Tsuboi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11835520Abstract: A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.Type: GrantFiled: December 21, 2017Date of Patent: December 5, 2023Assignee: The Walter and Eliza Hall Institute of Medical ResearchInventors: Ivo Mueller, Takafumi Tsuboi, Michael White, Rhea Longley
-
Publication number: 20230322910Abstract: The present disclosure includes a monoclonal antibody or antibody fragment that binds to an epitope consisting of 5 to 20 consecutive amino acids in the amino acid sequence of SEQ ID NO: 1, and a method of detecting or quantifying an Ripr-derived malaria vaccine antigen comprising contacting a sample with the monoclonal antibody or antibody fragment.Type: ApplicationFiled: August 25, 2021Publication date: October 12, 2023Inventors: Takafumi Tsuboi, Eizo Takashima, Hikaru Nagaoka, Akihisa Fukushima
-
Publication number: 20230109998Abstract: Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(methyl)amino]ethyl}-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaeneamide, or a pharmaceutically acceptable salt thereof, as a vaccine adjuvant with enhanced specific immune response against antigens and good preservation stability and a malaria vaccine with non-glycosylation, homogeneity, and biological activity allow for the provision of malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action.Type: ApplicationFiled: November 6, 2020Publication date: April 13, 2023Inventors: C. Richter King, Yimin Wu, Jordan Lee Plieskatt, Shwu-Maan Lee, Chia-Kuel Wu, Takafumi Tsuboi, Akihisa Fukushima
-
Patent number: 11273212Abstract: The present invention relates to a polypeptide consisting of an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, (b) an amino acid sequence that differs from the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8 by substitution, deletion, addition, or insertion of 1 to 10, preferably 1-5, more preferably 1, 2 or 3 amino acids, and (c) an amino acid sequence that has at least 95%, preferably 97%, more preferably 99% sequence identity with the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, and a malaria vaccine comprising the polypeptide, for example.Type: GrantFiled: November 10, 2017Date of Patent: March 15, 2022Assignees: Sumitomo Dainippon Pharma Co., Ltd., National University Corporation Ehime UniversityInventors: Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima, Hikaru Nagaoka
-
Publication number: 20210132063Abstract: A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.Type: ApplicationFiled: December 21, 2017Publication date: May 6, 2021Applicant: The Walter and Eliza Hall Institute of Medical ResearchInventors: Ivo Mueller, Takafumi Tsuboi, Michael White, Rhea Longley
-
Publication number: 20190343943Abstract: The present invention relates to a polypeptide consisting of an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, (b) an amino acid sequence that differs from the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8 by substitution, deletion, addition, or insertion of 1 to 10, preferably 1-5, more preferably 1, 2 or 3 amino acids, and (c) an amino acid sequence that has at least 95%, preferably 97%, more preferably 99% sequence identity with the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, and a malaria vaccine comprising the polypeptide, for example.Type: ApplicationFiled: November 10, 2017Publication date: November 14, 2019Inventors: Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima, Hikaru Nagaoka
-
Patent number: 9222139Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: December 16, 2014Date of Patent: December 29, 2015Assignees: EHIME UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Patent number: 9222140Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: December 16, 2014Date of Patent: December 29, 2015Assignees: EHIME UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Patent number: 9200332Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: July 29, 2015Date of Patent: December 1, 2015Assignees: EHIME UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Publication number: 20150322534Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: July 29, 2015Publication date: November 12, 2015Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EHIME UNIVERSITYInventors: Takafumi TSUBOI, Eun-Taek HAN
-
Publication number: 20150184252Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: December 16, 2014Publication date: July 2, 2015Applicants: EHIME UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Takafumi TSUBOI, Eun-Taek HAN
-
Publication number: 20150176083Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: December 16, 2014Publication date: June 25, 2015Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EHIME UNIVERSITYInventors: Takafumi TSUBOI, Eun-Taek HAN
-
Patent number: 8936920Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: June 13, 2012Date of Patent: January 20, 2015Assignees: Ehime University, Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Patent number: 8580274Abstract: An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the immunogenicity of the vaccine or capable of enhancing the immunostimulating effect of the adjuvant as well as a vaccine or adjuvant utilizing the same. Said drug delivery vehicle contains a multimeric protein having a coiled coil structure and a ligand molecule to a receptor of an immune cell.Type: GrantFiled: February 10, 2010Date of Patent: November 12, 2013Assignee: University of the RyukyusInventors: Takeshi Arakawa, Takeshi Miyata, Goro Matsuzaki, Takafumi Tsuboi
-
Publication number: 20130149317Abstract: The present invention relates to a malaria vaccine comprising: (a) a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3; (b) a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3, wherein one or more amino acids are deleted, substituted and/or added and having effect for preventing falciparum malaria; or (c) a polypeptide consisting of an amino acid sequence having 70% or more identity with an amino acid sequence of SEQ ID NO: 1, 2, or 3 and having effect for preventing falciparum malaria.Type: ApplicationFiled: July 4, 2011Publication date: June 13, 2013Applicant: CELLFREE SCIENCES CO., LTD.Inventors: Takafumi Tsuboi, Motomi Torii, Tatsuya Sawasaki, Yaeta Endo
-
Publication number: 20130017221Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: June 13, 2012Publication date: January 17, 2013Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EHIME UNIVERSITYInventors: Takafumi TSUBOI, Eun-Taek HAN
-
Patent number: 8309702Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: May 27, 2008Date of Patent: November 13, 2012Assignees: Ehime University, Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Publication number: 20120100165Abstract: An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the immunogenicity of the vaccine or capable of enhancing the immunostimulating effect of the adjuvant as well as a vaccine or adjuvant utilizing the same. Said drug delivery vehicle contains a multimeric protein having a coiled coil structure and a ligand molecule to a receptor of an immune cell.Type: ApplicationFiled: February 10, 2010Publication date: April 26, 2012Applicant: University of the RyukyusInventors: Takeshi Arakawa, Takeshi Miyata, Goro Matsuzaki, Takafumi Tsuboi
-
Publication number: 20100183679Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: May 25, 2008Publication date: July 22, 2010Inventors: Takafumi Tsuboi, Eun-Taek Han
-
Publication number: 20080274132Abstract: The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.Type: ApplicationFiled: July 2, 2008Publication date: November 6, 2008Applicant: The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human ServicesInventors: David C. KASLOW, Takafumi Tsuboi, Motomi Torii