Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: A fuel injection control device includes a throttle opening read timing setter that sets the timing at which a throttle opening is read. The setter is triggered to detect the throttle opening used for calculation of a basic injection amount by the start of calculation timing of the basic injection amount (FICAL) if the FICAL is at the position corresponding to a toothless part of a crank pulsar rotor. The setter detects the throttle opening based on crank pulse interrupt according to a crank pulse if the FICAL is at a position other than the position corresponding to the toothless part.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: A fuel injection amount calculation method calculates a fuel injection amount to an internal combustion engine of a vehicle. The method can include calculating a relative intake pressure which is a difference between an intake pressure peak of intake air upon intake starting of a cylinder of the internal combustion engine and an intake pressure bottom of the intake air upon intake ending. The method can also include calculating the fuel injection amount based on the relative intake pressure.

Abstract: In a vehicle outside rearview mirror device including a mirror housing capable of tilting with respect to a vehicle body, the vehicle outside rearview mirror device includes a base fixed to the vehicle body; a shaft fixed to the base; and the mirror housing mounted to the shaft so as to be capable of tilting, wherein a wall that reduces a flow rate of a wind passing through a gap between the base and the mirror housing is provided to the shaft.

Abstract: A method for positioning a work, which is adapted for a knock hole of a small diameter and which can absorb a pitch error between a main positioning hole and an auxiliary positioning hole of the work is disclosed. An insert shaft of a main positioning device is inserted into the main positioning hole. An auxiliary positioning device includes a base lower block having a parallel slide holding surface, a sliding flange having a sliding surface, and an insert shaft disposed above the sliding flange. The sliding flange of the auxiliary positioning device is guided and moved by the slide holding surface, and is inserted, while absorbing the pitch error, into the auxiliary positioning hole, thereby to position the work.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: A magnesium alloy sheet having high impact resistance at low temperature, a magnesium alloy structural member using this sheet, and a method for producing a magnesium alloy sheet are provided. The magnesium alloy sheet is composed of a magnesium alloy containing Al and Mn. When a region from a surface of the alloy sheet to 30% of the thickness of the alloy sheet in a thickness direction of the magnesium alloy sheet is defined as a surface region and when a 50 ?m2 sub-region is arbitrarily selected from this surface region, the number of grains that are crystallized phases containing both Al and Mn is 15 or less. The maximum diameter of each of the crystallized phases is 0.1 to 1 ?m and the mass ratio Al/Mn of Al to Mn is 2 to 5. This magnesium alloy sheet has high impact resistance since it contains crystallized phases that are small in size and in amount contained and cause breaking and the like, and exhibits good mechanical properties even in a low-temperature environment.

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.

Abstract: To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl, group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.

Abstract: Intended is to provide a method for positioning a work (15), which is adapted for a knock hole of a small diameter and which can absorb a pitch error between a main positioning hole (16) and an auxiliary positioning hole (17) of the work (15). An insert shaft (21) of main positioning means 820) is inserted into the main positioning hole (16). Auxiliary positioning means (30) includes a base lower block (36) having a parallel slide holding surface (36e), a sliding flange (34b) having a sliding surface (34c), and an insert shaft (31) disposed above the sliding flange (34b). The sliding flange (34b) of the auxiliary positioning means (30) is guided and moved by the slide holding surface (36e), and is inserted, while absorbing the pitch error, into the auxiliary positioning hole (17), thereby to position the work (15).

Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl, group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.

Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.

Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.