Patents by Inventor Takahiro Kitamura
Takahiro Kitamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20080119474Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: January 14, 2008Publication date: May 22, 2008Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Publication number: 20080095916Abstract: A method of processing wheat flour that without detriment to secondary processability, improves the flavor and palate feelings thereof, processed wheat flour obtained by the processing method; and fool utilizing the processed wheat flour. The method is characterized in that 10 to 55 pts.wt. of ethyl alcohol is homogeneously dispersed in 100 pts.wt. of wheat flour under such conditions that the total water content is ?20 wt. %, followed by evaporation of ethyl alcohol therefrom at ?50° C.Type: ApplicationFiled: May 6, 2005Publication date: April 24, 2008Applicant: Lotte Co., Ltd.Inventors: Masanori Ito, Kazuhiro Sano, Takahiro Kitamura, Koji Murakami, Toshiyuki Koyama
-
Publication number: 20070208025Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: April 30, 2007Publication date: September 6, 2007Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Patent number: 7211577Abstract: A phenylpyridazine derivative represented by the formula (1): Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. The present invention provides water-soluble phenylpyridazine derivatives and medicines containing them, which have excellent inhibitory activity against interleukin-? production, high water solubility and high oral absorbability.Type: GrantFiled: March 16, 2004Date of Patent: May 1, 2007Assignee: Kowa Co., Ltd.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Publication number: 20070049595Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: November 1, 2006Publication date: March 1, 2007Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Patent number: 7109242Abstract: A compound represented by the following general formula (1), a salt thereof, or an ester thereof: wherein m represents an integer of 0 to 4, n represents an integer of 5 to 9, and R represents hydrogen atom or a protective group of hydroxyl group, which has reducing actions of blood glucose, plasma insulin, and triglyceride, and is useful for preventive and/or therapeutic treatment of diabetes, complications of diabetes, hyperlipemia and others.Type: GrantFiled: May 21, 2004Date of Patent: September 19, 2006Assignee: Kowa Company, Ltd.Inventors: Keisuke Inoue, Tsutomu Toma, Takahiro Kitamura, Yukiyoshi Yamazaki, Tetsuya Ishikawa
-
Patent number: 7087606Abstract: Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R2 and R3 may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1? production, high water solubility and good oral absorbability.Type: GrantFiled: October 12, 2004Date of Patent: August 8, 2006Assignee: Kowa Co., Ltd.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Publication number: 20060160804Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: March 22, 2006Publication date: July 20, 2006Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Publication number: 20060142292Abstract: A phenylpyridazine derivative represented by the formula (1): Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. The present invention provides water-soluble phenylpyridazine derivatives and medicines containing them, which have excellent inhibitory activity against interleukin-? production, high water solubility and high oral absorbability.Type: ApplicationFiled: March 16, 2004Publication date: June 29, 2006Applicant: Kowa Co., Ltd.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Publication number: 20050267113Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: August 15, 2005Publication date: December 1, 2005Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Publication number: 20050131001Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: ApplicationFiled: November 9, 2004Publication date: June 16, 2005Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Kirata
-
Publication number: 20050131002Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: ApplicationFiled: November 9, 2004Publication date: June 16, 2005Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
-
Publication number: 20050085480Abstract: Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R2 and R3 may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1? production, high water solubility and good oral absorbability.Type: ApplicationFiled: October 12, 2004Publication date: April 21, 2005Applicant: KOWA CO., LTD.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Publication number: 20050065155Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.Type: ApplicationFiled: November 12, 2004Publication date: March 24, 2005Applicant: KOWA CO., LTD.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Patent number: 6869954Abstract: Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R2 and R3 may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1? production, high water solubility and good oral absorbability.Type: GrantFiled: September 25, 2002Date of Patent: March 22, 2005Assignee: Kowa Co., Ltd.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Patent number: 6861428Abstract: Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R2 and R3 may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represents a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to pharmaceutical compositions containing them. These compounds have inhibitory activity against IL-1? production, high water solubility and good oral absorbability.Type: GrantFiled: March 26, 2003Date of Patent: March 1, 2005Assignee: Kowa Co., Ltd.Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
-
Patent number: 6849647Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: GrantFiled: September 20, 2000Date of Patent: February 1, 2005Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
-
Publication number: 20050009909Abstract: A compound represented by the following general formula (1), a salt thereof, or an ester thereof: wherein m represents an integer of 0 to 4, n represents an integer of 5 to 9, and R represents hydrogen atom or a protective group of hydroxyl group, which has reducing actions of blood glucose, plasma insulin, and triglyceride, and is useful for preventive and/or therapeutic treatment of diabetes, complications of diabetes, hyperlipemia and others.Type: ApplicationFiled: May 21, 2004Publication date: January 13, 2005Applicant: KOWA Company, Ltd.Inventors: Keisuke Inoue, Tsutomu Toma, Takahiro Kitamura, Yukiyoshi Yamazaki, Tetsuya Ishikawa
-
Publication number: 20040147516Abstract: This invention relates to pyridazine derivatives represented by the formula (1): 1Type: ApplicationFiled: January 15, 2004Publication date: July 29, 2004Applicant: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
-
Patent number: 6680316Abstract: Objects of the invention are to provide compounds having excellent activity against interleukin-1&bgr; production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): wherein Ar1 represents a substituted or unsubstituted aromatic group, Ar2 represents a phenyl group having a substituent at least at the 4-position thereof, R1 represents a linear or branched alkyl group, an alkyl group having a cyclic structure, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenyl(lower alkyl) group, and R2 represents a cyano group, a carboxyl group, a (lower alkoxy)carbonyl group, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted carbamoyl group, or salts thereof; and medicines comprising them as effective ingredients.Type: GrantFiled: August 20, 2001Date of Patent: January 20, 2004Assignee: Kowa Co., Ltd.Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Hideo Yoshizaki, Tomoyuki Koshi, Takahiro Kitamura, Takayuki Matsuda, Kyoko Yasuoka, Tomoko Furuyama