Patents by Inventor Takahiro Ochiya

Takahiro Ochiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210310077
    Abstract: This invention provides a kit or device for detection of prostate cancer and a method for detecting prostate cancer. This invention provides a kit or device for detection of prostate cancer comprising a nucleic acid capable of specifically binding to an miRNA in a sample from a subject or a complementary strand thereof and a method for detecting prostate cancer comprising measuring the miRNA in vitro.
    Type: Application
    Filed: August 9, 2019
    Publication date: October 7, 2021
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Makiko YOSHIMOTO, Hiroko SUDO, Atsuko MIYANO, Satoko KOZONO, Takahiro OCHIYA, Hiroyuki FUJIMOTO, Fumihiko URABE, Juntaro MATSUZAKI
  • Publication number: 20210230706
    Abstract: This application provides a kit or a device for detection of ovarian tumor, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting ovarian tumor, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 29, 2021
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho KIDA, Satoko KOZONO, Hiroko SUDO, Satoshi KONDOU, Junpei KAWAUCHI, Hitoshi NOBUMASA, Takahiro OCHIYA, Tomoyasu KATO
  • Patent number: 10975444
    Abstract: This application provides a kit or a device for detection of ovarian tumor, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting ovarian tumor, comprising measuring the miRNA(s) in vitro.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 13, 2021
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho Kida, Satoko Kozono, Hiroko Sudo, Satoshi Kondou, Junpei Kawauchi, Hitoshi Nobumasa, Takahiro Ochiya, Tomoyasu Kato
  • Patent number: 10961507
    Abstract: The present invention provides a method for producing hepatic stem/progenitor cells from mammal hepatocytes, comprising bringing a TGF?-receptor inhibitor, and optionally a GSK3 inhibitor and/or a ROCK inhibitor into contact with the hepatocytes in vitro.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: March 30, 2021
    Assignee: Cynity Co., Ltd.
    Inventors: Takahiro Ochiya, Takeshi Katsuda
  • Publication number: 20210079478
    Abstract: Disclosed is a method of assisting the detection of breast cancer, assisting in highly accurate detection of breast cancer. In the method of assisting the detection of breast cancer, the abundance of at least one of miRNAs, isomiRs, precursor miRNAs, or transfer RNA fragments contained in a test sample isolated from a living body and having a specific nucleotide sequence is used as an index. A higher abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of, for example, SEQ ID NOs: 1 to 19, 27, 28, and 34 to 51 than that of healthy subjects or a lower abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of, for example, SEQ ID NOs: 20 to 26, 29 to 33, and 52 to 54 than that of healthy subjects indicates a higher likelihood of having breast cancer.
    Type: Application
    Filed: December 13, 2018
    Publication date: March 18, 2021
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Hidetoshi TAHARA, Takahiro OCHIYA
  • Patent number: 10918590
    Abstract: The purpose of the present invention is to provide an agent for improving skin looseness or aging caused by dermal cavitation. By attracting fat stem cells into cavities in the dermis, dermal fibroblasts around the cavities can be activated and thus dermal cavitation can be ameliorated. As the results of a screening for fat stem cell attractants, it was found that rosemary extract and licorice extract are capable of attracting fat stem cells and, therefore, can improve skin looseness or aging caused by dermal cavitation.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: February 16, 2021
    Assignee: Shiseido Company, Ltd.
    Inventors: Tomonobu Ezure, Takahiro Ochiya
  • Patent number: 10905708
    Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: February 2, 2021
    Inventors: Takahiro Ochiya, Tomohiro Fujiwara
  • Publication number: 20210015843
    Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
    Type: Application
    Filed: April 4, 2019
    Publication date: January 21, 2021
    Inventors: Takahiro Ochiya, Tomohiro Fujiwara
  • Publication number: 20200316105
    Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 8, 2020
    Inventors: Takahiro Ochiya, Tomohiro Fujiwara
  • Publication number: 20200316104
    Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 8, 2020
    Inventors: Takahiro Ochiya, Tomohiro Fujiwara
  • Publication number: 20200291431
    Abstract: Methods for the treatment of cancer that include the step of administering a viral vector carrying a nerve deleting, nerve ablating or nerve inhibiting payload, the administration leading to the deletion, ablation or inhibition of tumor-specific sympathetic nerves.
    Type: Application
    Filed: March 16, 2020
    Publication date: September 17, 2020
    Applicant: Convocation Co., Ltd.
    Inventors: Takahiro Ochiya, Adrian Sack, Hideaki Shiraishi
  • Publication number: 20200255910
    Abstract: It is intended to provide a kit or a device for the detection of breast cancer and a method for detecting breast cancer. The present invention provides a kit or a device for the detection of breast cancer, comprising nucleic acid(s) capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting breast cancer, comprising measuring the miRNA in vitro.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 13, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi KONDOU, Hitoshi NOBUMASA, Satoko KOZONO, Hiroko SUDO, Junpei KAWAUCHI, Takahiro OCHIYA, Nobuyoshi KOSAKA, Makiko ONO, Kenji TAMURA
  • Publication number: 20200216912
    Abstract: A method for suppressing brain metastasis includes administering an miR-181c expression inhibitor, an miR-181c activity inhibitor, or an exosome secretion inhibitor as an active ingredient.
    Type: Application
    Filed: January 17, 2020
    Publication date: July 9, 2020
    Inventors: Takahiro OCHIYA, Naoomi TOMINAGA
  • Publication number: 20200199688
    Abstract: An object of the present invention is to provide a kit or a device for the detection of prostate cancer and a method for detecting prostate cancer. The present invention provides a kit or a device for the detection of prostate cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting prostate cancer, comprising measuring the miRNA in vitro.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 25, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi KONDOU, Hitoshi NOBUMASA, Satoko KOZONO, Hiroko SUDO, Junpei KAWAUCHI, Takahiro OCHIYA, Nobuyoshi KOSAKA
  • Publication number: 20200140956
    Abstract: This application provides a kit or a device for detection of ovarian tumor, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting ovarian tumor, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 7, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho KIDA, Satoko KOZONO, Hiroko SUDO, Satoshi KONDOU, Junpei KAWAUCHI, Hitoshi NOBUMASA, Takahiro OCHIYA, Tomoyasu KATO
  • Publication number: 20200140958
    Abstract: This application provides a kit or a device for detection of lung cancer, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: June 29, 2018
    Publication date: May 7, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho KIDA, Satoko KOZONO, Hiroko SUDO, Satoshi KONDOU, Junpei KAWAUCHI, Takahiro OCHIYA, Shun-ichi WATANABE
  • Patent number: 10619213
    Abstract: An object of the present invention is to provide a kit or a device for the detection of prostate cancer and a method for detecting prostate cancer. The present invention provides a kit or a device for the detection of prostate cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting prostate cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 14, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Takahiro Ochiya, Nobuyoshi Kosaka
  • Patent number: 10597726
    Abstract: It is intended to provide a kit or a device for the detection of breast cancer and a method for detecting breast cancer. The present invention provides a kit or a device for the detection of breast cancer, comprising nucleic acid(s) capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting breast cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 24, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Takahiro Ochiya, Nobuyoshi Kosaka, Makiko Ono, Kenji Tamura
  • Patent number: 10561122
    Abstract: The present invention provides a rat embryonic stem cell characterized by having the following properties of (a) expressing Oct3/4 gene and Nanog gene, (b) positive for alkaline phosphatase activity, (c) having an embryoid body forming ability, (d) expressing SSEA (Stage-Specific Embryonic Antigen)-1 and SSEA-4, (e) having the same number of chromosomes as does a normal rat cell, (f) capable of being subcultured and holding the undifferentiated state, (g) having in vitro pluripotency, (h) having a potential to differentiate for cells of three embryonic germ lineages, (i) having teratoma formation ability, and (j) having an ability to produce a chimeric rat, a method of establishing the aforementioned rat embryonic stem cell and the like.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: February 18, 2020
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, National Cancer Center
    Inventors: Takumi Teratani, Takahiro Ochiya
  • Patent number: 10544466
    Abstract: A method increases permeability of a blood-brain barrier in a subject. The method includes administering a small interfering ribonucleic acid (siRNA) against the 3-Phosphoinositide Dependent Protein Kinase 1 (PDPK1) gene or micro ribonucleic acid (miRNA) miR-181c as an active ingredient to the subject. The method can be applied for delivering a desired active agent to the subject.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 28, 2020
    Assignees: Gene Techno Science Co., Ltd., National Cancer Center, Theoria Science Inc.
    Inventors: Takahiro Ochiya, Naoomi Tominaga