Abstract: To solve the above-mentioned problems, the present inventors introduced site-specific mutations into sc(Fv)2 and examined the stabilizing effects on sc(Fv)2. As a result, they succeeded for the first time in significantly increasing the Tm value of sc(Fv)2 by amino acid substitutions. Furthermore, they discovered that sc(Fv)2 is stabilized by introducing site-specific mutations into sc(Fv)2.

Abstract: The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(?O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical co

Abstract: A semiconductor integrated circuit includes one or more function blocks, a nonvolatile memory unit which stores therein coded license information, and a decoder circuit which decodes the license information stored in the nonvolatile memory unit, and makes one of the function blocks either usable or unusable depending on the decoded license information.

Abstract: A joint for piping includes a pipe with an annular swelling wall and a connector body with a socket that includes locking pieces. The locking pieces hold the annular swelling wall when the pipe is inserted through the connector body to connector the pipe to the connector body. A projected member on the pipe fits in a recess on the connector body to prevent rotation between the pipe and the connector body.

Abstract: A joint for piping includes a pipe with an annular swelling wall and a connector body with a socket that includes locking pieces. The locking pieces hold the annular swelling wall when the pipe is inserted through the connector body to connector the pipe to the connector body. A projected member on the pipe fits in a recess on the connector body to prevent rotation between the pipe and the connector body.

Abstract: A semiconductor integrated circuit includes one or more function blocks, a nonvolatile memory unit which stores therein coded license information, and a decoder circuit which decodes the license information stored in the nonvolatile memory unit, and makes one of the function blocks either usable or unusable depending on the decoded license information.

Abstract: 2,2,4,4,6-Pentamethyl-2,3,4,5-tetrahydropyrimidine, called acetonin, is prepared by reacting acetone with ammonia in the presence of an ammonium halide catalyst and in the presence of from 0.01 to 0.5 mole % (based on acetone) of a promoter selected from the group consisting of: bromine; iodine; iodine trichloride; alkali metal iodides; lithium rhodanide, bromide, nitrate and cyanide; ammonium iodide, rhodanide, bromide, nitrate and sulfide; ammonium salts of carboxylic acids and of sulfonic acids; salts of nitrogen-containing organic bases with carboxylic acids and with sulfonic acids; aliphatic amine hydroiodides; carboxylic acids; and sulfonic acids.