Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.

Abstract: An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R1 represents CO2R, CO2M, or CONH2, wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.

Abstract: A rechargeable battery includes an electrode assembly including a positive electrode and a negative electrode, a case for accommodating the electrode assembly, a cap plate combined to the case, a vent plate disposed under the cap plate and formed with a notch, a middle plate disposed under the vent plate, and a heat-resistant insulating layer disposed between the vent plate and the middle plate.

Abstract: A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.

Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.

Abstract: One aspect of the present invention provides a rechargeable battery that is capable of preventing a vent from being oxidized by preserving a plating layer of a surface of a vent. An exemplary embodiment of the present invention provides a rechargeable battery, including: an electrode assembly for performing charging and discharging operations; a case for accommodating the electrode assembly; and a cap assembly combined to an opening of the case and sealing the case. The case includes a vent at one side, and the vent has a plurality of ends in a thickness direction of the case and includes a plating layer on its surface.

Abstract: A rechargeable battery includes an electrode assembly including a positive electrode and a negative electrode, a case receiving the electrode assembly, a cap plate coupled to the case, a vent plate under the cap plate, the vent plate including a notch, a middle plate under the vent plate, and a laminating insulating layer between the vent plate and the middle plate, the laminating insulating layer being laminated to the vent plate or the middle plate.

Abstract: A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O?, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.

Abstract: A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O?, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.

Abstract: A rechargeable battery including an electrode assembly; a case accommodating the electrode assembly; and a cap assembly coupled with an opening of the case with a gasket between the cap assembly and the case, wherein the cap assembly includes a vent plate that is electrically connected to a cap plate; a middle plate that is separated from the vent plate, that includes a through-hole that is penetrated by a vent protruding from the vent plate, and that is electrically connected to the second electrode; an insulator interposed between the vent plate and the middle plate; and a sub-plate electrically connecting the vent with the middle plate, wherein at least one of the vent plate or the middle plate includes a protrusion and a groove facing the insulator, the protrusion being coupled with a complementary groove in the insulator and the groove being coupled with a complementary protrusion in the insulator.

Abstract: A secondary battery includes an electrode assembly having a first electrode plate, a second electrode plate and a separator interposed between the first and second electrode plates; a lower case accommodating the electrode assembly therein; and a cap assembly sealing the lower case. In the secondary battery, the lower case has the electrode assembly and a vent portion, and includes a surface facing the cap assembly. The vent portion includes an intersecting portion formed inside the surface, first and second curved portions curved to extend from the intersecting portion, and an extending portion extended in a straight line from the intersecting portion. The thickness of the intersecting portion includes the minimum thickness of the surface.

Abstract: A compound of the following compound (B): , wherein tBu represents a tert-butyl group. A compound of the following compound (C): , wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.

Abstract: An objective of the present invention is to provide a novel NDM (New Delhi metallo-?-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of ?-lactam antibiotics that have been inactivated as a result of decomposition by NDM.

Abstract: A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O?, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.

Abstract: A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.

Abstract: A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.

Abstract: The present invention is a single-crystal manufacturing apparatus based on the Czochralski method having a main chamber configured to accommodate hot zone components including a crucible, and a pull chamber configured to accommodate and take out a single crystal pulled from a raw material melt, the apparatus further comprising a multipurpose chamber interchangeable with the pull chamber, wherein a heating means for heating a raw material charged into the crucible and a cooling means for cooling the hot zone components after pulling the single crystal are placeable in the multipurpose chamber respectively. As a result, there is provided a single-crystal manufacturing apparatus that enables, in manufacture of a single crystal of a large diameter, e.g., approximately 200 mm or more, an operating rate of the single-crystal manufacturing apparatus and productivity of the single crystal to be improved.

Abstract: An objective of the present invention is to provide a novel NDM (New Delhi metallo-?-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of ?-lactam antibiotics that have been inactivated as a result of decomposition by NDM.

Abstract: A secondary battery includes an electrode assembly having a first electrode plate, a second electrode plate and a separator interposed between the first and second electrode plates; a lower case accommodating the electrode assembly therein; and a cap assembly sealing the lower case. In the secondary battery, the lower case has the electrode assembly and a vent portion, and includes a surface facing the cap assembly. The vent portion includes an intersecting portion formed inside the surface, first and second curved portions curved to extend from the intersecting portion, and an extending portion extended in a straight line from the intersecting portion. The thickness of the intersecting portion includes the minimum thickness of the surface.

Abstract: A magnetic disk device includes a magnetic disk on which servo information is recorded, a head to read the servo information of the magnetic disk, and a position control module. When carrying out positioning control of the head, the position control module estimates frequency components of noise in a head positioning control process, using a high-order digital filter that includes first and second variable coefficients that are each based on position error information generated from the servo information read by the head.