Abstract: A pad support spring includes a U-shaped portion comprising an outer peripheral surface portion, an inner peripheral surface portion and a linking surface portion. The U-shaped portion is configured to include: a pad holding portion; a cutout portion provided by cutting out a part from the linking surface portion toward the inner peripheral surface portion; a tongue piece portion which in an unassembled state has a base end formed by the cutout portion on the outer peripheral surface portion side of the pad holding portion and a distal end which projects out from an opposing surface of the inner peripheral surface portion, and which in an assembled state deforms elastically to press a brake pad in conjunction with the U-shaped portion; and a first slit portion provided by cutting out part of a first linking part.

Abstract: A pad support spring includes a U-shaped portion comprising an outer peripheral surface portion, an inner peripheral surface portion and a linking surface portion. The U-shaped portion is configured to include: a pad holding portion; a cutout portion provided by cutting out a part from the linking surface portion toward the inner peripheral surface portion; a tongue piece portion which in an unassembled state has a base end formed by the cutout portion on the outer peripheral surface portion side of the pad holding portion and a distal end which projects out from an opposing surface of the inner peripheral surface portion, and which in an assembled state deforms elastically to press a brake pad in conjunction with the U-shaped portion; and a first slit portion provided by cutting out part of a first linking part.

Abstract: An object is to stably exhibit a two-stage spring characteristic of a plate spring for restraining the generation of a clonk noise in a disc brake apparatus for use in a vehicle. A plate spring 90 for restraining the generation of a clonk noise has a fixture portion 91 having a shape resembling the squarish letter U and elastically fixed to a back plate 61, and an extension portion 92 extending continuously from the fixture portion 91. The extension portion 92 includes an engagement subportion 92a engaged with a support member at all times; a curved subportion 92b located between the engagement subportion 92a and the fixture portion 91; and a contact-engagement subportion 92c located between the curved subportion 92b and the fixture portion 91.

Abstract: An object is to stably exhibit a two-stage spring characteristic of a plate spring for restraining the generation of a clonk noise in a disc brake apparatus for use in a vehicle. A plate spring 90 for restraining the generation of a clonk noise has a fixture portion 91 having a shape resembling the squarish letter U and elastically fixed to a back plate 61, and an extension portion 92 extending continuously from the fixture portion 91. The extension portion 92 includes an engagement subportion 92a engaged with a support member at all times; a curved subportion 92b located between the engagement subportion 92a and the fixture portion 91; and a contact-engagement subportion 92c located between the curved subportion 92b and the fixture portion 91.

Abstract: The invention provides a compound represented by the following formula (I) wherein m is an integer of 2-15; n is an integer of 0-12; R represents a sugar chain or a derivative thereof; R′ represents a general formula (II) (wherein p is an integer of 0-4, q is an integer of 0-5; r is an integer of 2-5; R12 and R13 are the same or different and each represents a hydrogen atom, a lower alkyl group, an aliphatic acyl group, a nitro group or a nitrile group), R1 represents a hydrogen atom or a protective group of carboxylic acid, R2, R4 and R5 are the same or different and each represents a hydrogen atom, an aliphatic or aromatic acyl group; R3 represents an acetyl group, a glycolyl group or a trifluoroacetyl group; useful as reagent for detecting influenza virus A.

Abstract: 2-Fluorofucosyl-N-aroylglucosamine derivatives which are obtained by substitution of a hydroxyl group at the 3- or 4-position of N-aroylglucosamine with 2-fluorofucose, their intermediates and preparation methods thereof. The 2-fluorofucosyl-N-aroylglucosamine derivatives which are useful medicinal components for the treatment, improvement and prevention of inflammation and diseases accompanying inflammation, their intermediates and preparation methods thereof can be provided.

Abstract: A novel fluorine-containing Lewis X derivative represented by the following formula (I): ##STR1## wherein R represents hydrogen, a hydroxyl-protective group, --PO(OH).sub.2, --SO.sub.3 H or sialylate;R.sup.1 represents hydrogen, hydroxyl, aliphatic acyloxy, aromatic acyloxy, lower alkylthio, optionally substituted phenylthio, lower alkoxy, branched long chain alkoxy, optionally substituted phenylmethoxy or sphingosinyl, R.sup.10 represents hydrogen or --O--C--(.dbd.NH)CCl.sub.3 ; provided that when R.sup.10 is --O--C--(.dbd.NH)CCl.sub.3, R.sup.9 is hydrogen;R.sup.2 and R.sup.3 are the same or different and independently represent hydrogen, aliphatic acyl, aromatic acyl or optionally substituted phenylmethyl; andR.sup.4 represents hydroxyl, aliphatic acyloxy, aromatic acyloxy, aliphatic acylamino or aromatic acylamino.

Abstract: A sialyl Lewis X derivative represented by the general formula: ##STR1## in which a hydroxyl group at the 2 position of fucose is replaced with a fluorine atom, and a synthetic intermediate therefor are provided.

Abstract: A ganglioside GM3 derivative having a fluorine atom at the 9-position of sialic acid represented by the formula: ##STR1## wherein R is an aliphatic lower acyl group, R.sup.1 is a hydrogen atom or a lower alkyl group, R.sup.2 to R.sup.5 represent independently of one another a hydrogen atom, an aliphatic lower acyl group or an aromatic acyl group, R.sup.11 is an straight or branched, saturated or unsaturated aliphatic hydrocarbon group having 1 to 30 carbon atoms, and n is an integer of 0 to 20, provided that when R.sup.1 is a hydrogen atom, R.sup.2 to R.sup.5 are hydrogen atoms, or when R.sup.1 is a lower alkyl group, R.sup.2 to R.sup.5 are each an aliphatic lower acyl group or an aromatic acyl group, and intermediates therefor. This compound is useful as an agent for preventing infection of the influenza virus, an agent for preventing proliferation and metastasis of the cancer cells, etc.

Abstract: A novel fluorine-substituted ganglioside GM3 derivative represented by the formula (I): ##STR1## wherein R is an aliphatic acyl group, R.sup.1 is a hydrogen atom or a lower alkyl group, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 represent independently of one another a hydrogen atom, an aliphatic lower acyl group or an aromatic acyl group, R.sup.5 is an straight or branched, saturated or unsaturated aliphatic hydrocarbon group having 1 to 30 carbon atoms, and n is an integer of 0 to 20, provided that when R.sup.1 is a hydrogen atom, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are hydrogen atoms, or when R.sup.1 is a lower alkyl group, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are each an aliphatic lower acyl group or an aromatic acyl group.

Abstract: A ganglioside derivative in which a ceramide moiety is labeled with a fluorescent dye represented by the formula (I): ##STR1## wherein --O--R--O-- is a saccharide chain constituting the ganglioside, R' is an ether, sulfide, amide, urethane, thiourea or amino group having a fluorescent dye, one of R.sup.5 or R.sup.6 is a single bond and the other is a hydrogen atom, I is an integer of 1 to 8, m is an integer of at least 2, and n is an integer of 0 to 12. This ganglioside derivative has recognition characteristics of the saccharide chain portion and the labeling property of the fluorescent dye introduced in the ceramide moiety, and is useful as an agent for monitoring the dynamic behavior of the receptor for glycolipids, a diagnostic agent for bacteria or viruses, and the like.

Abstract: The invention pertains to 2,7-Deoxy-7-fluoro-2,3-didehydrosialic acid and an intermediate thereof which are useful for developing practical drugs, such as an antiviral agent, a preventing agent for viral diseases, etc. and for a clinical application. In addition, they are also useful as a carcinostatic agent and an immunomodulation agent.

Abstract: A ganglioside GM3 derivative containing fluorine atoms in a ceramide portion thereof, represented by the formula: ##STR1## in which m is an integer of at least 2, n is an integer of 0 to 7 provided that m is larger than n, and R represents an alkyl group or a fluoroalkyl group is disclosed.

Abstract: The present invention relates to N-acylglutamine derivatives of formula (I): ##STR1## The N-acylglutamine derivatives are well compatible with oily bases and have good skin-moisturizing activity and hair growth-stimulative effect. These are useful as cosmetics and hair growth stimulants.

Abstract: A hydroxamic acid compound represented by the general formula (I) or a salt thereof; ##STR1## wherein R.sup.1 represents a hydrogen atom, or a substituted or unsubstituted alkanoyl group, R.sup.2 represents an unsubstituted alkanoyl, substituted lower alkanoyl or substituted lower alkyl group, and m represents an integer of 3 to 7, which are useful for the prevention and/or treatment of diseases caused by lipoxygenase-mediated metablites.

Abstract: A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

Abstract: UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.

Abstract: Hexafluoroacetone hydrate is obtained with a high current efficiency by electrolytically oxidizing dimer or monomer of hexafluoro-.alpha.-hydroxyisobutanoic acid in an electrolytic solution composed of an aqueous solution of (1) a nickel salt and (2) HCl, HBr or an alkali metal or alkaline earth metal thereof.

Abstract: A preventive and healing composition for diseases due to lipoxygenase metabolic products, which comprises an effective amount of a compound represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 15 carbon atoms and at least one pharmaceutically acceptable carrier.

Abstract: A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.