Abstract: In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.

Abstract: The invention is directed to a light-emission detection apparatus for individually condensing light emitted from each emission point of a emission-point array using each condensing lens of a condensing-lens array to form a light beam and detecting each light beam incident on a sensor in parallel, and the light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.

Abstract: Conventionally, only a pair of electrodes is provided and nanopores arranged in parallel are connected by an electrolyte solution, and therefore a change in anion current to be measured is a sum of changes in ion currents generated in the respective nanopores.

Abstract: A light detection device comprises: a flow path section in which a plurality of lines of flow of a plurality of droplets 4 dispersed in oil and moving along a linear line of flow is retained on an array plane; a laser beam irradiation section which introduces a laser beam 3 in a direction in which the plurality of lines of flow are arrayed in the flow path section to irradiate the plurality of lines of flow; and a light detection section which detects emitted light generated from the plurality of lines of flow by the irradiation of the laser beam, from a vertical direction with respect to the array plane. A refractive index of the oil no and a refractive index of the droplets nd have a difference such that ?0.02?nd?no?0.05.

Abstract: In order to avoid crosstalk between images by a simple method, an optical system through which lights emitted from a plurality of light emission points pass, and a measurement unit that measures lights imaged by the optical system are provided, and a midpoint of two arbitrary light emission points among the light emission points is shifted away from a center of the optical system. More specifically, the center of the optical system exists outside a light emission point group consisting of the plurality of the light emission points. With the above configuration, main images and ghost images are separated each other, and thus, it is possible to avoid crosstalk caused by ghosting and to correctly analyze emissions from the plurality of the light emission points.

Abstract: Conventionally, only a pair of electrodes is provided and nanopores arranged in parallel are connected by an electrolyte solution, and therefore a change in an ion current to be measured is a sum of changes in ion currents generated in the respective nanopores.

Abstract: In order to avoid crosstalk between images by a simple method, an optical system through which lights emitted from a plurality of light emission points pass, and a measurement unit that measures lights imaged by the optical system are provided, and a midpoint of two arbitrary light emission points among the light emission points is shifted away from a center of the optical system. More specifically, the center of the optical system exists outside a light emission point group consisting of the plurality of the light emission points. With the above configuration, main images and ghost images are separated each other, and thus, it is possible to avoid crosstalk caused by ghosting and to correctly analyze emissions from the plurality of the light emission points.

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

Abstract: An analysis system includes an analyzer configured to separate a sample including a plurality of components labeled with any of M kinds of fluorescent substances by chromatography and acquire first time-series data of fluorescence signals detected in N kinds (M>N) of wavelength bands in a state in which at least a part of the plurality of components is not completely separated; and a computer configured to compare the first time-series data with the second time-series data, and determine which kind of fluorescent substance of M kinds of fluorescent substances individually labels each of the plurality of components.

Abstract: An aspect of the present invention includes performing electrophoresis of a nucleic acid sample to be analyzed labeled for each base type, generating waveform data of detected intensity by detecting a label signal for the each base type, selecting another peak position for each peak position of the waveform data for each base type, calculating relative signal intensity of signal intensity in each position relative to the signal intensity in the other selected position, and analyzing existence of each base type in a base sequence coordinate position of the nucleic acid sample by comparing the relative signal intensity of the nucleic acid sample to be analyzed and the relative signal intensity of a known nucleic acid sample in each peak position. Accordingly, acquiring information about a gene mutation in trace amounts existing in a target gene region highly sensitively with high precision is realized.

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

Abstract: The purpose of the present invention is to provide a DNA transport control device having excellent reliability and durability, and a DNA sequencing device that uses the DNA transport control device. The present invention provides a DNA transport control device having a nanopore which allows for the passage of only the DNA strand of a single molecule, and a DNA sequencing device that uses the DNA transport control device. The DNA transport control device is characterized by the following: including a base material having openings and a thin film a block copolymer formed on the base material; the thin film including microdomains that are formed as a result of self-assembly of the block copolymer and that penetrate the thin film, and a matrix surrounding the microdomains; and the nanopore being formed from one opening in the base material and a single microdomain.

Abstract: A dichroic mirror array in which a plurality of dichroic mirrors are arranged, and by satisfying a predetermined relationship between a width, a thickness, a material, a tilt, an interval, and a step difference of each dichroic mirror, the dichroic mirror array is miniaturized, an optical path length is reduced, and at the same time, an opening width is increased.

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

Abstract: In the field of the next generation DNA sequencer, a method for integrating very high sensitive FET sensors having side gates and nanopores as devices used for identifying four kinds of base and for mapping the base sequence of DNA without using reagents, and a semiconductor device having selection transistors and amplifier transistors respectively corresponding to the FET sensors having side gates and nanopores respectively so as to be able to read the variation of a detection current based on the differences among the charges of the four kinds of base without deteriorating the detection sensitivity of the FET sensor, are presented.

Abstract: A light detection device comprises: a flow path section in which a plurality of lines of flow of a plurality of droplets 4 dispersed in oil and moving along a linear line of flow is retained on an array plane; a laser beam irradiation section which introduces a laser beam 3 in a direction in which the plurality of lines of flow are arrayed in the flow path section to irradiate the plurality of lines of flow; and a light detection section which detects emitted light generated from the plurality of lines of flow by the irradiation of the laser beam, from a vertical direction with respect to the array plane. A refractive index of the oil no and a refractive index of the droplets nd have a difference such that ?0.02?nd?no?0.05.

Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2<n1) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channel 2 is configured by a trapezoidal shape of upper base>lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2<n1) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channel 2 is configured by a trapezoidal shape of upper base>lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.

Abstract: The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (100a) characterized by comprising: a solid substrate (110); at least one nanopore (120) disposed in the solid substrate (110); and one or more electrically conductive thin films (130a, 130b) disposed on the solid substrate (110). The biopolymer property analysis chip (100a) is characterized in that the electrically conductive thin films (130a, 130b) are disposed partially on the solid substrate (110) where the nanopore (120) is formed and a biopolymer which has penetrated into the nanopore (120) is caused to generate Raman scattered light by means of irradiation with external light.