Patents by Inventor Takashi Furutani
Takashi Furutani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8197818Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: GrantFiled: April 13, 2011Date of Patent: June 12, 2012Assignees: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Patent number: 8164261Abstract: A plasma display panel includes a front plate and a rear plate disposed so as to face the front plate. A discharge space is formed between the front plate and the rear plate. The front plate includes display electrodes and a dielectric layer formed to coat the display electrodes. The dielectric layer includes hollow fine particles which are hollowed out inside.Type: GrantFiled: February 15, 2011Date of Patent: April 24, 2012Assignee: Panasonic CorporationInventors: Takashi Furutani, Yukako Doi, Yasuhiko Nakada, Hiroyuki Ajiki
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Publication number: 20120001540Abstract: A plasma display panel includes a front plate and a rear plate disposed so as to face the front plate. A discharge space is formed between the front plate and the rear plate. The front plate includes display electrodes and a dielectric layer formed to coat the display electrodes. The dielectric layer includes hollow fine particles which are hollowed out inside.Type: ApplicationFiled: February 15, 2011Publication date: January 5, 2012Inventors: Takashi Furutani, Yukako Doi, Yasuhiko Nakada, Hiroyuki Ajiki
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Publication number: 20110282066Abstract: [Object] A screening method for a compound which is useful as an agent for treating 17?HSD type 5-related diseases and/or an agent for treating 17?HSD type 5-related cancer such as prostate cancer is provided. [Means for Solution] The present invention has been completed by establishing a screening method for a compound which is useful for treating 17?HSD type 5-related diseases, by manifesting a tumor by transplanting tumor cells to, for example, an immunodeficient mouse, topically administering a steroid which is a biosynthetic substance for a hormone into the tumor, and measuring the level of a hormone produced in the tumor.Type: ApplicationFiled: January 26, 2010Publication date: November 17, 2011Inventors: Takashi Furutani, Kentaro Enjo, Aya Kikuchi, Sadao Kuromitsu, Yukitaka Ideyama, Tomoyuki Suzuki, Ryoko Kurihara
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Publication number: 20110230545Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: ApplicationFiled: April 13, 2011Publication date: September 22, 2011Applicants: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Patent number: 7964710Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: GrantFiled: May 15, 2009Date of Patent: June 21, 2011Assignees: Astellas Pharma Inc., CureGene K. K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Publication number: 20110071146Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.Type: ApplicationFiled: November 10, 2010Publication date: March 24, 2011Inventors: Tatsuya Niimi, Akio Kamikawa, Yasushi Amano, Tomohiko Yamaguchi, Kenichi Suzumura, Kentaro Enjo, Takashi Furutani, Akio Kakefuda, Yutaka Kondoh, Masaaki Hirano
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Patent number: 7855225Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.Type: GrantFiled: March 1, 2007Date of Patent: December 21, 2010Assignee: Astellas Pharma Inc.Inventors: Tatsuya Niimi, Akio Kamikawa, Yasushi Amano, Tomohiko Yamaguchi, Kenichi Suzumura, Kentaro Enjo, Takashi Furutani, Akio Kakefuda, Yutaka Kondoh, Masaaki Hirano
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Publication number: 20100240673Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: ApplicationFiled: May 15, 2009Publication date: September 23, 2010Applicants: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki MANO, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Publication number: 20100190826Abstract: Provided is a novel and excellent method for treating and/or preventing benign prostatic hyperplasia, prostate cancer, and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an indole or benzimidazole derivative, where a nitrogen atom of the indole ring or benzimidazole ring is substituted with a phenyl group substituted with COOH, has a potent selective inhibitory activity against 17?HSD type 5 and may become an agent for treating and/or an agent for preventing a disease associated with 17?HSD type 5, such as benign prostatic hyperplasia, prostate cancer and the like, without accompanying adverse effects due to a decrease in testosterone; and the present invention has thus been completed.Type: ApplicationFiled: July 23, 2008Publication date: July 29, 2010Inventors: Akio Kakefuda, Yutaka Kondoh, Masaaki Hirano, Akio Kamikawa, Kentaro Enjo, Takashi Furutani
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Patent number: 7728120Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: GrantFiled: August 27, 2007Date of Patent: June 1, 2010Assignees: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Publication number: 20100099658Abstract: The present invention provides a compound which is useful as an inhibitor against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. As a result of extensive and intensive studies on compounds having an inhibitory effect against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins, the inventors of the present invention have found that the di(arylamino)aryl compound of the present invention has inhibitory activity against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. This finding led to the completion of the present invention.Type: ApplicationFiled: July 4, 2008Publication date: April 22, 2010Applicant: ASTELLAS PHARMA INC.Inventors: Yutaka Kondoh, Kazuhiko Iikubo, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani, Itsuro Shimada, Takahiro Matsuya, Kazuo Kurosawa, Akio Kamikawa, Hiroyuki Mano
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Patent number: 7666873Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: GrantFiled: September 26, 2007Date of Patent: February 23, 2010Assignee: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Takenori Kimura, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Patent number: 7605131Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, and a therapeutic agent for cancer.Type: GrantFiled: April 10, 2008Date of Patent: October 20, 2009Assignees: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Publication number: 20090181960Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.Type: ApplicationFiled: March 1, 2007Publication date: July 16, 2009Inventors: Tatsuya Niimi, Akio Kamikawa, Yasushi Amano, Tomohiko Yamaguchi, Kenichi Suzumura, Kentaro Enjo, Takashi Furutani, Akio Kakefuda, Yutaka Kondoh, Masaaki Hirano
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Publication number: 20090099193Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, and a therapeutic agent for cancer.Type: ApplicationFiled: April 10, 2008Publication date: April 16, 2009Applicants: Astellas Pharma Inc., CureGene KKInventors: Hiroyuki MANO, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Publication number: 20080214543Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: ApplicationFiled: September 26, 2007Publication date: September 4, 2008Applicant: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Patent number: 7365479Abstract: The present invention provides an optical filter for a display device capable to improve the bright-location contrast, and a display device in particular a plasma display device incorporating the optical filter. In a transmittance spectrum of the optical filter, a transmittance in a region having a wavelength range of 430 nm to 445 nm, a transmittance in a region having a wavelength range of 535 to 560 nm, and a transmittance in a region having a wavelength range of 605 to 630 nm are set to 80% or less of the maximum transmittance over the entire visible wavelength region.Type: GrantFiled: May 17, 2005Date of Patent: April 29, 2008Assignee: Pioneer Plasma Display CorporationInventors: Tadahiko Kanoh, Takashi Furutani
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Publication number: 20080090776Abstract: The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.Type: ApplicationFiled: August 27, 2007Publication date: April 17, 2008Applicants: Astellas Pharma Inc., CureGene K.K.Inventors: Hiroyuki Mano, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani
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Patent number: 7297698Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: GrantFiled: July 11, 2003Date of Patent: November 20, 2007Assignee: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Takenori Kimura, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani