Patents by Inventor Takashi Ootsuka
Takashi Ootsuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120059187Abstract: According to the present invention, there is provided a production process of a 2-fluoroacrylic ester including: a bromination step of converting a 2-fluoropropionic ester to a 2-bromo-2-fluoropropionic ester by reaction of the 2-fluoropropionic ester with a nitrogen-bromine bond-containing brominating agent in the presence of a radical initiator; and a dehydrobromination step of reacting the 2-bromo-2-fluoropropionic ester with a base. It is not necessary in this process to adopt very-low-temperature conditions and to use a stoichiometric amount of expensive reagent. The target 2-fluoroacrylic ester can be thus produced at low cost.Type: ApplicationFiled: March 23, 2010Publication date: March 8, 2012Applicant: Central Glass Company, LimitedInventors: Akihiro Ishii, Takako Yamazaki, Hideyuki Tsuruta, Satoru Miyazawa, Michitaka Ootani, Takashi Ootsuka, Mikihiro Takahashi, Masataka Fujimoto
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Patent number: 8058412Abstract: There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2?-deoxy-2?-fluorouridine derivatives, optically-active ?-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.Type: GrantFiled: June 25, 2007Date of Patent: November 15, 2011Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Takashi Ootsuka, Manabu Yasumoto, Hideyuki Tsuruta, Kenjin Inomiya, Koji Ueda, Kaori Mogi
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Publication number: 20110092747Abstract: Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.Type: ApplicationFiled: June 26, 2009Publication date: April 21, 2011Applicants: TOKYO INSTITUTE OF TECHNOLOGY, CENTRAL GLASS COMPANY, LIMITEDInventors: Takao Ikariya, Masato Ito, Akira Shiibashi, Takashi Ootsuka
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Publication number: 20100267940Abstract: There is disclosed a method for producing a 4-deoxy-4-fluoro-D-glucose derivative by reacting a D-galactose derivative with either sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or perfluorobutanesulfonyl fluoride (C4F9SO2F) in the presence of an organic base or in the presence of an organic base and a salt or complex of an organic base and hydrogen fluoride.Type: ApplicationFiled: November 26, 2008Publication date: October 21, 2010Inventors: Akihiro Ishii, Manabu Yasumoto, Takashi Ootsuka, Yasuko Nigorikawa
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Patent number: 7807858Abstract: It was found that a fluoro derivative can be produced by reacting a hydroxy derivative with sulfuryl fluoride (SO2F2) in the presence of an organic base or in the presence of an organic base and “a salt or complex comprising an organic base and hydrogen fluoride”. According to the present production process, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in industrial use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, specifically 4-fluoroproline derivatives, 2?-deoxy-2?-fluorouridine derivatives, optically-active ?-fluorocarboxylate derivatives, and the like, even in a large scale.Type: GrantFiled: March 17, 2006Date of Patent: October 5, 2010Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Takashi Ootsuka, Manabu Yasumoto, Hideyuki Tsuruta, Kenjin Inomiya, Koji Ueda, Kaori Mogi
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Patent number: 7663999Abstract: A disc drive apparatus is adapted to be driven when incorporated into a host appliance provided with a see-through section and comprises a disc receiving section for receiving a disc-shaped recording medium, a disc rotary drive mechanism for driving the disc-shaped recording medium to rotate, a recording and/or reproduction mechanism for recording information signals on and/or reproducing information signals from the disc-shaped recording medium and an apparatus main body arranged in correspondence to the see-through section formed in the host appliance and provided with a see-through hole exposing part of the disc-shaped recording medium placed on the disc receiving section to the outside of the host appliance by way of the see-through section.Type: GrantFiled: January 24, 2005Date of Patent: February 16, 2010Assignee: Sony CorporationInventors: Kiyoshi Omori, Takashi Ootsuka, Kunitaka Nerome, Hiroyuki Fukuchi, Manabu Yoshii, Koji Natsubori, Yoko Maruyama, Tatsuya Isoda, Tsuyoshi Abiko
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Publication number: 20090312574Abstract: An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing ?-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost.Type: ApplicationFiled: December 18, 2007Publication date: December 17, 2009Applicants: Central Glass Company, Limited, Tokyo Institute of TechnologyInventors: Koichi Mikami, Kohsuke Aikawa, Akihiro Ishii, Kaori Mogi, Takashi Ootsuka
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Publication number: 20090250658Abstract: There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2?-deoxy-2?-fluorouridine derivatives, optically-active ?-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.Type: ApplicationFiled: June 25, 2007Publication date: October 8, 2009Applicant: Central Glass Company, LimitedInventors: Akihiro Ishii, Takashi Ootsuka, Manabu Yasumoto, Hideyuki Tsuruta, Kenjin Inomiya, Koji Ueda, Kaori Mogi
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Patent number: 7594240Abstract: The present invention is directed to a disk drive apparatus in which an optical disk (2) is detachably loaded, and comprises a casing (3) including a front panel (18) in which a disk insertion/withdrawal hole (19) of which length in length direction is caused to be substantially the same as the diameter of the optical disk, and a biasing member (70) for biasing plural rotational arms (61), (62) for holding the outer circumference of the optical disk therebetween in a predetermined direction in accordance with carrying position of the optical disk, wherein, between the disk insertion/withdrawal position and the disk loading position, there are provided a disk carrying mechanism (60) for performing carrying operation of the optical disk, a disk loading portion (41) to which the optical disk is loaded, a disk rotation drive mechanism (42) for optical disk, an optical pick-up (43) for performing recording and/or reproduction of information signals with respect to the optical disk, and a pick-up feed mechanism (44Type: GrantFiled: April 12, 2006Date of Patent: September 22, 2009Assignee: Sony CorporationInventors: Kiyoshi Omori, Yuji Suzuki, Takashi Ootsuka, Keiji Jitsukawa, Satoshi Muto, Koji Natsubori, Hidekuni Aizawa
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Patent number: 7467395Abstract: A disc drive device which can discharge a disc in an optimum discharge amount in the disc drive device dealing with discs having different thickness and weight. A disc drive device including a disc conveying mechanism formed with a supporting portion to support the optical disc, and having a plurality of arms rotatably supported in the housing, and an energizing member for rotatably energizing the plurality of the rotary arms in a predetermined direction, and conveying the optical disc between a disc mounting position for holding the optical disc inserted into the housing in the disc holding portion and a disc insertion/removal position for inserting/removing the optical disc, the top cover having a control portion for controlling a rotary region of the plurality of rotary arms which energizes the optical disc in the discharging direction by contact with the plurality of rotary arms supporting the outer peripheral surface of the disc.Type: GrantFiled: October 31, 2005Date of Patent: December 16, 2008Assignee: Sony CorporationInventors: Kiyoshi Omori, Yuji Suzuki, Takashi Ootsuka, Keiji Jitsukawa, Satoshi Muto, Koji Natsubori, Hidekuni Aizawa
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Patent number: 7462734Abstract: The present invention relates to a process for producing an optically active ?-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active ?-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.Type: GrantFiled: August 5, 2005Date of Patent: December 9, 2008Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Hideyuki Tsuruta, Takashi Ootsuka, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Koji Ueda
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Patent number: 7459586Abstract: The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII [Chem. 59] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] [Chem. 60] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].Type: GrantFiled: February 21, 2005Date of Patent: December 2, 2008Assignee: Central Glass Company LimitedInventors: Akihiro Ishii, Masatomi Kanai, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Takashi Ootsuka, Katsuhide Suto, Koji Ueda
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Patent number: 7409695Abstract: A disc drive apparatus comprises a housing; a disc-holding unit that holds an optical disc in the housing; a disc-driving mechanism that rotates the optical disc held by the disc-holding unit; an optical pickup that writes signals in, and reads signals from, the optical disc being rotated by the disc-driving mechanism; and a pickup-moving mechanism that moves the optical pickup in a radial direction of the optical disc. The housing has an air-inlet port which is located above the optical disc held by the disc-holding unit and through which air is drawn from outside by virtue of an airflow that develops as the optical disc is rotated, and air-outlet ports through which air is discharged from the housing.Type: GrantFiled: February 22, 2005Date of Patent: August 5, 2008Assignee: Sony CorporationInventors: Kiyoshi Omori, Yuji Suzuki, Takashi Ootsuka, Satoshi Muto, Manabu Yoshii, Koji Natsubori, Hiroyuki Fukuchi
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Patent number: 7393979Abstract: The present invention relates to a process for producing an optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine, which is an important intermediate of medicines and agricultural chemicals, and which is represented by the formula [3] [in the formula R represents a lower alkyl group of a carbon and * represents an asymmetric carbon], or its salt by subjecting an optically active imine represented by the formula [1] to an asymmetric reduction under hydrogen atmosphere using a metal catalyst of Group VIII to convert it into an optically active secondary amine represented by the formula [2] and then by subjecting the secondary amine or its salt to hydrogenolysis. [Chem.Type: GrantFiled: June 8, 2004Date of Patent: July 1, 2008Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Yokusu Kuriyama, Manabu Yasumoto, Masatomi Kanai, Kenjin Inomiya, Takashi Ootsuka, Koji Ueda
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Patent number: 7388094Abstract: 1-?-D-Arabinofuranosyluracil in 3?,5?-hydroxyl-protected form is reacted with a trifluoromethanesulfonylating agent in the presence of an organic base to convert it into a 2?-triflate form, and then it is reacted with a fluorinating agent containing “a salt or complex formed by an organic base and hydrofluoric acid” to produce 2?-deoxy-2?-fluorouridine in 3?,5?-hydroxyl-protected form. A deprotecting agent is further caused to act thereon to obtain 2?-deoxy-2?-fluorouridine. The 2?-deoxy-2?-fluorouridine obtained can efficiently be purified by temporarily converting it into a 3?,5?-diacetyl form, recrystallizing the 3?,5?-diacetyl form, and then deacetylating it. Thus, high-purity 2?-deoxy-2?-fluorouridine can be produced.Type: GrantFiled: April 9, 2004Date of Patent: June 17, 2008Assignee: Central Glass Company LimitedInventors: Akihiro Ishii, Takashi Ootsuka, Masatomi Kanai, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Koji Ueda
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Publication number: 20080125589Abstract: It was found that a fluoro derivative can be produced by reacting a hydroxy derivative with sulfuryl fluoride (SO2F2) in the presence of an organic base or in the presence of an organic base and “a salt or complex comprising an organic base and hydrogen fluoride”. According to the present production process, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in industrial use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, specifically 4-fluoroproline derivatives, 2?-deoxy-2?-fluorouridine derivatives, optically-active ?-fluorocarboxylate derivatives, and the like, even in a large scale.Type: ApplicationFiled: March 17, 2006Publication date: May 29, 2008Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Akihiro Ishii, Takashi Ootsuka, Manabu Yasumoto, Hideyuki Tsuruta, Kenjin Inomiya, Koji Ueda, Kaori Mogi
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Patent number: 7368609Abstract: An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent R2—X, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, each of R1 and R2 independently represents an alkyl group having a carbon atom number of from 1 to 6, Me represents a methyl group, Ar represents a phenyl group or 1- or 2-naphthyl group, * represents a chiral carbon, and X represents a leaving group.Type: GrantFiled: February 12, 2007Date of Patent: May 6, 2008Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Masatomi Kanai, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Takashi Ootsuka, Koji Ueda
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Publication number: 20080103327Abstract: The present invention relates to a process for producing an optically active ?-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active ?-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.Type: ApplicationFiled: August 5, 2005Publication date: May 1, 2008Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Akihiro Ishii, Hideyuki Tsuruta, Takashi Ootsuka, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Koji Ueda
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Patent number: 7268636Abstract: In a voltage controlled oscillator including an amplifier, a feedback circuit and a crystal oscillator, two MOS transistors M1, M2 are connected for use as variable capacity elements for the frequency adjustment of the voltage controlled oscillator. Drains of the MOS transistors M1, M2 are respectively connected to an XT terminal and an XTB terminal of the crystal oscillator. Sources of the MOS transistors M1, M2 are made common and connected to a grounding terminal via a capacitor C3. Gates of the MOS transistors M1, M2 are made common, and an added voltage signal of a temperature compensating signal voltage and an external frequency control signal voltage is applied to the common gate terminals of the MOS transistors to thereby perform the frequency control of the oscillator.Type: GrantFiled: July 14, 2005Date of Patent: September 11, 2007Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hisato Takeuchi, Keigo Shingu, Takashi Ootsuka
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Publication number: 20070191639Abstract: The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII [Chem. 59] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] [Chem. 60] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].Type: ApplicationFiled: February 21, 2005Publication date: August 16, 2007Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Akihiro Ishii, Masatomi Kanai, Yokusu Kuriyama, Manabu Yasumoto, Kenjin Inomiya, Takashi Ootsuka, Katsuhide Suto, Koji Ueda