Abstract: A method for predicting cell membrane permeability of a cyclic peptide enables versatile design of a cyclic peptide with cell membrane permeability. The method includes a first step of acquiring a structure of the cyclic peptide; a second step of calculating a molecular shape factor r which is calculated by Expression (1) after a step of carrying out an ellipsoidal approximation for obtaining each of axis lengths a, b, and c in a case where an axis length in a longest axis direction of a main chain structure is denoted by a, and axis lengths in two other directions which are orthogonal to a and are orthogonal to each other are denoted by b and c in the structure acquired in the first step; and a third step of determining that the cyclic peptide having the molecular shape factor r in a range of 0.4 to 0.6 has cell membrane permeability.

Abstract: A cyclic peptide or a salt thereof having excellent cell membrane permeability, and an MIDMX inhibitor are provided. The cyclic peptide or a salt thereof is represented by Formula (1) in the specification and has characteristics (a) to (c): (a) In a structure of the cyclic peptide, where an axis length in a longest axis direction of a main chain structure is denoted by a, and axis lengths in two other directions which are orthogonal to a and are orthogonal to each other are denoted by b and c, a molecular shape factor r calculated by Formula (2) after a step of carrying out an ellipsoidal approximation for obtaining each of the axis lengths a, b, and c is within a range of 0.4 to 0.6; (b) the main chain structure of the peptide contains a sulfur atom; and (c) the peptide is non-ionic in a physiological environment: r = 2 ? b 2 + c 2 a 2 + b 2 + c 2 + a 2 .

Abstract: A cyclic peptide or a salt thereof having excellent cell membrane permeability and target binding ability to MDMX, and an MDMX inhibitor are provided. The peptide is represented by Formula (1) in the specification and has characteristics (a) to (d): (a) In a structure of the peptide, where an axis length in a longest axis direction of a main chain structure is denoted by a, and axis lengths in two other directions which are orthogonal to a and to each other are denoted by b and c, a molecular shape factor r calculated by Formula (2) after a step of carrying out an ellipsoidal approximation for obtaining each of the axis lengths a, b, and c is within a range of 0.4 to 0.

Abstract: In a wireless communication terminal in a wireless communication system for performing a control not to transmit signals, or to transmit signals with a reduction in a transmission power by a part of radio resources for a downlink signal in a cell provided by a base station, the terminal receives control information in generating a report related to a measurement result of the cell provided by the base station, monitors a state of a radio link with an own cell, and performs measurement on reception of the downlink signal. If an instruction for restricting the measurement to a part of the radio resources is included in the control information from the base station after the radio link failure occurs, the terminal generates and transmits a radio link failure report including the measurement result in the radio resources as instructed when the radio link failure occurs.

Abstract: In a wireless communication terminal in a wireless communication system for performing a control not to transmit signals, or to transmit signals with a reduction in a transmission power by a part of radio resources for a downlink signal in a cell provided by a base station, the terminal receives control information in generating a report related to a measurement result of the cell provided by the base station, monitors a state of a radio link with an own cell, and performs measurement on reception of the downlink signal. If an instruction for restricting the measurement to a part of the radio resources is included in the control information from the base station after the radio link failure occurs, the terminal generates and transmits a radio link failure report including the measurement result in the radio resources as instructed when the radio link failure occurs.

Abstract: A communication terminal is capable of simultaneously communicating through a plurality of carriers by carrier aggregation, and the communication terminal comprises: a quality measurement unit for measuring the reception quality of a radio wave transmitted through a plurality of carriers from a base station of a connected cell to obtain a measured value; a primary carrier storage unit storing information specifying a primary carrier chosen from the plurality of carriers; a comparator for comparing a measured value of the primary carrier measured by the quality measurement unit to a threshold value; and a cell search unit for searching for another cell when the measured value of the primary carrier is less than or equal to the threshold value. Consequently, a search threshold value for carrier aggregation can be appropriately determined to perform a cell search and a quality measurement.

Abstract: Provided is a terminal including a receiver, which, in operation, receives a Channel State Information Reference Signal (CSI-RS) candidate list for CSI-RS configuration information. The CSI-RS candidate list is indicated as Radio Resource Control (RRC) control information for respective terminals. The terminal further includes circuitry, which, in operation, specifies at least one CSI-RS resource information of a measurement target based on the CSI-RS candidate list, and measures a reception power using the specified CSI-RS resource information. The terminal also includes a transmitter, which, in operation, reports the result of the reception power measurement. A reception power measurement method is also provided.

Abstract: The invention relates to methods for improving a scheduling request transmission between a UE and a base station. The transmission of the scheduling request is postponed, by implementing a threshold that the data in the transmission buffer has to reach, before a transmission of the scheduling request is triggered. In one variant, the data in the transmission buffer needs to reach a specific amount, to trigger a scheduling request. The invention refers to further improvements: the PDDCH monitoring time window is delayed after sending a scheduling request; the dedicated scheduling request resources of the PUCCH are prioritized differently such that low-priority scheduling requests are transmitted less often.

Abstract: In a wireless communication terminal in a wireless communication system for performing a control not to transmit signals, or to transmit signals with a reduction in a transmission power by a part of radio resources for a downlink signal in a cell provided by a base station, the terminal receives control information in generating a report related to a measurement result of the cell provided by the base station, monitors a state of a radio link with an own cell, and performs measurement on reception of the downlink signal. If an instruction for restricting the measurement to a part of the radio resources is included in the control information from the base station after the radio link failure occurs, the terminal generates and transmits a radio link failure report including the measurement result in the radio resources as instructed when the radio link failure occurs.

Abstract: A communication terminal is capable of simultaneously communicating through a plurality of carriers by carrier aggregation, and the communication terminal comprises: a quality measurement unit for measuring the reception quality of a radio wave transmitted through a plurality of carriers from a base station of a connected cell to obtain a measured value; a primary carrier storage unit storing information specifying a primary carrier chosen from the plurality of carriers; a comparator for comparing a measured value of the primary carrier measured by the quality measurement unit to a threshold value; and a cell search unit for searching for another cell when the measured value of the primary carrier is less than or equal to the threshold value. Consequently, a search threshold value for carrier aggregation can be appropriately determined to perform a cell search and a quality measurement.

Abstract: Provided is a terminal including a receiver, which, in operation, receives a Channel State Information Reference Signal (CSI-RS) candidate list for CSI-RS configuration information. The CSI-RS candidate list is indicated as Radio Resource Control (RRC) control information for respective terminals. The terminal further includes circuitry, which, in operation, specifies at least one CSI-RS resource information of a measurement target based on the CSI-RS candidate list, and measures a reception power using the specified CSI-RS resource information. The terminal also includes a transmitter, which, in operation, reports the result of the reception power measurement. A reception power measurement method is also provided.

Abstract: The invention relates to methods for improving a scheduling request transmission between a UE and a base station. The transmission of the scheduling request is postponed, by implementing a threshold that the data in the transmission buffer has to reach, before a transmission of the scheduling request is triggered. In one variant, the data in the transmission buffer needs to reach a specific amount, to trigger a scheduling request. The invention refers to further improvements: the PDDCH monitoring time window is delayed after sending a scheduling request; the dedicated scheduling request resources of the PUCCH are prioritized differently such that low-priority scheduling requests are transmitted less often.

Abstract: In a wireless communication terminal in a wireless communication system for performing a control not to transmit signals, or to transmit signals with a reduction in a transmission power by a part of radio resources for a downlink signal in a cell provided by a base station, the terminal receives control information in generating a report related to a measurement result of the cell provided by the base station, monitors a state of a radio link with an own cell, and performs measurement on reception of the downlink signal. If an instruction for restricting the measurement to a part of the radio resources is included in the control information from the base station after the radio link failure occurs, the terminal generates and transmits a radio link failure report including the measurement result in the radio resources as instructed when the radio link failure occurs.

Abstract: An object of the present invention is to provide a reagent for measuring skin sensitization that can measure sensitization to a test substance with high sensitivity using a single type of reagent; a compound; and a method for measuring skin sensitization. According to the present invention, provided are a reagent for measuring skin sensitization including, as a main measuring agent, an organic compound having a mercapto group and a hydrazide structure and having an absorption spectrum in an ultraviolet, visible, or near-infrared region; a compound for use in the reagent for measuring skin sensitization; and a method for measuring skin sensitization using the reagent for measuring skin sensitization.

Abstract: A component supply device including an accommodation body installation unit in which one or more accommodation bodies each accommodating components are installable, the component supply device sequentially operates the one or more accommodation bodies to supply each of the components to a predetermined component supply position. The component supply device comprises a supply state detector which detects a supply state of components in total accommodated in the one or more accommodation bodies installed on the accommodation body installation unit, a determination unit which determines, based on the supply state, a state of the accommodation body installation unit among (i) an installation disabled state, (ii) an installation enabled state, and (iii) an installation required state, and a notifier which notifies a worker of the state of the accommodation body installation unit determined by the determination unit.

Abstract: An integrated circuit includes a plurality of signal inputs, a receiver, calibration circuitry, and input switch circuitry. The receiver includes differential input terminals. The calibration circuitry is configured to calibrate an input offset between the differential input terminals of the receiver in response to the integrated circuit being placed in a calibration mode. The input switch circuitry is configured to switch electrical connections between the plurality of signal inputs and the differential input terminals of the receiver in response to the integrated circuit being placed in a mode different from the calibration mode. The input switch circuitry is further configured to electrically disconnect the plurality of signal inputs from the differential input terminals of the receiver in response to the integrated circuit being placed in the calibration mode.

Abstract: An anti-reflective film laminate includes a first transparent base material, an antireflective layer, and an adhesion layer. The first transparent base material is a plastic film and has a first surface and a second surface which is a surface on a back side with respect to the first surface. The anti-reflective layer includes a hard coat layer, an inorganic multilayer film layer, and an antifouling layer provided in order on the first surface. The adhesion layer is provided on the second surface. The adhesion layer consists of two adhesive layers and a second transparent base material sandwiched between the two adhesive layers and directly adhering to each of the two adhesive layers. A reflectance of the anti-reflective film laminate is 0.8% or less when light with a wavelength of 380 nm to 780 nm is incident. A breaking force of the anti-reflective film laminate is 5.7 N or more.

Abstract: According to an embodiment, there are provided a screening culture medium that enables a convenient and quick examination for the presence of Candida auris, and a screening method. According to at least one embodiment, the screening culture medium contains an enzyme substrate, in which the screening culture medium is used for screening Candida auris based on an ability to degrade the enzyme substrate, the enzyme substrate including raffinose and xylose. According to another embodiment, the screening method uses the screening culture medium.