Patents by Inventor Takashi Tsuruoka
Takashi Tsuruoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4622060Abstract: A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be synergistically enhanced by applying in combination with herbicides selected from Linuron, Monolinuron, Monuron and Diuron each known as herbicides of urea derivative class.Type: GrantFiled: April 1, 1985Date of Patent: November 11, 1986Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4563472Abstract: Triiodoallyl- or iodopropargyl-substituted heterocyclic aromatic compounds which can be prepared by reacting unsubstituted- or substituted nitrogen-containing heterocyclic compounds with corresponding iodine containing alcohol reactive derivatives in the presence of a base in an inert organic solvent. These new heterocyclic aromatic compounds have remarkable antibacterial and antifungal activities and are useful as antibacterial and antifungal agents in medicinal, agricultural and industrial fields.Type: GrantFiled: October 6, 1982Date of Patent: January 7, 1986Assignee: Meiji Seika Kaisha, Ltd.Inventors: Shigeharu Inouye, Taro Niida, Keinosuke Miyauchi, Kuniomi Matsumoto, Eiichi Akita, Masao Koyama, Fumio Kai, Takashi Tsuruoka
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Patent number: 4555404Abstract: Sodium 7.beta.-(2D-2-amino-2-carboxyethylthioacetamido)-7.alpha.-methoxy-3-(1-met hyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate heptahydrate and a method of obtaining it from the corresponding carboxylate.Type: GrantFiled: May 16, 1983Date of Patent: November 26, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Nishihata, Katsuharu Iinuma, Hitoshi Yamada, Fumiya Hirano, Takashi Tsuruoka
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Patent number: 4552584Abstract: A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.Type: GrantFiled: May 18, 1983Date of Patent: November 12, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4552583Abstract: 2-Amino-4-(hydroxy)(methyl)phosphinoylbutyric acid, which earlier nomenclature referred to as 2-amino-4-methylphosphinobutyric acid or its metal salts, or acid-addition salts thereof are used as perennial weeds and brush controlling agents. The L-isomer is twice effective than the racemic acid.Type: GrantFiled: September 21, 1982Date of Patent: November 12, 1985Assignee: Meiji Seika Kaisha Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4495358Abstract: Antibiotic, designated as pyrrolomycin E is described, and which is obtained by cultivating an pyrrolomycin E - producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. SF-2080 (FERM-P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering pyrrolomycin E from the culture which contains also other antibiotic substances (pyrrolomycin A, B, C and D) together with the desired substance.Type: GrantFiled: November 2, 1982Date of Patent: January 22, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Masao Koyama, Takashi Tsuruoka, Norio Ezaki, Keinosuke Miyauchi, Shigeharu Inouye
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Patent number: 4469643Abstract: Disclosed are compounds having the following general formula: ##STR1## wherein n is an integer of 1 or 2; R.sup.1 is an amino group when n is 2, or an amino group or a hydroxyl group when n is 1; and R.sup.2 is a hydroxyl group when n is 1, or a hydroxyl group or a group of the formula ##STR2## when n is 2; and microbiological process for producing the same. The compounds are useful as precursors for raising the production rate of SF-1293 substance. Some of the compounds are also useful as intermediates for synthesis of 2-amino-4-(hydroxy)(methyl)phosphinoylbutyric acid and the SF-1293 substance.Type: GrantFiled: November 10, 1983Date of Patent: September 4, 1984Assignee: Meiji Seika Kaisha Ltd.Inventors: Takashi Tsuruoka, Satoshi Imai, Atsuyuki Satoh, Tetsuro Watanabe, Koji Watanabe, Shigeharu Inouye, Taro Niida
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Patent number: 4466913Abstract: 2-Amino-4-(hydroxy)phosphinoylbutyryl-L-alanyl-L-alanine.Type: GrantFiled: June 14, 1982Date of Patent: August 21, 1984Assignee: Maiji Seika Kaisha Ltd.Inventors: Takashi Tsuruoka, Satoshi Imai, Atsuyuki Satoh, Tetsuro Watanabe, Koji Watanabe, Shigeharu Inouye, Taro Niida
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Patent number: 4455163Abstract: A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.Type: GrantFiled: May 15, 1981Date of Patent: June 19, 1984Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4448601Abstract: A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.Type: GrantFiled: December 23, 1981Date of Patent: May 15, 1984Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4382812Abstract: 2-Amino-4-(hydroxy) (methyl)phosphinoylbutyric acid, which earlier nomenclature referred to as 2-amino-4-methylphosphinobutyric acid or its metal salts, or acid-addition salts thereof are used as perennial weeds and brush controlling agents. The L-isomer is twice effective than the racemic acid.Type: GrantFiled: August 20, 1979Date of Patent: May 10, 1983Assignee: Meiji Seika Kaisha Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4325951Abstract: New antibacterial 1-oxadethiacephalosporin derivatives of the general formula ##STR1## wherein R is a heterocyclic group or a group --S--Het where Het denotes a heterocyclic group, Y is a hydrogen atom or a methoxy group; x and y are each an integer of 1 to 3 is produced by a process comprising condensing a 1-oxacephem compound of the formula ##STR2## wherein R, Y, y are as defined above; R' is a hydrogen atom or a carboxyl-protecting group; and Z is a halo group, with a sulfur-containing amino acid of the formula ##STR3## wherein x is as defined above, in a solvent and removing, if necessary, the residual protective group from the resultant condensation product. The new 1-oxadethiacephalosporin derivatives and the pharmaceutically acceptable salts and esters thereof exhibit high and broad "in vitro" and "in vivo" antibacterial activity, particularly against .beta.-lactamase-producing strains of gram-negative bacteria.Type: GrantFiled: October 24, 1980Date of Patent: April 20, 1982Assignee: Meiji Seika Kaisha, Ltd.Inventors: Shigeharu Inouye, Takashi Tsuruoka, Katsuyoshi Iwamatsu
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Patent number: 4324891Abstract: A new, efficient process is provided for the production of 7.beta.-[(2D-2-amino-2-carboxy)-ethylthio-acetamido]-7.alpha.-methoxy-3-[( 1-methyl-1H-tetrazole-5-yl) thiomethyl]-3-cephem-4-carboxylic acid useful as new antibacterial agent. This process is economic in using as the starting material the inexpensive, corresponding cephem compound containing no 7.alpha.-methoxy group on the cephem nucleus and comprises 7.alpha.-methoxylation of a protected derivative of the starting cephem compound with t-butyl hypochlorite and lithium methoxide, followed by inactivation of the excessive methoxylation reagents with a trialkyl phosphite and acetic acid to prevent undesired side-reactions such as oxidation of the alkylthioacetyl group of the product, and further by conventional removal of the protecting groups.Type: GrantFiled: August 15, 1980Date of Patent: April 13, 1982Assignee: Meiji Seika Kaisha, Ltd.Inventors: Katsuyoshi Iwamatsu, Takashi Tsuruoka, Kazuko Mizutani, Katsumi Kawaharajyo, Tadahiro Watanabe, Shigeharu Inouye
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Patent number: 4309208Abstract: A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.Type: GrantFiled: November 13, 1978Date of Patent: January 5, 1982Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4302580Abstract: A chemotherapeutic, antibacterial agent, 7.beta.-[(2D-2-amino-2-carboxy)ethylthioacetamido]-7.alpha.-methoxy-3-[(1- methyl-1H-tetrazole-5-yl)thiomethyl]-3-cephem-4-carboxylic acid is produced economically and efficiently starting from cephamycin A and/or B by a "new route" process comprising the consecutive steps of reaction of cephamycin with 5-mercapto-1-methyl-1H-tetrazole; protection of the terminal amino group thereof by acylation; protection of the two carboxyl groups thereof by esterification; replacement of the acyl group initially having attached to the 7-amino group by a halogenoacetyl group; deprotection of the blocked 4-carboxyl group; and condensation of D-cysteine with the halogenoacetyl group attaching to the 7-amino group.Type: GrantFiled: September 9, 1980Date of Patent: November 24, 1981Assignee: Meiji Seika Kaisha, Ltd.Inventors: Katsuyoshi Iwamatsu, Jiro Itoh, Shoji Omoto, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 4265654Abstract: 2-Amino-4-methylphosphinobutyric acid or its metal salts, or acid-addition salts thereof are used as perennial weeds and brush controlling agents. The L-isomer is twice effective than the racemic acid. The perennial weeds and brush controlling effect may be obtained by foliar application over a prolonged period.Type: GrantFiled: December 20, 1978Date of Patent: May 5, 1981Assignee: Meiji Seika Kaisha Ltd.Inventors: Tetsuo Takematsu, Makoto Konnai, Kunitaka Tachibana, Takashi Tsuruoka, Shigeharu Inouye, Tetsuro Watanabe
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Patent number: 4264532Abstract: PCT No. PCT/JP78/00058 Sec. 371 Date June 15, 1979 Sec. 102(e) Date June 15, 1979 PCT Field Dec. 18, 1978 PCT Pub. No. WO79/00405 PCT Pub. Date July 12, 1979This invention relates to a novel process for preparing D,L-2-amino-4-methylphosphinobutyric acid having herbicidal and antifungicidal activities which comprises subjecting acrolein to reaction with a dialkyl phosphonite to synthesize an acetal of an ester of 3-oxopropylmethylphosphinic acid; treating the thus obtained compound with an acid for deacetalization to obtain an ester of 3-oxopropylmethylphosphinic acid and then applying the Strecker's process used for amino synthesis to the thus obtained ester.Type: GrantFiled: June 15, 1979Date of Patent: April 28, 1981Inventors: Takashi Tsuruoka, Akira Suzuki, Kunitaka Tachibana, Kazuko Mizutani, Yasuharu Sekizawa, Shigeharu Inouye, Tetsuo Takematsu
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Patent number: 4258184Abstract: Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.Type: GrantFiled: March 13, 1979Date of Patent: March 24, 1981Assignee: Meiji Seika Kaisha Ltd.Inventors: Fumio Kai, Takashi Tsuruoka, Osamu Makabe, Shigeharu Inouye, Hitoshi Ikeda, Yuzo Kazuno, Shokichi Nakajima, Shigeo Seki, Taro Niida
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Patent number: 4242327Abstract: New antibiotic, SF-2052 substance is produced by cultivating a microorganism, Dactylosporangium matsuzakiense SF-2052 now deposited under FERM-P 4670 or ATCC No. 31570 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the culture broth by conventional method and is useful as antibacterial agent.Type: GrantFiled: October 31, 1979Date of Patent: December 30, 1980Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazunori Ohba, Takashi Shomura, Michio Kojima, Shoji Omoto, Takashi Tsuruoka, Shigeharu Inoue
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Patent number: 4229448Abstract: 5-Substituted picolinic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R.sub.3 and R.sub.4, when taken together, represent a polymethylene chain; and R.sub.Type: GrantFiled: March 23, 1979Date of Patent: October 21, 1980Assignee: Meuji Seika Kaisha Ltd.Inventors: Yasuharu Sekizawa, Takashi Tsuruoka, Mitsugu Hachisu, Masaji Sezaki, Masashi Miyamoto, Uichi Shibata, Kazuko Mizutani, Shigeharu Inouye, Takemi Koeda, Keizo Shimomura, Taro Niida