Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing emetine or a salt thereof.

Abstract: Provided is a hybrid construction machine capable of appropriate control of engine speed based on a total load torque, reduction in energy loss due to the power for auxiliary devices and efficient operation of the engine and the generator motor, including a hydraulic pump, a generator motor, an engine, and a control device. The control device includes a total load torque determination section determining a total load torque, the sum of load torques for the hydraulic pump and the generator motor, and an engine speed control section controlling the engine speed based on the total load torque. The engine speed control section performs a regulation control of increasing the engine speed as the total load torque decreases under a high load torque condition and performs an isochronous control of maintaining the engine speed at a constant target speed N2 under a low load torque condition.

Abstract: The present disclosure can reduce a force required for the attachment of a sealing member to a flange of a body of an automobile, thereby facilitating the attachment, and can reduce the separation of the attached sealing member from the flange to ensure good seal. An outer foam 25 which comes into contact with an exterior face of a flange 110 facing the outside of a cabin is provided for an inner face of an outer wall 20. A flexible seal lip 21a is provided for an inner face of an inner wall 21. A bottom foam 26 bulges from an inner face of a bottom wall 22. A distance between the outer and bottom foams 25 and 26 in a width direction of the automobile is smaller than a thickness of a thinnest portion of the flange 110.

Abstract: A rotation drive apparatus for rotating an upper rotary body of a construction machine, the rotation drive apparatus eliminating, while achieving a fundamental goal of stopping a rotation when an emergency stop operation is performed, wasteful stopping by a parking brake. The apparatus includes: an emergency stop switch; a rotation control section which performs control to stop a rotating motor when the emergency stop operation is applied to the emergency stop switch; and a timer which activates the parking brake when a set period of time has elapsed after the emergency stop operation is performed. Preferably, the rotation control section detects a failure of an inverter and causes the parking brake to perform a braking operation before the elapse of the set period of time when the failure is detected.

Abstract: To provide a working machine including a lower travelling body and an upper slewing body disposed in a slewable manner with respect to the lower travelling body, the working machine being capable of more reliably preventing the upper slewing body from coming into contact with an obstacle existing around the working machine. The working machine includes a detection device, a position identification device, and a movement control device. The position identification device includes a calculation section, a conversion section, and an identification section. The movement control device controls the movement of the upper slewing body in such a way as to prevent the upper slewing body from coming into contact with the obstacle based on the position of the obstacle relative to the virtual boundary surface, the position being identified by the identification section.

Abstract: A brake control unit operates a mechanical brake when a slewing operation amount detected by a slewing operation amount detection unit indicates slewing stop and when a slewing speed detected by a slewing speed detection unit is equal to or lower than a predetermined speed. A time measurement unit measures a brake operation time period during which a brake operation detection value detected by a brake operation detection unit exceeds a predetermined threshold. When the mechanical brake is operated and when the brake operation time period measured by the time measurement unit exceeds a predetermined reference time period, a slewing control unit stops outputting a slewing command.

Abstract: A first warming-up control unit calculates warming-up time charging power from a power storage SOC and power storage temperature and causes a generator motor to perform power generation operation thereby charging a power storage unit on the basis of the calculated warming-up time charging power. A second warming-up control unit applies, during the power generation operation, a hydraulic load to a hydraulic pump by a hydraulic load unit and performs horsepower control of the hydraulic pump using a value obtained by subtracting the warming-up time charging power from preset warming-up time pump horsepower.

Abstract: A hybrid construction machine detects the voltage of each cell that forms a battery, calculates a difference voltage between the detected voltage and a predetermined upper-limit working voltage, selects the lower one of the calculated difference voltage and a stored difference voltage, corrects an upper-limit working charging rate to decrease as the selected difference voltage decreases, and controls charging of the battery, based on the corrected upper-limit working charging rate.

Abstract: A rotation drive apparatus for rotating an upper rotary body of a construction machine, the rotation drive apparatus eliminating, while achieving a fundamental goal of stopping a rotation when an emergency stop operation is performed, wasteful stopping by a parking brake. The apparatus includes: an emergency stop switch; a rotation control section which performs control to stop a rotating motor when the emergency stop operation is applied to the emergency stop switch; and a timer which activates the parking brake when a set period of time has elapsed after the emergency stop operation is performed. Preferably, the rotation control section detects a failure of an inverter and causes the parking brake to perform a braking operation before the elapse of the set period of time when the failure is detected.

Abstract: A brake control unit operates a mechanical brake when a slewing operation amount detected by a slewing operation amount detection unit indicates slewing stop and when a slewing speed detected by a slewing speed detection unit is equal to or lower than a predetermined speed. A time measurement unit measures a brake operation time period during which a brake operation detection value detected by a brake operation detection unit exceeds a predetermined threshold. When the mechanical brake is operated and when the brake operation time period measured by the time measurement unit exceeds a predetermined reference time period, a slewing control unit stops outputting a slewing command.

Abstract: Provided is a hybrid construction machine capable of appropriate control of engine speed based on a total load torque, reduction in energy loss due to the power for auxiliary devices and efficient operation of the engine and the generator motor, including a hydraulic pump, a generator motor, an engine, and a control device. The control device includes a total load torque determination section determining a total load torque, the sum of load torques for the hydraulic pump and the generator motor, and an engine speed control section controlling the engine speed based on the total load torque. The engine speed control section performs a regulation control of increasing the engine speed as the total load torque decreases under a high load torque condition and performs an isochronous control of maintaining the engine speed at a constant target speed N2 under a low load torque condition.

Abstract: A first warming-up control unit calculates warming-up time charging power from a power storage SOC and power storage temperature and causes a generator motor to perform power generation operation thereby charging a power storage unit on the basis of the calculated warming-up time charging power. A second warming-up control unit applies, during the power generation operation, a hydraulic load to a hydraulic pump by a hydraulic load unit and performs horsepower control of the hydraulic pump using a value obtained by subtracting the warming-up time charging power from preset warming-up time pump horsepower.

Abstract: The present charging rate of a battery is accurately calculated. The calculation mode of the present charging rate is switched to a current integration mode during operation of a generator motor while the mode is switched to a voltage reference mode at a predetermined switchover timing. In the current integration mode, charge current of the battery is integrated and added to the initial charging rate and an integrated discharge current value is subtracted from the initial charging rate of the battery to calculate the present charging rate. In the voltage reference mode, the present charging rate is calculated based on a predetermined map and detected voltage of the battery. After calculation of the present charging rate according to the voltage reference mode, the calculation mode is restored from the voltage reference mode to the current integration mode and the suspension of operating the generator motor is cancelled.

Abstract: A hybrid construction machine detects the voltage of each cell that forms a battery, calculates a difference voltage between the detected voltage and a predetermined upper-limit working voltage, selects the lower one of the calculated difference voltage and a stored difference voltage, corrects an upper-limit working charging rate to decrease as the selected difference voltage decreases, and controls charging of the battery, based on the corrected upper-limit working charging rate.

Abstract: Provided is an electric power control apparatus capable of suppressing charge/discharge with respect to an electrical storage device under an anomalous condition. The electric power control apparatus includes an electrical storage device including electrical storage modules, a module-temperature detection section, a temperature-condition judgment section, an adopted-module-temperature selection section, and a charge/discharge-electric-power-upper-limit setting section. The temperature-condition judgment section makes a judgment on a temperature condition of the electrical storage device based on a temperature detected by an electrical-storage-device temperature detection section.

Abstract: A charge and discharge control unit (41) sets an upper-limit charge and discharge electric power as an upper limit of electric power during charging and discharging of a electric storage device (11) based on temperature of the electric storage device (11) measured by a temperature measuring unit (21) and a state of charge of the electric storage device (11) specified by a charge state specifying unit (23). In the case where the operation state determined by an operation state determining unit (35) is a low-limit operation state, the charge and discharge control unit (41) sets the upper-limit charge and discharge electric power to be larger than that in the case where the operation state determined by the operation state determining unit (35) is a high-limit operation state.

Abstract: Provided is an electric power control apparatus capable of suppressing charge/discharge with respect to an electrical storage device under an anomalous condition. The electric power control apparatus includes an electrical storage device including electrical storage modules, a module-temperature detection section, a temperature-condition judgment section, an adopted-module-temperature selection section, and a charge/discharge-electric-power-upper-limit setting section. The temperature-condition judgment section makes a judgment on a temperature condition of the electrical storage device based on a temperature detected by an electrical-storage-device temperature detection section.

Abstract: Disclosed is a hybrid construction machine including: an engine, a generator-motor, a hydraulic pump, an electric storage device, a power control device which controls electric power between the generator-motor and the electric storage device, a temperature detector which determines a temperature of the electric storage device, an unload valve provided between a discharge port of the hydraulic pump and a tank, an unload-valve control device, and a relief valve. The power control device controls an electric power to be supplied from the electric storage device to the generator-motor, under abnormal circumstances where the temperature of the electric storage device is low, to a power obtained by adding an additional discharge power to a power to be supplied under normal circumstances. The unload-valve control device closes the unload valve, under abnormal circumstances. The relief valve controls the discharge pressure of the hydraulic pump to the set pressure, under abnormal circumstances.