Abstract: A wire travelling device that travels a stretched wire between a wire feed roller and a wire collection roller includes a wire-feed-roller circumferential-speed calculation unit and a wire-collection roller circumferential-speed calculation unit that calculate each circumferential speed of the wire feed roller and the wire collection roller, a circumferential-speed-difference holding unit that calculates a difference between the circumferential speed of the wire feed roller and the circumferential speed of the wire collection roller as a circumferential speed difference and holds therein the calculated circumferential speed difference, and a wire-feed-roller speed control unit and a wire-collection roller speed control unit that control the wire feed roller and the wire collection roller, in changing a traveling speed of the wire, by a wire-feed-roller speed instruction value and a wire-collection roller speed instruction value generated so that the circumferential speed difference before changing the traveli

Abstract: The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof: The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.

Abstract: In order to detect a wire breakage as soon as possible, the wire electrical discharge machining apparatus includes a speed fluctuation compensator that generates a speed fluctuation suppression command that is a speed compensation value that suppresses fluctuation of the rotational speed of the tension motor on the basis of the rotational speed of the tension motor and a breakage detecting device that detects a breakage of the wire electrode on the basis of a comparison of a preset breakage detection threshold and a speed fluctuation suppression command output from the speed fluctuation compensator.

Abstract: An electric discharge machining apparatus of the present invention includes a power supply, an electrode gap configured so as to be formed by an electrode and a workpiece, and an earth floating-capacitance current-suppressing coil configured to be inserted between the power supply and the electrode gap. Accordingly, the impedance in the charging path from the power supply to an interelectrode capacitance (an interelectrode parallel capacitor and an interelectrode parallel floating capacitance) can be decreased, and the impedance in the charging path to an earth floating capacitance can be increased, thereby enabling the electric current from the earth floating capacitance during discharge machining to be suppressed.

Abstract: The present invention includes drive units 7a and 7b that change a relative position between a wire electrode 12 and a workpiece 14 by moving a position of wire guide 8a and 8b, drive control units 6a and 6b that drive the drive units 7a and 7b based on a machining shape on the workpiece 14, respectively, a correction-amount storage unit 3 that previously stores therein a position correction amount for the wire electrode 12 corresponding to a machining condition, a correction-amount reading unit 4 that reads the position correction amount corresponding to the machining condition from the correction-amount storage unit 3, and a wire-position correction unit 5 that causes the drive control units 6a and 6b to correct a relative distance between the wire electrode 12 and the workpiece 14 based on the read position correction amount.

Abstract: The present invention includes a post-cooling temperature sensor that measures a temperature of the machining fluid immediately after being cooled by a cooling device as a post-cooling fluid temperature, and an intra-tank temperature sensor that measures a temperature of the machining fluid in a work tank as an intra-tank fluid temperature, for a cooling control device that controls a fluid temperature of the machining fluid in a wire electric discharge machining apparatus, and the cooling control device has a first temperature-feedback control unit that feeds back the post-cooling fluid temperature into a cooling instruction value as an instruction value for the cooling device, and a second temperature-feedback control unit adjusts the cooling instruction value by feeding back the intra-tank fluid temperature to cause the intra-tank fluid temperature to follow a target temperature.

Abstract: An electrical discharge machine feeds an electrode wire received within a guide tube to a process region of a machined article. The electrical discharge machine includes a cylindrical hollow driving shaft arranged in a vertical direction, which has a space for receiving the guide tube with the electrode wire along a vertical central axis. A head assembly includes a first holding member for holding the guide tube, and a second holding member for holding the electrode wire extending from a bottom opening of the guide tube. The head assembly is detachably coupled with a bottom portion of the driving shaft. Therefore, the electrode wire can be replaced by replacing the head assembly.

Abstract: A bridge circuit of an embodiment includes: a command transfer portion which is configured by wired logic into which a host controller capable of sending a command that corresponds to each of a plurality of devices inputs the command, and which is configured to transfer the inputted command to the plurality of devices; a command analysis portion which is configured by wired logic, and which is configured to analyze the command from the host controller; and a response reply portion which is configured by wired logic, and which is capable of reading out a response based on an analysis result of the command analysis portion from a register that holds a response corresponding to the command and sending the response to the host controller.

Abstract: A drive unit supplies to an auxiliary information generating section a first event notice related to reproducing operation and a second event notice indicating reproducing position information, regarding content recorded on a recording medium. The auxiliary information generating section generates auxiliary information based on the first and second event notices, for storage in an information storage section. A comparison/computation section makes a comparison or a computation using the reproducing position information indicated by the auxiliary information and reproducing position information indicated by a later-supplied second event notice. A command issuing section issues a command for controlling reproduction of the content based on a result of the comparison or the computation. As a result, a reproducing operation differing from an operation according to a predetermined command can be performed.

Abstract: A wire electric discharge machining apparatus according to embodiments includes a wire electrode, a wire supplying unit that supplies the wire electrode, a collecting motor that collects the wire electrode at a predetermined speed, a tension motor that controls a tension of the wire electrode between the wire supplying unit and the collecting motor, a speed calculating unit that calculates a traveling speed of the wire electrode at a predetermined time interval, a speed storing unit that stores the traveling speed calculated by the speed calculating unit, a differential speed calculating unit that calculates a differential speed between a current traveling speed output from the speed calculating unit and a past traveling speed stored in the speed storing unit, and a breakage detecting unit that detects breakage of the wire electrode by comparing the differential speed with a predetermined threshold.

Abstract: The automatic wire-threading device includes a wire feed motor that drives a wire feed roller in a feeding direction, a wire-feed-motor control unit that outputs a feeding-direction rotation-speed reference to the wire feed motor at a time of a threading operation of a wire electrode and that reduces torque in a feeding direction when a detected rotation speed of the wire feed roller is larger than the feeding-direction rotation-speed reference, a wire collecting motor that drives a wire collecting roller in a collecting direction, and a wire-collecting-motor control unit that outputs a predetermined wire-collecting-roller speed reference to the wire collecting motor to collect a wire. The wire-feed-motor control unit limits torque so that an absolute value of motor torque in a winding-back direction of a wire feed roller is smaller than an absolute value of motor torque in a feeding direction.

Abstract: An antitumor agent for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound or pharmaceutically acceptable salt thereof represented by Formula (II) exhibits an excellent antitumor effect compared to cases where these are individually used, and exhibits antitumor effects against various cancer types: wherein R1 is azetidinyl and the like, R2 to R5 is a hydrogen atom or a halogen atom, R6 is C3-8 cycloalkyl and the like, R7 is a hydrogen atom and the like, and R8 is a halogen atom and the like.

Abstract: An electrical discharge machining apparatus includes a machining electrode that is one wire and includes a plurality of opposing sections with respect to a workpiece by being wound around a plurality of guide rollers, driving units that change a relative distance between the workpiece and the opposing sections, and a plurality of pulse generating units that apply electrical discharge machining pulses between the workpiece and the opposing sections, respectively, in which the pulse generating units are controlled such that application start times of electrical discharge machining pulses for adjacent opposing sections do not coincide with each other.

Abstract: A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH?, nitrogen.

Abstract: The present invention provides a radiolabeled ligand which is highly selective and potent for glutamate transporters and is usable in specifically detecting the glutamate transporter. Specifically, the present invention provides a 3-[3-(benzoylamido)benzyloxy]aspartic acid having a radioactive substituent on the benzoyl group which is represented by the following formula (1), or an ester or salt thereof: wherein X represents a substituent containing a radioactive atom(s) which is selected from a straight or branched lower aliphatic alkyl group, a hydroxyl group, a straight or branched lower aliphatic alkoxy group, an amino group, a straight or branched lower aliphatic acylamido group, a halogen atom and a straight or branched lower aliphatic haloalkyl group; and R1 and R2 each represents a hydrogen atom, a straight or branched lower aliphatic alkyl group or an acetoxymethyl group.

Abstract: A method of treating esophageal cancer, containing the step of administering to a patient suffering from esophageal cancer, a compound or a salt thereof, wherein the compound is: N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, N-[4-({2-[(azetidin-1-ylcarbonyl)amino]pyridin-4-yl}oxy)-2-fluorophenyl]-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, N-{2,5-difluoro-4-[(2-{[(3-hydroxyazetidin-1-yl)carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, N-(2,5-difluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, N-(2,5-difluoro-4-{[2-({[methyl(1-methyl-piperidin-4-yl)amino]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide, or N-(2,5-difluoro-4-{[2-({[3-(hydroxymethyl)azetidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)

Abstract: A control node includes: a monitoring packet transmission section for transmitting a monitoring packet; a monitoring packet reception section for receiving a monitoring packet; an adjustment section for selecting a redundant node from a non-control nodes; a packet generation section for generating a setup packet for specifying the redundant node out of the non-control nodes in accordance with information about the redundant node selected by the adjustment section; and a packet transmission section for transmitting the setup packet to the non-control node. The non-control node includes a control section that acquires information about the traffic upon receiving the monitoring packet, transmits a monitoring packet after acquisition of the traffic, and specifies the non-control node as the redundant node based on information about the redundant node contained in the setup packet upon receiving the setup packet.

Abstract: The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof: The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.

Abstract: A compound represented by the following formula, a salt thereof or a hydrate of the foregoing is useful as a pharmaceutical composition for treating esophageal cancer treating esophageal cancer. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH?, nitrogen or the like.

Abstract: An electric discharge machining apparatus includes a guide electrode that is tubular and receives a small-diameter wire electrode for electric discharge machining. The small-diameter wire electrode can freely slide within the guide electrode. A guide electrode holder holds the guide electrode at a specified position. Pressurized fluid is supplied into the guide electrode to feed the small-diameter wire electrode from the guide electrode. A small-diameter wire electrode holder automatically releases and grasps the small-diameter wire electrode in response to starting and stopping of the pressurized fluid supply, respectively.