Abstract: A processor of an image processing device acquires a medical image including a lesion region, and causes a determiner to perform a determination process of determining a type of a lesion on the basis of the medical image. A first determination process is a process of determining whether the type belongs to a first group including a first type classified as a first category and a second type classified as a second category or a second group including a third type classified as the second category. A second determination process is a process of determining whether the type is the first type or the second type. The processor outputs a first signal for specifying whether the type is classified as the first category or the second category on the basis of a determination result of the first determination process and a determination result of the second determination process.

Abstract: Provided is a design method for dividing primer pairs into reaction containers, the design method showing an optimum division example. The design method for dividing primer pairs into reaction containers has a design step of, for a plurality of target nucleic acids, designing a plurality of primer pairs each composed of two types of primers, an evaluation step of evaluating non-specific amplification inducibility between the primer pairs, and an assignment step of performing an assignment to the reaction containers, based on the non-specific amplification inducibility, such that primer pairs having the non-specific amplification inducibility are not present in the same reaction container.

Abstract: An acetoacetyl group-containing polyvinyl alcohol resin having little variation in acetoacetyl group content depending on particle size range. The acetoacetyl group-containing polyvinyl alcohol resin is a particulate acetoacetyl group-containing polyvinyl alcohol resin having an acetoacetyl group content distribution such that a ratio between the highest and the lowest acetoacetyl group content determined for a particle diameter range of less than 105 ?m, a particle diameter range of not less than 105 ?m and less than 177 ?m, a particle diameter range of not less than 177 ?m and less than 600 ?m, and a particle diameter range of not less than 600 ?m ((highest acetoacetyl group content)/(lowest acetoacetyl group content)) is less than 1.2.

Abstract: There are provided a learning apparatus, a learning method, an image processing apparatus, an endoscope system, and a program that enable generation of training data on the basis of output data from a learning model for which learning is performed by using normality data. A first learning model (500) is generated by performing first learning using normality data (502) as learning data or by performing first learning using as learning data, normality mask data (504) that is generated by making a part of normality data be lost, and second training data to be applied to a second learning model that identifies identification target data is generated by using output data output from the first learning model in response to input of abnormality data to the first learning model.

Abstract: An image acquisition unit sequentially acquires a medical image. A recognition processing unit applies a recognition process to the medical image. A recognition result display determination unit determines to display or not display the result of the recognition process on a display according to blur in the medical image. A display control unit controls the display of the recognition process according to the determination by the recognition result display determination unit.

Abstract: An endoscope system sequentially acquires a plurality of endoscopic images by continuously imaging an observation target. A recognition processing unit detects, from the acquired endoscopic images, regions including a lesion portion as regions-of-interest. A recognition result correction unit corrects a position of the region-of-interest of the specific image by using a position of the region-of-interest of a previous image acquired before the specific image and a position of the region-of-interest of a subsequent image acquired after the specific image.

Abstract: Provided are a learning device, a depth information acquisition device, an endoscope system, a learning method, and a program capable of efficiently acquiring a learning data set used for machine learning to perform depth estimation, and capable of implementing a highly accurate depth estimation for an actually imaged endoscope image.

Abstract: In a learning device, method, and program for a discriminator, and a discriminator, it is possible to enable accurate learning of a discriminator that discriminates a state of an object to be observed, such as a cell. An image acquisition unit acquires a first image including an influence of a meniscus and a second image with the influence of the meniscus eliminated for the same object to be observed. Next, a training data generation unit generates training data for learning a discriminator based on the second image. Then, a learning unit learns the discriminator based on the first image and the training data.

Abstract: Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region for determining the genetic condition, from regions on a human genome; a step of isolating a single cell from a maternal blood sample; a step of extracting genomic DNA from the single cell; a step of performing PCR amplification on the objective region using a primer set designed so as to perform the PCR amplification on the objective region using genomic DNA extracted from the single cell as a template; and a DNA sequencing step of decoding a DNA base sequence of a PCR amplification product of the objective region, in which the primer set designed so as to perform the PCR amplification on the objective region is designed through a method for designing a primer set used for the polymerase chain reaction, the method for designing a primer set including a first stage selection step based on a local alignment score and a second stage selection step based o

Abstract: A method for designing a primer supplied to a PCR reaction includes a primer designing step of defining a 5?-end-side base sequence of the primer so as to include a base sequence or its complementary base sequence, the base sequence enabling identification of, among thermal cycles in the PCR reaction, a synthesis cycle of a DNA molecule in an amplification product obtained by the PCR reaction performed with the primer, the identification being based on base-sequence data obtained by sequencing the amplification product.

Abstract: In a learning device, method, and program for a discriminator, and a discriminator, it is possible to enable accurate learning of a discriminator that discriminates a state of an object to be observed, such as a cell. An image acquisition unit acquires a first image including an influence of a meniscus and a second image with the influence of the meniscus eliminated for the same object to be observed. Next, a training data generation unit generates training data for learning a discriminator based on the second image. Then, a learning unit learns the discriminator based on the first image and the training data.

Abstract: Provided is a method for obtaining base sequence information of a single cell derived from a vertebrate, by which PCR amplification of an objective region can be performed uniformly and accurately.

Abstract: Provided are a method for discriminating an origin of human genomic DNA of 100 pg or less by uniformly amplifying human genomic DNA of 100 pg or less, a method for identifying an individual, and a method for analyzing a level of engraftment of hematopoietic stem cells.

Abstract: There is provided a method for designing primers for multiplex PCR, in which, as a result of designing primers in candidate amplification regions for which priorities are set, if the number of candidate amplification regions in which primers are successfully designed does not reach a desired value, primers can be redesigned while a broad feature of previously set priorities is maintained.

Abstract: Provided are a method for determining the number of loci required, and a method for determining the number of SNPs loci required.

Abstract: There is provided a method for designing primers for multiplex PCR, for assigning priorities to candidate amplification regions on same chromosomal DNA and designing primers for PCR amplifying the candidate amplification regions according to the priorities, the method having a feature in a method for assigning priorities.

Abstract: There is provided a method for designing primers for multiplex PCR, in which amplification variations for each region of interest can be suppressed in a plurality of single cells by repeatedly attempting multiplex PCR for a small number of regions of interest, separating the regions of interest into a group of regions of interest for which the coefficient of variation for the number of sequence reads is greater than or equal to a threshold value and a group of regions of interest for which the coefficient of variation for the number of sequence reads is less than the threshold value, generating a histogram for each group, each histogram having a horizontal axis representing the average Tm value of a pair of primers used to PCR amplify each region of interest and a vertical axis representing the number of regions of interest, calculating the lower limit value and the upper limit value of a Tm value range for primer design, setting the obtained Tm value range, and designing primers.

Abstract: The cell imaging control device includes a cell detection unit 22 that acquires a cell image by imaging transmitted light or reflected light of undyed cells and detects the cells or structures in the cells in the cell image and an autofocus control unit 24 that calculates an autofocus evaluation value based on image information of the cells or the structures detected by the cell detection unit 22 and outputs an autofocus control signal based on the autofocus evaluation value to an imaging device for capturing the cell image, which is an imaging device having an autofocus function.

Abstract: Provided is a chromosome number determination method including: a step of performing multiplex PCR for simultaneously amplifying a plurality of loci on chromosomes using genomic DNA extracted from a single cell or a small number of cells as templates, in which the multiplex PCR includes a plurality of thermal cycles including thermal denaturation, annealing, and elongation, annealing time is longer than or equal to 90 seconds and shorter than 1,500 seconds in at least one of the plurality of thermal cycles, a plurality of primer sets used in the multiplex PCR are designed through a method for designing primer sets used in a polymerase chain reaction including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.

Abstract: Provided is a chromosome number determination method of chromosomes of interest, including: a step of performing multiplex PCR for simultaneously amplifying a plurality of loci on the chromosomes using genomic DNA extracted from a single cell or a small number of cells as templates, in which the number of loci on the chromosomes of interest is greater than or equal to 80 per chromosome, and a plurality of primer sets used in the multiplex PCR are designed through a method for designing primer sets used in a polymerase chain reaction including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.