Abstract: A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result.

Abstract: Provided is a method for determining whether cells or cell groups that have a possibility of being derived from a plurality of persons are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, the method including: a step of acquiring genotypic data for gene polymorphism sites of the cells or cell groups and weighting the data with a preset weight distribution, to acquire weighted genotypic data; and a step of using the weighted genotypic data to determine whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, in which the preset weight distribution is set by mapping of a measured apparent genotype and a true genotype with respect to the gene polymorphism sites, and the method being capable of determining, with high accuracy, whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a bloo

Abstract: A method for designing a primer supplied to a PCR reaction includes a primer designing step of defining a 5?-end-side base sequence of the primer so as to include a base sequence or its complementary base sequence, the base sequence enabling identification of, among thermal cycles in the PCR reaction, a synthesis cycle of a DNA molecule in an amplification product obtained by the PCR reaction performed with the primer, the identification being based on base-sequence data obtained by sequencing the amplification product.

Abstract: There are included a colony evaluation unit 31 that acquires an evaluation result of the cell colony in a cell image obtained by imaging the cell colony, a divided region setting unit 32 that sets a plurality of divided regions by dividing the region of the cell colony according to the evaluation result, a display control unit 34 that displays each of the plurality of divided regions, and a region deformation unit 33 that deforms the divided regions according to a change in the form of the cell colony due to an operation on the cell colony. The display control unit 34 changes a display of the divided regions before the change in form of the cell colony to a display of the divided regions after the deformation.

Abstract: Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region for determining the genetic condition, from regions on a human genome; a step of isolating a single cell from a maternal blood sample; a step of extracting genomic DNA from the single cell; a step of performing PCR amplification on the objective region using a primer set designed so as to perform the PCR amplification on the objective region using genomic DNA extracted from the single cell as a template; and a DNA sequencing step of decoding a DNA base sequence of a PCR amplification product of the objective region, in which the primer set designed so as to perform the PCR amplification on the objective region is designed through a method for designing a primer set used for the polymerase chain reaction, the method for designing a primer set including a first stage selection step based on a local alignment score and a second stage selection step based o

Abstract: Provided is a method for designing a primer used for a polymerase chain reaction including: a local alignment step of obtaining a local alignment score by performing pairwise local alignment on a base sequence of a primer candidate under a condition that a partial sequence to be subjected to comparison includes the 3? terminal of the base sequence of the primer candidate; and a global alignment step of obtaining a global alignment score by performing pairwise global alignment on a base sequence which has a predetermined sequence length and includes the 3? terminal of the base sequence of the primer candidate and a primer set.

Abstract: There are provided an examination notification output device, an examination notification output method, an examination notification output program, and a gene chromosome examination system capable of outputting information, which is an indicator for determining whether or not a re-examination is required, in a case where it is determined that a re-examination is required for a gene chromosome examination.

Abstract: The cell imaging control device includes a cell detection unit 22 that acquires a cell image by imaging transmitted light or reflected light of undyed cells and detects the cells or structures in the cells in the cell image and an autofocus control unit 24 that calculates an autofocus evaluation value based on image information of the cells or the structures detected by the cell detection unit 22 and outputs an autofocus control signal based on the autofocus evaluation value to an imaging device for capturing the cell image, which is an imaging device having an autofocus function.

Abstract: There are included a colony evaluation unit 31 that acquires an evaluation result of the cell colony in a cell image obtained by imaging the cell colony, a divided region setting unit 32 that sets a plurality of divided regions by dividing the region of the cell colony according to the evaluation result, a display control unit 34 that displays each of the plurality of divided regions, and a region deformation unit 33 that deforms the divided regions according to a change in the form of the cell colony due to an operation on the cell colony. The display control unit 34 changes a display of the divided regions before the change in form of the cell colony to a display of the divided regions after the deformation.

Abstract: A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result.

Abstract: Provided is a pump apparatus capable of improving the performance in a wide operation range from an operation area with a low pressure and a high flow rate to an operation area with a high pressure and a low flow rate while suppressing a rated output of a motor used to drive a pump. A rotation speed of a motor 20 is controlled so that the rotation speed of the motor decreases with an increase in the load of the motor 20 driving a pump unit 10, the rotation speed thereof increases with a decrease in the load thereof, and the load does not exceed a predetermined upper limit. For this reason, it is possible to improve the performance in a wide operation range from an operation area with a low pressure and a high flow rate to an operation area with a high pressure and a low flow rate compared to a method of the related art of uniformly keeping a rotation speed of a motor.