Abstract: The site to which a patch was stuck may be identified even after the patch is removed. A patch for drug delivery includes a drug holding portion and a backing layer. The patch further includes a marker capable of indicating a site to which the patch was stuck even after the patch is removed therefrom.

Abstract: To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.

Abstract: An iontophoresis device includes an electric power source device, a drug administration device and a current control device. The drug administration device may include at least two or more electrode assemblies each holding an ionic drug. The drug administration device may be coupled to the electric power source device. The current control device may control current flowing to respective ones of the electrode assemblies. An amount of the ionic drug is releasable from each of the electrode assemblies at a defined time when transdermally administered to an organism in accordance with the current flowing from the current control device, wherein at least one of the two or more electrode assemblies holds a sleep-inducing agent as the ionic drug, and at least another one of the two or more electrode assemblies holds a stimulant as the ionic drug.

Abstract: An iontophoresis device transdermally administers an active agent, such as a drug ion, to a biological interface of an organism. The iontophoresis device includes a first electrode assembly having a first electrode member, which is electrically coupled to a terminal, of a main electric power source, having a first polarity that is the same polarity as that of a drug ion. The iontophoresis device includes a drug solution reservoir arranged in an electric field generated by the first electrode member and holding a drug, a counter electrode assembly electrically coupled to another terminal (of the main electric power source) having a second polarity that is opposite to the first polarity, and a vibrating portion having an ultrasonic oscillator for oscillating an ultrasonic wave and an ultrasonic vibrator vibrating due to the ultrasonic wave supplied from the ultrasonic oscillator. The ultrasonic vibrator is provided in the vicinity of the active electrode assembly.

Abstract: Provided is a packaged iontophoresis system 15 including: an iontophoresis system 10 including an apparatus body 50 for transdermally delivering an ionized drug by iontophoresis, and a connection part 70 extended from the apparatus body 50 and connected to the apparatus body 50 and a power source 60, the power source 60 supplying power to the apparatus body 50; a package material 80 hermetically packaging the apparatus body 50 and a portion of the connection part 70, by at least a part thereof being welded to the connection part 70; and a cutting guide 400 guiding a cutting line of the package material 80 so that the part of the package material 80 welded to the connection part 70 remains at the connection part 70 when the package material 80 is opened.

Abstract: An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.

Abstract: An iontophoresis device may include: an electric power source; a first electrode assembly coupled to the electric power source; and a second electrode assembly as a counter electrode of the first electrode assembly. The first electrode assembly may include an adhesive portion that facilitates contact between a mucous membrane and the first electrode assembly. The adhesive portion may be placed on a portion of an end surface portion of an electrode assembly, and may be made from a material that exhibits adhesiveness after absorbing an aqueous medium.

Abstract: An electrode assembly for iontophoresis may enable the administration of a non-ionic active agent ionized, or an active agent that is substantially insoluble in water, by iontophoresis. An electrode assembly used for iontophoresis may hold an active agent enclosed in an ionic nanoparticle.

Abstract: An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.

Abstract: Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and/or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.

Abstract: Whether or not a prescribed active agent is properly used may be confirmed. Usage of an active agent to be administered by an active agent injecting device (such as an iontophoresis device) driven by a drive signal may managed through a server based on actual drive information from the active agent injecting device.

Abstract: An iontophoresis device includes active and counter electrode assemblies. The active electrode assembly includes an active electrode element, an outermost ion selective membrane caching an active agent and a further active agent carried by an outer surface of the outermost ion selective membrane. The active electrode assembly may also include an inner active agent reservoir storing additional active agent, an electrolyte reservoir storing electrolyte, an inner ion selective membrane positioned between the electrolyte reservoir and the active agents. The active electrode may also include an inner withdrawable sealing liner between the electrolyte reservoir and the active agents. An outer release liner may protectively cover or overlay the further active agent and/or outer surface prior to use.

Abstract: A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.

Abstract: An shaped iontophoresis device is capable of permeating an active agent (e.g., a drug solution) into an oral cavity, a skin cancer, or the like by iontophoresis in a pinpoint manner. A catheter-type iontophoresis device includes a small working electrode assembly and a small non-working electrode assembly at the tip of a holding portion. A first ion exchange membrane and a fourth ion exchange membrane at the tips of the assemblies are brought into close contact with a target area so that a drug solution is permeated by iontophoresis in a pinpoint manner. The working electrode assembly and the non-working electrode assembly 14 are attached to the tip of a rod-shaped member. The rod-shaped member is detachable from the tip of the holding portion, and is exchangeable integrally with the portion. The iontophoresis device may advantageously take the form of a rod or catheter.

Abstract: An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.

Abstract: An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.

Abstract: One or more electrodes of an iontophoresis device may include a composite ion exchange membrane comprising a first ion exchange membrane of a first polarity and a second ion exchange membrane of a second polarity, or a first ion exchange membrane of the first polarity, a semi-permeable membrane, and a second ion exchange membrane of the second polarity. The respective membranes may be integrally coupled together. This may lead to simplified production processes, automated production, mass production, and reductions in production costs for the iontophoresis device.

Abstract: An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.

Abstract: A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.

Abstract: An iontophoresis device includes an active electrode assembly which comprises an active electrode element and an outermost active electrode ion selective membrane that caches an active agent. The outermost active electrode ion selective membrane may be formed by one or more ion exchange membranes. The active electrode assembly may also comprise an electrolyte and/or one or more inner active electrode ion selective membranes. The inner active electrode ion selective membrane may be a “leaky” ion selective membrane. The inner active electrode ion exchange membrane may be spaced from the outermost active electrode ion selective membrane, for example, by one or more non-ion selective porous membranes or by a buffer material and/or buffer reservoir. An iontophoresis device may also include a counter electrode assembly and/or voltage source.