Patents by Inventor Takeo Yoshioka
Takeo Yoshioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6133443Abstract: Optically active 1,4-dihydropyridine derivatives represented by general formula (I) and anion salts thereof and a production method therefor: ##STR1## (wherein R.sup.1 represents a C.sub.1-6 alkyl group, R.sup.2 represents a nitrogen-containing heterocyclic group forming a quaternary ammonium which may be substituted, and n is an integer of 1, 2 or 3). The optically active 1,4-dihydropyridine derivatives represented by general formula (I) have vasodilating activity and hypotensive activity and are excellent in water solubility so that they are useful as a drug for circulatory system such as a hypotensor or vasodilator.Type: GrantFiled: August 21, 1998Date of Patent: October 17, 2000Assignee: Mercian CorporationInventors: Takashi Nakashima, Kunio Isshiki, Noriaki Sakata, Naoki Agata, Takeo Yoshioka
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Patent number: 6043050Abstract: A biological process for producing steroids hydroxylated at the 25-position thereof comprises adding steroids (excluding cholesterol) to the cells or culture liquid of a microorganism of the genus Amycolata or Sphingomonas capable of hydroxylating the steroids at the 25-position thereof to convert a hydrogen atom bonded to a carbon atom at the 25-position of each steroid into hydroxyl group. By this process, steroids(other than cholesterol) can be biologically hydroxylated at the 25-position by using microorganisms other than those of the genus Streptomyces.Type: GrantFiled: December 23, 1998Date of Patent: March 28, 2000Assignees: Mercian Corporation, Chugai Seiyaku Kabushiki KaishaInventors: Koji Takeda, Tadashi Terasawa, Kazuyuki Dobashi, Takeo Yoshioka
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Patent number: 6030951Abstract: Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be distinguished from the chrysomycins and the like in that the novel C-glycoside compounds have a sugar residue having a higher degree of oxidation, as well as the compound Mer-1020dE comprising only the chromophore thereof. Among these compounds, the C-glycoside compounds are antibiotics which have low toxicity and can strongly inhibit the growth of solid cancer cells in particular.Type: GrantFiled: July 8, 1999Date of Patent: February 29, 2000Assignee: Mercian CorporationInventors: Takashi Nakashima, Tadashi Fujii, Kazuya Sakai, Tomohiro Sameshima, Hiroyuki Kumagai, Takeo Yoshioka
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Patent number: 6020363Abstract: Compounds of the formula (I) ##STR1## wherein R is a hydrogen atom or a C.sub.1-6 alkyl group and n is an integer of 0 or 1, and pharmaceutical preparations thereof are provided. These pharmaceutical preparations are useful for the prevention or treatment of diseases associated with an abnormality in immunological regulatory function or vascularization.Type: GrantFiled: December 17, 1998Date of Patent: February 1, 2000Assignees: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Shin-ichi Hirano, Toshiyuki Mase, Naoki Agata, Hiroshi Iguchi, Naoki Matsumoto, Takeo Yoshioka, Hiroshi Tone, Hiroyuki Kumagai, Masaaki Ishizuki, Tomio Takeuchi
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Patent number: 5906927Abstract: A process for producing L-2-aminoadipic acid, which comprises converting an aminomethyl group of L-lysine into a carboxyl group by use of a culture of a microorganism of the genus Flavobacterium. By this process, L-2-aminoadipic acid can be obtained directly from L-lysine in a high yield. This process is a microbial method which is effective for the mass production.Type: GrantFiled: September 22, 1997Date of Patent: May 25, 1999Assignees: Mercian Corporation, Chugai Seiyaku Kabushiki KaishaInventors: Kuniho Nakata, Takao Narita, Hiroshi Tsunekawa, Takeo Yoshioka
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Patent number: 5811683Abstract: A method for locating a source position of an anomalous signal in a radial bearing comprises using a signal detection sensor, an inner-ring positional detection sensor for detecting a rotational position of a bearing inner ring, and a ball positional detection sensor for detecting a revolution position of bearing-balls. Signals from the signal detection sensor, inner-ring positional detection sensor, and ball positional detection sensor are used to locate positions of contact between balls and the inner or outer ring at a time of anomalous signal generation, within a load zone, as an anomalous signal source position.Type: GrantFiled: April 2, 1997Date of Patent: September 22, 1998Assignee: Agency of Industrial Science & Technology, Ministry of International Trade & IndustryInventors: Takeo Yoshioka, Atsushi Korenaga
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Patent number: 5760238Abstract: Disclosed are 1,4-dihydropyridine derivatives represented by the general formula (I) and salts thereof, as well as optical active 1,4-dihydropyridine derivatives represented by the general formula (II) and salts thereof which are obtained from the derivative by biochemical reactions using microorganisms or enzymes and useful as preventive and therapeutic agents for ischemic heart diseases and hypertension. ##STR1## (wherein x and Y are H, NO.sub.2, CN, halogen; R.sup.1 and R.sup.2 are H, CHO, substituted alkylcarbonyl, crotonyl, cinnamoyl, alkoxycarbonyl, aryloxycarbonyl, benzyloxycarbonyl, carboxybenzoyl, or R.sup.1 and R.sup.2 taken together represent phthaloyl; n is an integer of 1 to 3).Type: GrantFiled: February 25, 1997Date of Patent: June 2, 1998Assignee: Mercian CorporationInventors: Kunio Isshiki, Naoki Matsumoto, Takashi Nakashima, Kazuyuki Dobashi, Takurou Tsuruta, Takeo Yoshioka
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Patent number: 5635395Abstract: (4R)-3-(Substituted aminoalkyl)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-5- carboxylic acids can be prepared efficiently, by reacting bis(substituted aminoalkyl) 1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-3,5-dicarboxylates with a microorganism capable of asymmetric hydrolysis and belonging to the genus Streptomyces, the genus Paecilomyces, the genus Botryodioplodia, the genus Alternaria or the genus Helminthosporium, or a treated product thereof. The compounds are extremely useful as important intermediates for preparation of pharmaceuticals useful for the prevention and treatment of angina pectoris, hypertension, etc.Type: GrantFiled: February 21, 1995Date of Patent: June 3, 1997Assignees: Mercian Corporation, Taisho Pharmaceutical Co., Ltd.Inventors: Kunio Isshiki, Takashi Nakashima, Takeo Yoshioka, Hiroshi Tsunekawa, Takashi Adachi, Tomomi Ota
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Patent number: 5541303Abstract: A compound of the following formula is provided: ##STR1## wherein A represents a carbonyl group which may be protected; B represents an aldehyde group which may be protected; R.sup.1 represents a hydroxyl group which may be protected; R.sup.2 represents a hydrogen atom or acyl group; W represents a hydrogen atom, hydroxyl group, lower alkanoyloxy group or substituted sulfonyloxy group; Y represents a hydrogen atom, halogen atom, hydroxyl group or substituted sulfonyloxy group; and broken line "-------" represents a double bond or single bond. This compound is useful for producing 3,4'-dideoxymycaminosyltylonolide useful as an antimicrobial agent.Type: GrantFiled: July 13, 1994Date of Patent: July 30, 1996Assignee: Zaidan Hojin Biseibutsu Kagaku KenkyukaiInventors: Tomio Takeuchi, Sumio Umezawa, Osamu Tsuchiya, Shunji Kageyama, Toshiaki Miyake, Naoki Matsumoto, Kaichiro Kominato, Hiroshi Tanaka, Takeo Yoshioka
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Patent number: 5395941Abstract: Optically active 1,4-dihydropyridine derivatives represented by general formula (I), process for preparing compounds (Ic) (in general formula (I) , R.sup.1 is a lower alkyl group), process for preparing compounds represented by general formula (II) by hydrolyzing the compounds (Ic) under acidic conditions, process for preparing compounds represented by general formula (II) by solvolysis, under basic conditions, of compounds represented by general formula (III); ##STR1## wherein R.sup.1 is H, a lower alkyl group, a cyanoethyl group, a lower alkanoylaminoethyl group, or a lower dialkylaminoethyl group; R.sup.2 is a 2-tetrahydropyranyl group or a lower alkyloxymethyl group; R.sup.3 is a cyano group, a lower dialkylamino group or a lower alkanoylamino group; and R.sup.4 is a lower alkyl group. The compounds of general formula (I) and (II) are intermediate compounds for preparing optically active 1,4-dihydropyridine derivatives which are useful as medicines for circulatory organs.Type: GrantFiled: March 22, 1994Date of Patent: March 7, 1995Assignee: Mercian CorporationInventors: Kunio Isshiki, Takashi Nakashima, Hiroshi Tanaka, Takeo Yoshioka
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Patent number: 5302270Abstract: An oxygen concentration controlling element where the shortest distance between the anode and cathode separated by a solid electrolyte film is set not larger than 50 .mu.m, thereby to accelerate the back-diffusion of water generated in the cathode to the anode and dispense with a tank or a pump for supplying water to the anode. An oxygen concentration or humidity controlling apparatus where a photoelectric element is disposed at an opening of a to-be-controlled space to the atmospheric air and the electric energy from the photoelectric element is accumulated in a secondary battery, thus realizing space-saving apparatus which can operate continuously though the power is turned off, and a humidity controlling apparatus functioning both as a humidifier and as a dehumidifier.Type: GrantFiled: March 12, 1993Date of Patent: April 12, 1994Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Shiro Yamauchi, Takeo Yoshioka, Kenro Mitsuda, Toshiaki Murahashi
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Patent number: 5232943Abstract: Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a pharmaceutical composition comprising one of these antibiotics and useful as an antifungal agent.Type: GrantFiled: May 20, 1992Date of Patent: August 3, 1993Assignee: Mercian CorporationInventors: Hitosi Agematu, Yoshio Watanabe, Hiroyuki Chiba, Rei Kaneto, Norio Shibamoto, Takeo Yoshioka, Toshihiko Kumamoto, Hiroshi Nishida, Rokuro Okamoto
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Patent number: 5223519Abstract: 4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces karnatakensis are disclosed. Also disclosed are the pharmaceutical composition comprising the same and a method for treating circulatory diseases comprising the step of administering said compound to a patient.Type: GrantFiled: December 13, 1991Date of Patent: June 29, 1993Assignee: Mercian CorporationInventors: Shin-ichi Hirano, Yoshio Watanabe, Kaichiro Kominato, Naoki Agata, Yutaka Hara, Norio Shibamoto, Takeo Yoshioka, Tomoyuki Kioka, Hiroshi Iguchi, Masataka Shirai, Hiroshi Tone, Rokuro Okamoto
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Patent number: 5195577Abstract: A boiling type cooling device for cooling power semiconductors includes an evaporator containing an aqueous solution of ethylene glycol as a cooling medium, a condenser; and a vapor and liquid return pipe. According to a first aspect, the lowest portion of the condensor is at a level higher than the top surface of the cooling medium in the evaporator, the bottom surfaces of the condensor being tilted downward toward the top end of the liquid return pipe. According to another aspect, a pump is provided in the liquid return pipe for driving cooling medium to the evaporator. According to still other aspects, the liquid return pipe is covered with a heat insulating material, or a rubber string extends centrally therewithin. A deaeration device for the aqueous solution of ethylene glycol includes two separate deaeration baths and a mixing bath.Type: GrantFiled: October 24, 1990Date of Patent: March 23, 1993Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Takashi Kameda, Nobuyoshi Takahashi, Takeo Yoshioka, Kenichi Mori, Masahiro Ashiya
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Patent number: 5183883Abstract: Adriamycin derivatives represented by formula (I) ##STR1## wherein R denotes a divalent hydrocarbon group,CD denotes a cyclodextrin residue,m is 1 to 8, andn is 0 to 8.The compounds exhibit excellent anti-cancer activity over a wide administration range, have low toxicity and sustained release, and maintain activity for a long period of time; thus, they are quite useful as an anti-cancer agent.Type: GrantFiled: September 27, 1991Date of Patent: February 2, 1993Assignee: Mercian CorporationInventors: Hiroshi Tanaka, Kaichiro Kominato, Takeo Yoshioka, Hiroshi Iguchi, Shin-ichi Hirano, Yasuo Okajima, Reijko Yamamoto, Masataka Shirai, Hiroshi Nishida, Hiroshi Tone, Rokuro Okamoto
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Patent number: 5149802Abstract: A process for producing 2-azetidinone derivatives represented by formula ##STR1## wherein R.sup.1 denotes a protecting group of a hydroxyl group,Z denotes a hydrogen atom or a protecting group of an amino group, andQ denotes ##STR2## in which X denotes a halogen atom, Y denotes a halogen atom or OR.sup.2, R.sup.2 denotes a hydrogen atom or a protecting group of a carboxyl group, and Y.sup.2 denotes OR.sup.3 or SR.sup.4 in which R.sup.3 denotes a hydrogen atom, a protecting group of a carboxyl group or an ester residue and R.sup.4 denotes an ester residue.Type: GrantFiled: July 10, 1991Date of Patent: September 22, 1992Assignee: Mercian CorporationInventors: Takeo Yoshioka, Ryoichi Miyata, Toshio Tsuchida, Hiroshi Tone, Rokuro Okamoto
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Patent number: 5091370Abstract: An angolamycin derivative represented by the following formula ##STR1## wherein X represents an acetyl, methanesulfonyl, methylthio, benzoyl or methoxy group. This compound is useful as a medicament such as antibacterial agent and an animal feed additive.Type: GrantFiled: June 18, 1990Date of Patent: February 25, 1992Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Azuma Watanabe, Koichiro Kominato, Hiroshi Tone, Rokuro Okamoto, Tsutomu Sawa, Tomio Takeuchi
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Patent number: 5005181Abstract: A gas control device in a halogen gas laser device which comprises: a filter for receiving a small quantity of deteriorated gas from the upstream portion of the laser gas circulating path to convert it into a low-boiling-point gas; and a gas detector for measuring the density of the low-boiling-point gas thus formed, to estimate the halogen gas density, and outputting, when the density is lower than a predetermined value, an instruction signal to supply halogen gas.Type: GrantFiled: September 20, 1989Date of Patent: April 2, 1991Assignee: Mitsubishi Denki K.K.Inventors: Takeo Yoshioka, Tadao Minagawa
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Patent number: 4997922Abstract: 14-Trifluoromethanesulfonyloxydaunomycin represented by the following formula ##STR1## and its salt. This compound is useful as an intermediate for production of adriamycin.Type: GrantFiled: January 17, 1989Date of Patent: March 5, 1991Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Toshio Tsuchida, Ryoichi Miyata, Hiroshi Tone, Rokuro Okamoto
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Patent number: 4996314Abstract: A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.Type: GrantFiled: September 19, 1988Date of Patent: February 26, 1991Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura