Patents by Inventor Takeo Yoshioka
Takeo Yoshioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4939248Abstract: This invention provides compounds of the formula ##STR1## wherein Y represents an acetyl, 1-hydroxyethyl or 1-fluoroethyl group, R.sub.1 represents a hydrogen atom or an easily splittable amino-protecting group, and R.sub.2 and R.sub.3 are identical or different and each represents a hydrogen atom, a lower alkyl group, a phenyl group, a benzyl group or a diphenylmethyl group, or R.sub.2 and R.sub.3 together represent a lower alkylene group; and processes for production thereof. These compounds are useful as synthesis intermediates for production of various medicines, particulary carbapenam or carbapenem antibiotics, such as a carbapenem antibiotic of the following formula which has excellent antimicrobial activity and relatively good stability to kidney dehydropeptidase.Type: GrantFiled: August 18, 1988Date of Patent: July 3, 1990Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Machiko Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4933439Abstract: Tylosin derivatives represented by the following general formula (I): ##STR1## [wherein R denotes a hydrogen atom, acetyl, propionyl or a radical of Si(R.sup.2).sub.3 (in which R.sup.2 is a lower alkyl group), and R.sup.1 stands for a hydrogen atom or a radical of Si(R.sup.2 .sub.3 ] are useful as intermediates for the synthesis of 4"-acyl derivatives of tylosin because, after introduction of any desired acyl group at the 4"-hydroxyl group, the silyl protective group can be readily removed without liberation of the acyl group. This invention also provides processes for producing the tylosin derivatives. More specifically, it provides a melthod of selectively protecting 2'- and 4"'-hydroxyl groups of tylosin (those of higher reactivity among the hydroxyl groups involved); a method of selectively protecting only the 4"'-hydroxyl group of tylosin; a method of selectively protecting the 3- and 4"'-hydroxyl groups of 2'-O-acyltylosin; and a method of protecting 3-, 2'- and 4"'-hydroxyl groups of tylosin.Type: GrantFiled: November 17, 1988Date of Patent: June 12, 1990Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Azuma Watanabe, Hiroyuki Chiba, Kaichiro Kominato, Kohki Kiyoshima, Yasuo Fukagawa, Hiroshi Tone, Rokuro Okamoto
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Patent number: 4908729Abstract: A lightning arrester monitor which consists of an oxygen gas sensor provided in a lightning arrester having a zinc-oxide-type element made of zinc oxide, the main component thereof, and other oxides added thereto, the oxygen gas sensor measures the oxygen concentration of the element which increases as degradation thereof goes on. The monitor makes it possible to assess degradation of the zinc-oxide-type element with ease, without requiring any complicated electrical circuit for detecting leakage current.Type: GrantFiled: December 14, 1988Date of Patent: March 13, 1990Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Takeo Yoshioka, Masahiro Kobayashi, Tadao Minagawa, Katsu Ujita
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Patent number: 4853407Abstract: Compounds represented by formula ##STR1## wherein Y.sup.1 and Y.sup.2 are identical or different, and respectively denote benzoylamino groups or phthalimide groups. This compound is useful for inhibition of dipeptidase.Type: GrantFiled: May 20, 1988Date of Patent: August 1, 1989Assignee: Sanraku IncorporatedInventors: Norio Shibamoto, Takeo Yoshioka, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4839767Abstract: An element for detecting internal faults in an insulating gas charged electrical apparatus comprises a substrate disposed in the electrical apparatus charged with an insulating gas, a pair of electrodes disposed on the substrate, and a thin metal film covering the pair of electrodes and the exposed surface of the substrate. This film is capable of producing fluorides with low conductivity upon reacting with a decomposed gas produced by internal faults of the electrical apparatus. Since the thin metal film exhibits high response characteristics readily in reaction with even a trace amount of a decomposed gas, it is possible to promptly detect faults occurring in the electrical apparatus, such as a partial discharge or local heating. In addition, a device for detecting internal faults in an insulating gas charge electrical apparatus using the internal fault detection element utilizes an optical signal for transmitting signals.Type: GrantFiled: January 27, 1988Date of Patent: June 13, 1989Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Takeo Yoshioka, Tadao Minagawa, Toshihiro Suzuki, Ichiro Yamasaki, Yoshifumi Matsushita
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Patent number: 4812563Abstract: A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an alkyl group or a substituted or unsubstituted aralkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.Type: GrantFiled: March 10, 1987Date of Patent: March 14, 1989Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4778883Abstract: An azetidinone derivative of the formula ##STR1## wherein R.sub.1 represents a formyl group, a carboxyl group, an acetyloxy group or a group of the formula ##STR2## in which R.sub.2 and R.sub.3 each represent a lower alkyl group or together represent a lower alkylene group, and Z represents a hydrogen atom or an amino-protecting group.Type: GrantFiled: February 18, 1987Date of Patent: October 18, 1988Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4638815Abstract: An improved water pipe for a cigarette is proposed which has a bowl, a stem and a smoke tube extending through the bowl so as to reach into water contained in the bottom of the bowl. A ball retained at bottom of the smoke tube prevents water from entering the hole and cigarette and serves to bring nicotine up and out of the smoke tube.Type: GrantFiled: December 16, 1985Date of Patent: January 27, 1987Inventor: Takeo Yoshioka
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Patent number: 4612372Abstract: Novel tylosin derivatives are represented by formula: ##STR1## wherein R represents a hydrogen atom, an acetyl group or a propionyl group; X represents a group --CO-- or --SO.sub.2 --; Y represents a fluorine atom, an acetyl group, a methanesulfonyl group, a methylthio group, a benzoyl group or a methoxy group bound to the benzyl group at the 2-position or 4-position; and Z represents a hydrogen atom or a D-mycinose residue: ##STR2## The tylosin derivatives which are antibiotics of macrolide type provide improved antibacterial activity and improved ability of absorption and excretion in vivo.Type: GrantFiled: July 12, 1985Date of Patent: September 16, 1986Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Miharu Maeda, Rokuro Okamoto, Yasutaka Shimauchi, Tomoyuki Ishikura, Tsutomu Sawa, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4528397Abstract: An aminocarboxylic acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2, independently from each other, represent a hydrogen atom or an alkyl group which may have a substituent, and Y represents --NH-- or --S--, provided that when Y represents --NH--, at least one of R.sub.1 and R.sub.2 represents an alkyl group which may have a substituent. These compounds have excellent inhibitory activity on dipeptidase in animals, and are useful for administration in combination with carbapenem antibiotics.Type: GrantFiled: March 29, 1983Date of Patent: July 9, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Norio Shibamoto, Takeo Yoshioka, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4517127Abstract: A compound represented by the following formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, R.sub.2 represents a group of the formula --CH.sub.2 NO.sub.2, --CN.fwdarw.O or ##STR2## in which A represents a group of the formula ##STR3## in which R.sub.4 represents a hydrogen atom or an alkoxycarbonyl group, R.sub.5 represents a phenyl, alkoxycarbonyl or alkanoyloxymethyl group, R.sub.6 represents an alkyl group and R.sub.7 represents a phenyl, naphthyl, pyridyl, furyl or thienyl group; and R.sub.3 represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group, and a process for production thereof.Type: GrantFiled: December 9, 1983Date of Patent: May 14, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Takeo Yoshioka, Kenichi Yamamoto, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura
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Patent number: 4508648Abstract: Novel phosphoric ester of antibiotic OA-6129 presented by the formula ##STR1## wherein R is a hydrogen atom, hydroxyl or hydroxysulfonyloxy, and its salts and the preparation method thereof.Type: GrantFiled: September 24, 1982Date of Patent: April 2, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Katsuro Kubo, Takeo Yoshioka, Mitsuyasu Okabe, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4471186Abstract: An abnormal condition detector detects an abnormal condition of an electric apparatus by sampling an insulating fluid filled in the electric apparatus under a pressurized condition and detecting a change of the condition of an indicator induced by an acidic gas in the sampled insulating fluid.Type: GrantFiled: August 6, 1982Date of Patent: September 11, 1984Assignee: Mitsubishi Denki Kabushiki KaishaInventor: Takeo Yoshioka
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Patent number: 4451401Abstract: A compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or a methyl group,R.sup.1 represents a hydrogen atom or an ester residue, andR.sup.2 and R.sup.3 represent hydrogen atoms respectively, or taken together, a group of the formula ##STR2## in which each of R.sup.4 and R.sup.5 represents a hydrogen atom, a lower alkyl group or a phenyl group,and its salt; and a process for the production thereof.Type: GrantFiled: July 1, 1982Date of Patent: May 29, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
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Patent number: 4426390Abstract: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.Type: GrantFiled: September 29, 1981Date of Patent: January 17, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
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Patent number: 4418192Abstract: Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)- (1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.Type: GrantFiled: April 20, 1982Date of Patent: November 29, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Hiroshi Tanaka, Takeo Yoshioka, Yasutaka Shimauchi, Toshikazu Oki, Tomoyuki Ishikura, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4337199Abstract: Novel antibiotic .beta.-lactam compounds, i.e. 7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives of the following formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or a hydroxyl group,R.sub.2 represents a lower alkyl group, a hydroxy lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a cyclohexyl group, a phenyl group or a 5- or 6-membered aromatic heterocyclic group containing 1 or 2 nitrogen atoms, andR.sub.3 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralkyl group containing 7 to 20 carbon atoms,and the salts thereof; processes for production thereof; use thereof as antimicrobial agents; and novel intermediates for production of the compounds of formula (I).Type: GrantFiled: May 6, 1980Date of Patent: June 29, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Takeo Yoshioka, Kenichi Yamamoto, Kaoru Yamada, Yasuyuki Kato, Yasutaka Shimauchi, Tomoyuki Ishikura