Patents by Inventor Takeshi Masaki

Takeshi Masaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10993972
    Abstract: Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these. Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: May 4, 2021
    Assignees: Shinshu University, Anaeropharma Science, Inc.
    Inventors: Yuko Wada, Yuko Shimatani, Takashi Yano, Takeshi Masaki
  • Patent number: 10880997
    Abstract: Disclosed is a stretchable member with a metal foil including a stretchable resin base material, and a conductive metal foil provided on the stretchable resin base material. A surface of the metal foil on the stretchable resin base material side is a roughened surface having surface roughness Ra of 0.1 ?m to 3 ?m.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 29, 2020
    Assignee: SHOWA DENKO MATERIALS CO., LTD.
    Inventors: Tangyii Sim, Kumpei Yamada, Takashi Kawamori, Takeshi Masaki
  • Publication number: 20200154563
    Abstract: Disclosed is a stretchable member with a metal foil including a stretchable resin base material, and a conductive metal foil provided on the stretchable resin base material. A surface of the metal foil on the stretchable resin base material side is a roughened surface having surface roughness Ra of 0.1 ?m to 3 ?m.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 14, 2020
    Inventors: Tangyii SIM, Kumpei YAMADA, Takashi KAWAMORI, Takeshi MASAKI
  • Patent number: 10563208
    Abstract: The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus Bifidobacterium, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus Bifidobacterium; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus Bifidobacterium, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: February 18, 2020
    Assignee: Anaeropharma Science, Inc.
    Inventors: Koichi Koseki, Koichiro Shioya, Satoshi Kobayashi, Yuko Shimatani, Takeshi Masaki, Hitomi Shimizu, Tomio Matsumura, Masami Okabe, Kengo Inoue
  • Publication number: 20190320527
    Abstract: Disclosed is a wiring substrate 1 including a stretchable resin layer 3 and a conductor foil or conductor plating film 5 which is provided on the stretchable resin layer 3 and forms a wiring pattern.
    Type: Application
    Filed: November 14, 2017
    Publication date: October 17, 2019
    Inventors: Takeshi MASAKI, Tangyii SIM, Kumpei YAMADA, Tadahiro OGAWA, Takashi KAWAMORI
  • Patent number: 10443061
    Abstract: An object is to provide a signal peptide that can secrete a heterologous polypeptide with high efficiency outside the bacterial cell in a bacterium of the genus Bifidobacterium, an expression cassette that can secrete a heterologous polypeptide with high efficiency outside the bacterial cell, a heterologous polypeptide expression vector, a bacterium of the genus Bifidobacterium capable of secreting a heterologous polypeptide. Means for attaining the object is a bacterium of the genus Bifidobacterium transformed by a vector having an expression cassette sequentially comprising a promoter DNA functioning in a bacterium of the genus Bifidobacterium, a DNA encoding the secretory signal peptide, a DNA encoding a scFv antibody having an antitumor activity, and a terminator DNA functioning in the bacterium of the genus Bifidobacterium; and capable of secreting the scFv antibody with high efficiency outside the bacterial cell.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: October 15, 2019
    Assignee: Anaeropharma Science, Inc.
    Inventors: Koichi Koseki, Takeshi Masaki, Koichiro Shioya, Hitomi Shimizu, Masao Tsukamoto, Satoshi Kobayashi, Tomio Matsumura, Yuko Shimatani
  • Patent number: 10344093
    Abstract: It is an object of the present invention to provide signal sequence information capable of secreting an antibody to the outside of cells in generation of the antibody by microorganisms of genus Bifidobacterium, and an antibody expression vector capable of secreting an antibody to the outside of cells by utilizing the signal sequence information. As a means for achieving the aforementioned object, there is prepared Bifidobacterium longum, which is transformed with a vector having inserted thereinto a DNA insert comprising the 5?-terminus of an antibody gene linked to the 3?-terminus of a DNA encoding a signal peptide-linker conjugate having a linker linked to the C-terminus of a signal peptide consisting of an amino acid sequence shown in SEQ ID NO: 1.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: July 9, 2019
    Assignee: Shinshu University
    Inventors: Shun-ichiro Taniguchi, Yasuto Akiyama, Takeshi Masaki, Hitomi Shimizu
  • Publication number: 20180360893
    Abstract: Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these. Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.
    Type: Application
    Filed: January 18, 2016
    Publication date: December 20, 2018
    Applicants: Shinshu University, Anaeropharma Science, Inc.
    Inventors: Yuko Wada, Yuko Shimatani, Takashi Yano, Takeshi Masaki
  • Publication number: 20170260534
    Abstract: The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus Bifidobacterium, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus Bifidobacterium; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus Bifidobacterium, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.
    Type: Application
    Filed: December 2, 2015
    Publication date: September 14, 2017
    Inventors: Koichi KOSEKI, Koichiro SHIOYA, Satoshi KOBAYASHI, Yuko SHIMATANI, Takeshi MASAKI, Hitomi SHIMIZU, Tomio MATSUMURA, Masami OKABE, Kengo INOUE
  • Publication number: 20170218072
    Abstract: It is an object of the present invention to provide signal sequence information capable of secreting an antibody to the outside of cells in generation of the antibody by microorganisms of genus Bifidobacterium, and an antibody expression vector capable of secreting an antibody to the outside of cells by utilizing the signal sequence information. As a means for achieving the aforementioned object, there is prepared Bifidobacterium longum, which is transformed with a vector having inserted thereinto a DNA insert comprising the 5?-terminus of an antibody gene linked to the 3?-terminus of a DNA encoding a signal peptide-linker conjugate having a linker linked to the C-terminus of a signal peptide consisting of an amino acid sequence shown in SEQ ID NO: 1.
    Type: Application
    Filed: April 17, 2015
    Publication date: August 3, 2017
    Inventors: Shun-ichiro Taniguchi, Yasuto Akiyama, Takeshi Masaki, Hitomi Shimizu
  • Publication number: 20170183667
    Abstract: An object is to provide a signal peptide that can secrete a heterogeneous polypeptide with high efficiency outside the bacterial cell in a bacterium of the genus Bifidobacterium, an expression cassette that can secrete a heterogeneous polypeptide with high efficiency outside the bacterial cell, a heterogeneous polypeptide expression vector, a bacterium of the genus Bifidobacterium capable of secreting a heterogeneous polypeptide. Means for attaining the object is a bacterium of the genus Bifidobacterium transformed by a vector having an expression cassette sequentially comprising a promoter DNA functioning in a bacterium of the genus Bifidobacterium, a DNA encoding the secretory signal peptide, a DNA encoding a scFv antibody having an antitumor activity, and a terminator DNA functioning in the bacterium of the genus Bifidobacterium; and capable of secreting the scFv antibody with high efficiency outside the bacterial cell.
    Type: Application
    Filed: April 17, 2015
    Publication date: June 29, 2017
    Inventors: Koichi Koseki, Takeshi Masaki, Koichiro Shioya, Hitomi Shimizu, Masao Tsukamoto, Satoshi Kobayashi, Tomio Matsumura, Yuko Shimatani
  • Publication number: 20150193080
    Abstract: A touch pad with an antenna includes a substrate on an upper side of which an operation surface having a predetermined operation region is set, an electrode group for detecting capacitance configured to be arranged in a region of the substrate corresponding to the operation region, and an antenna for wireless communication configured to be arranged in a region located on a lower side of the substrate, the region overlapping with an electrode forming region in which the electrode group for detecting capacitance is formed, as viewed from above. The electrode group for detecting capacitance includes a first electrode group extended in a predetermined first direction and a second electrode group extended in a second direction perpendicular to the first direction, and the antenna is extended in a direction intersecting with the first direction and the second direction.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 9, 2015
    Inventors: Hiroaki Takahashi, Takahiro Murakami, Takeshi Masaki
  • Publication number: 20140362038
    Abstract: A touch pad with an antenna includes an electrode, control means for detecting proximity and a proximate position of an object on the basis of a change in capacitance which is associated with the proximity of the object to the electrode, an antenna, and antenna driving means for supplying power to the antenna. When the proximity of the object is not detected, the control means controls driving of the antenna driving means to set an output of the antenna to an output during ordinary driving. When the proximity of the object is detected, the control means controls driving of the antenna driving means to attenuate the output of the antenna with respect to the output during ordinary driving or to set the output of the antenna to zero.
    Type: Application
    Filed: April 10, 2014
    Publication date: December 11, 2014
    Applicant: ALPS ELECTRIC CO., LTD.
    Inventors: Takahiro MURAKAMI, Sadakazu SHIGA, Takeshi MASAKI, Hiroaki TAKAHASHI
  • Publication number: 20140166262
    Abstract: A cooling apparatus 1 cools a casting mold K with a refrigerant circulating in a refrigerant passage pipe 2 and comprises an expansion tank 3 for pressurizing the refrigerant to a pressure at which the refrigerant has a set boiling temperature T0 at which the refrigerant boils, a mold cooling section 4 inside the casting mold K for cooling the casting mold K through vaporization heat of the refrigerant boiling, an orifice portion 5 that is formed upstream of the mold cooling section 4, a pump 6 that is attached downstream of the expansion tank 3 and upstream of the orifice portion and pumps out the refrigerant pressurized by the pressurizing unit to the orifice portion, and a heating device 7 attached downstream of the pump 6 and upstream of the orifice portion 5 for heating the refrigerant to a temperature T2 close to the set boiling temperature T0.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 19, 2014
    Applicant: HONDA MOTOR CO., LTD.
    Inventors: Keita Yoshiara, Tomonori Taoka, Takeshi Masaki, Takeshi Tajima
  • Publication number: 20080245722
    Abstract: A filtration apparatus including a tubular element (17) for purifying wastewater that flows from outside to inside, and a spray tube (21) for spraying cleaning water onto the external peripheral surface of the tubular element. In the first step, the external peripheral surface of the tubular element is cleaned and most of solid matter is removed. In the second step, compressed air is fed to the tubular element, and fine solid matter that is embedded in the filter is removed by backwashing.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 9, 2008
    Applicants: HONDA MOTOR CO., LTD., GE TECHNO CO., LTD
    Inventors: Hiroshi Koike, Takashi Suzuki, Susumu Nagai, Takeshi Masaki, Hisamatsu Muto
  • Patent number: 7264037
    Abstract: Made up of a step of preparing a map expressing a correlation between solid phase percentage and viscosity of a slurry-form semi-solid metal (27) for a given metal composition; a step of setting a target viscosity corresponding to a target solid phase percentage using this map; a viscosity measuring step of measuring the viscosity of a semi-solid metal in a vessel (13) while cooling it; and a step of carrying out cooling until this viscosity reaches the target viscosity, by these steps being carried out in from the preparation of the map expressing the correlation between solid phase percentage and viscosity of the semi-solid metal to the end of cooling of the semi-solid metal the solid phase percentage of the semi-solid metal is made to match the target solid phase percentage.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: September 4, 2007
    Assignee: Honda Motor Co., Ltd.
    Inventors: Koichi Kuroki, Takeshi Masaki, Hideaki Onda, Shinji Kazama, Tetsuya Muramatsu, Tetsuji Umemoto, Kenji Ohwada, Tomonori Taoka, Akira Noda, Hiromichi Baba, Kenichi Yasuda
  • Patent number: 7214900
    Abstract: An electrical discharge machining apparatus includes a work electrode adapted to support a work immersed in a working fluid, a tool electrode located opposing the work electrode with a predetermined gap therebetween, a capacitor that is connected between the work electrode and the tool electrode to provide a series of voltage pulses, a charging circuit having a power supply and a first switching element which are connected in series to the capacitor, a charge regulating circuit having a second switching element connected in series to the capacitor, and a control unit that controls the first and second switching elements, such that the first switching element turns on, and then the second switching element turns on before the first switching element turns off. Then, one voltage pulse, having a leading edge corresponding to the turning on of the first switching element and a trailing edge corresponding to the turning on of the second switching element, is generated.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 8, 2007
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Masakazu Hiraishi, Masahiro Muro, Takeshi Masaki, Toshihiko Wada
  • Publication number: 20060151137
    Abstract: Made up of a step of preparing a map expressing a correlation between solid phase percentage and viscosity of a slurry-form semi-solid metal (27) for a given metal composition; a step of setting a target viscosity corresponding to a target solid phase percentage using this map; a viscosity measuring step of measuring the viscosity of a semi-solid metal in a vessel (13) while cooling it; and a step of carrying out cooling until this viscosity reaches the target viscosity, by these steps being carried out in from the preparation of the map expressing the correlation between solid phase percentage and viscosity of the semi-solid metal to the end of cooling of the semi-solid metal the solid phase percentage of the semi-solid metal is made to match the target solid phase percentage.
    Type: Application
    Filed: June 29, 2004
    Publication date: July 13, 2006
    Applicant: HONDA MOTOR CO., LTD
    Inventors: Koichi Kuroki, Takeshi Masaki, HIdeaki Onda, Shinji Kazama, Tetsuya Muramatsu, Tetsuji Umemoto, Kenji Ohwada, Tomonori Taoka, Akira Noda, Hiromichi Baba, Kenichi Yasuda
  • Publication number: 20060006150
    Abstract: An electrical discharge machining apparatus includes a work electrode adapted to support a work immersed in a working fluid, a tool electrode located opposing the work electrode with a predetermined gap, a capacitor that is connected between the work electrode and the tool electrode to provide a series of voltage pulses, a charging circuit having a power supply and a first switching element which are connected in series to the capacitor, a charge regulating circuit having a second switching element connected in series to the capacitor, and a control unit that controls the first and second switching elements, such that the first switching element turns on, and then the second switching element turns on before the first switching element turns off. Then, one voltage pulse, having a leading edge corresponding to the turn on of the first switching element and a trailing edge corresponding to the turn on of the second switching element, is generated.
    Type: Application
    Filed: December 17, 2004
    Publication date: January 12, 2006
    Inventors: Masakazu Hiraishi, Masahiro Muro, Takeshi Masaki, Toshihiko Wada
  • Patent number: 6809285
    Abstract: In a micro electro discharge machining method and apparatus, the shapes of minute holes are transferred to a tool electrode through a plate electrode serving as an intermediate electrode, and a workpiece is machined using the tool electrode. As a result, the time for machining is reduced. During the electro discharge machining process, the relative distance between the tool electrode and the plate electrode or the workpiece is changed at a prescribed frequency and discharge pulse output is controlled in synchronization with the change in the relative distance between the tool electrode and the plate electrode or the workpiece, so that high precision machining is enabled.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: October 26, 2004
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Takeshi Masaki, Toshihiko Wada