Patents by Inventor Tamaki Wada
Tamaki Wada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11889829Abstract: A liquid for cryopreserving a cell and a liquid for administration of a mammalian cell capable of cryopreserving a mammalian cell and effectively suppressing cell death after thawing, and a method for cryopreserving a mammalian cell using the cell cryopreservation liquid. The liquid is an isotonic solution that includes 2.0 to 6.0% (w/v) of trehalose or a derivative thereof, or a salt of the trehalose or the derivative, 4.0 to 7.0% (w/v) of dextran or a derivative thereof, or a salt of the dextran or the derivative, and DMSO or glycerin.Type: GrantFiled: November 8, 2017Date of Patent: February 6, 2024Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Masuhiro Nishimura, Natsuki Watanabe, Yasutaka Fujita, Tamaki Wada
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Patent number: 11155782Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: GrantFiled: June 17, 2019Date of Patent: October 26, 2021Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa Okairi, Masuhiro Nishimura, Tamaki Wada
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Patent number: 10945427Abstract: The problem of the present invention is to provide a method for preserving mammalian cells over a long period of time using a solution for cell transplantation, capable of effectively suppressing cell death when the mammalian cells have been preserved, and the solution for cell transplantation. The present invention is characterized in that mammalian cells are preserved in a physiological aqueous solution for cell transplantation, comprising 2.0 to 6.0% (w/v) of trehalose, a derivative thereof, or a salt of trehalose or the derivative (a trehalose) and 4.0 to 7.0% (w/v) of dextran, a derivative thereof, or a salt of dextran or the derivative (a dextran). The effects of a trehalose and a dextran contained in the physiological aqueous solution for cell transplantation can suppress a decrease in the cell survival rate when mammalian cells are preserved for a long period of time (at least 14 days).Type: GrantFiled: June 18, 2014Date of Patent: March 16, 2021Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Masuhiro Nishimura, Tamaki Wada, Chikage Shirakawa, Masako Doi
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Publication number: 20200385594Abstract: The purpose of the present invention is to provide an ink for ink-jet printers, the ink being able to be reduced in the content of an electroconductive agent and having low resistance. The ink for ink-jet printers of a charge control type according to the present invention, which is provided in order to overcome the problem, is characterized by comprising a resin, a pigment, an electroconductive agent, and a nonaqueous solvent, the electroconductive agent having a salt structure which generates an anion and a cation in the nonaqueous solvent, the anion having a trifluoromethylsulfonyl group and the cation being a quaternary ammonium cation or having an unsaturated heterocyclic structure.Type: ApplicationFiled: February 20, 2019Publication date: December 10, 2020Inventors: Hiroshi SASAKI, Takuya OTOWA, Masahiko OGINO, Keisuke NAGAI, Tamaki WADA
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Publication number: 20200077643Abstract: A liquid for cryopreserving a cell and a liquid for administration of a mammalian cell capable of cryopreserving a mammalian cell and effectively suppressing cell death after thawing, and a method for cryopreserving a mammalian cell using the cell cryopreservation liquid. The liquid is an isotonic solution that includes 2.0 to 6.0% (w/v) of trehalose or a derivative thereof, or a salt of the trehalose or the derivative, 4.0 to 7.0% (w/v) of dextran or a derivative thereof, or a salt of the dextran or the derivative, and DMSO or glycerin.Type: ApplicationFiled: November 8, 2017Publication date: March 12, 2020Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Masuhiro NISHIMURA, Natsuki WATANABE, Yasutaka FUJITA, Tamaki WADA
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Publication number: 20190382721Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: ApplicationFiled: June 17, 2019Publication date: December 19, 2019Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa OKAIRI, Masuhiro NISHIMURA, Tamaki WADA
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Patent number: 10370639Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: GrantFiled: July 17, 2017Date of Patent: August 6, 2019Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa Okairi, Masuhiro Nishimura, Tamaki Wada
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Patent number: 10265346Abstract: A mammalian cell suspension prevents pulmonary embolism formation during administration of mammalian cells, such as mammalian stem cells, through a blood vessel, and a preventive agent against pulmonary embolism formation during administration of mammalian cells through a blood vessel. suspending mammalian cells, such as mammalian stem cells, are suspended in a physiological aqueous solution containing trehalose or its derivative, or a salt thereof as an active ingredient to prepare a mammalian cell suspension for preventing pulmonary embolism formation during administration of the mammalian cells through a blood vessel, including the mammalian cells and trehalose or its derivative, or a salt thereof as active ingredients. Examples of the mammalian cells can include pancreatic islet cells, dendritic cells, natural killer cells, alpha/beta T cells, gamma/delta T cells, and cytotoxic T lymphocytes in addition to mammalian stem cells.Type: GrantFiled: May 2, 2013Date of Patent: April 23, 2019Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Tamaki Wada, Masako Doi, Takeshi Kikuchi, Eiji Kobayashi
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Patent number: 10087421Abstract: The present invention provides a mammalian stem cell suspension containing mammalian stem cells and at least one polysaccharide such as trehalose, and the like; a mammalian stem cell aggregation inhibitor containing polysaccharide such as trehalose, and the like; a method of suppressing aggregation of mammalian stem cells, containing suspending the mammalian stem cells in an aqueous physiological solution containing polysaccharide; an inhibitor of a decrease in the survival rate of mammalian stem cells containing polysaccharide such as trehalose and the like; a method of suppressing a decrease in the survival rate of mammalian stem cells, containing suspending the mammalian stem cells in an aqueous physiological solution containing polysaccharides, and the like.Type: GrantFiled: November 9, 2011Date of Patent: October 2, 2018Assignees: OTSUKA PHARMACEUTICAL FACTORY, INC., JICHI MEDICAL UNIVERSITYInventors: Eiji Kobayashi, Tamaki Wada, Yasutaka Fujita, Norihiro Yoshinaga, Masako Doi, Yasuhiro Fujimoto, Takumi Teratani
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Publication number: 20180016549Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: ApplicationFiled: July 17, 2017Publication date: January 18, 2018Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa OKAIRI, Masuhiro NISHIMURA, Tamaki WADA
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Patent number: 9765296Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: GrantFiled: September 3, 2014Date of Patent: September 19, 2017Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa Okairi, Masuhiro Nishimura, Tamaki Wada
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Patent number: 9583455Abstract: Reliability of a semiconductor device is improved. A semiconductor device has a base material of insulating material having a through hole, a terminal formed on a lower surface of the base material, and a semiconductor chip mounted on an upper surface of the base material in a face-up manner. The semiconductor device has a conductive member such as a wire, which electrically connects a pad of the semiconductor chip with an exposed surface of the terminal which is exposed from the through hole of the base material, and has a sealing body for sealing the conductive member, inside of the through hole of the base material, and the semiconductor chip. An anchor is provided in a region of the exposed surface of the terminal which is exposed from the through hole of the base material except for a joint portion joined with the conductive member.Type: GrantFiled: April 7, 2016Date of Patent: February 28, 2017Assignee: Renesas Electronics CorporationInventors: Kenji Oyachi, Tamaki Wada, Yuichi Morinaga
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Patent number: 9498500Abstract: Methods of washing adherent cells, capable of effectively suppressing cell death due to proteolytic enzyme treatment for detaching the adherent cell from a culture vessel and subsequent cell treatment; cell-washing solutions used for the washing method; methods of producing cell suspensions for transplantation using the cell-washing solution; and kits comprising the cell-washing solution. Trehalose or its derivative or a salt thereof is added to physiological aqueous solutions to prepare cell-washing solutions containing trehalose or its derivative or a salt thereof as an active ingredient. The cell-washing solutions can be used to wash adherent cells before detaching the adherent cells from a culture vessel by proteolytic enzyme treatment to suppress cell death due to the proteolytic enzyme treatment. The concentration of trehalose applied to the cell-washing solution may be a concentration capable of suppressing the cell death due to the proteolytic enzyme treatment, such as 0.1 to 20 (w/v) %.Type: GrantFiled: April 21, 2015Date of Patent: November 22, 2016Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Eiji Kobayashi, Tamaki Wada, Masako Doi
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Publication number: 20160293564Abstract: Reliability of a semiconductor device is improved. A semiconductor device has a base material of insulating material having a through hole, a terminal formed on a lower surface of the base material, and a semiconductor chip mounted on an upper surface of the base material in a face-up manner. The semiconductor device has a conductive member such as a wire, which electrically connects a pad of the semiconductor chip with an exposed surface of the terminal which is exposed from the through hole of the base material, and has a sealing body for sealing the conductive member, inside of the through hole of the base material, and the semiconductor chip. An anchor is provided in a region of the exposed surface of the terminal which is exposed from the through hole of the base material except for a joint portion joined with the conductive member.Type: ApplicationFiled: April 7, 2016Publication date: October 6, 2016Applicant: Renesas Electronics CorporationInventors: Kenji OYACHI, Tamaki WADA, Yuichi MORINAGA
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Publication number: 20160254780Abstract: A power conversion apparatus that is connected between a solar panel and a power system, in which the power conversion apparatus includes a power generating mode that converts a generated power of the solar panel into an alternating current power, and a snow melting mode that heats the solar panel by obtaining the power from the power system, and supplying the power to the solar panel, and at the time of the snow melting mode, the power conversion apparatus controls a voltage which is output to the solar panel such that a first current value being a value where a current that is supplied to the solar panel from the power conversion apparatus is smaller than an overcurrent level of the solar panel flows in a predetermined period.Type: ApplicationFiled: February 19, 2016Publication date: September 1, 2016Inventors: Tomomichi ITO, Hideaki KUNISADA, Kaoru SONOBE, Hirotaka NISHIZAWA, Yoshiro NAKAJIMA, Tamaki WADA
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Publication number: 20160215258Abstract: An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation.Type: ApplicationFiled: September 3, 2014Publication date: July 28, 2016Applicants: OTSUKA PHARMACEUTICAL FACTORY, INC., OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Risa OKAIRI, Masuhiro NISHIMURA, Tamaki WADA
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Patent number: 9337134Abstract: Reliability of a semiconductor device is improved. A semiconductor device has a base material comprised of insulating material having a through hole, a terminal formed on a lower surface of the base material, and a semiconductor chip mounted on an upper surface of the base material in a face-up manner. Further, the semiconductor device has a conductive member such as a wire, which electrically connects a pad of the semiconductor chip with an exposed surface of the terminal which is exposed from the through hole of the base material, and has a sealing body for sealing the conductive member, inside of the through hole of the base material, and the semiconductor chip. An anchor means is provided in a region of the exposed surface of the terminal which is exposed from the through hole of the base material except for a joint portion joined with the conductive member such as the wire.Type: GrantFiled: May 15, 2014Date of Patent: May 10, 2016Assignee: Renesas Electronics CorporationInventors: Kenji Oyachi, Tamaki Wada, Yuichi Morinaga
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Publication number: 20160120170Abstract: The problem of the present invention is to provide a method for preserving mammalian cells over a long period of time using a solution for cell transplantation, capable of effectively suppressing cell death when the mammalian cells have been preserved, and the solution for cell transplantation. The present invention is characterized in that mammalian cells are preserved in a physiological aqueous solution for cell transplantation, comprising 2.0 to 6.0% (w/v) of trehalose, a derivative thereof, or a salt of trehalose or the derivative (a trehalose) and 4.0 to 7.0% (w/v) of dextran, a derivative thereof, or a salt of dextran or the derivative (a dextran). The effects of a trehalose and a dextran contained in the physiological aqueous solution for cell transplantation can suppress a decrease in the cell survival rate when mammalian cells are preserved for a long period of time (at least 14 days).Type: ApplicationFiled: June 18, 2014Publication date: May 5, 2016Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Masuhiro NISHIMURA, Tamaki WADA, Chikage SHIRAKAWA, Masako DOI
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Publication number: 20150224145Abstract: Methods of washing adherent cells, capable of effectively suppressing cell death due to proteolytic enzyme treatment for detaching the adherent cell from a culture vessel and subsequent cell treatment; cell-washing solutions used for the washing method; methods of producing cell suspensions for transplantation using the cell-washing solution; and kits comprising the cell-washing solution. Trehalose or its derivative or a salt thereof is added to physiological aqueous solutions to prepare cell-washing solutions containing trehalose or its derivative or a salt thereof as an active ingredient. The cell-washing solutions can be used to wash adherent cells before detaching the adherent cells from a culture vessel by proteolytic enzyme treatment to suppress cell death due to the proteolytic enzyme treatment. The concentration of trehalose applied to the cell-washing solution may be a concentration capable of suppressing the cell death due to the proteolytic enzyme treatment, such as 0.1 to 20 (w/v) %.Type: ApplicationFiled: April 21, 2015Publication date: August 13, 2015Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Eiji KOBAYASHI, Tamaki Wada, Masako Doi
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Patent number: 9040300Abstract: Methods of washing adherent cells, capable of effectively suppressing cell death due to proteolytic enzyme treatment for detaching the adherent cell from a culture vessel and subsequent cell treatment; cell-washing solutions used for the washing method; methods of producing cell suspensions for transplantation using the cell-washing solution; and kits comprising the cell-washing solution. Trehalose or its derivative or a salt thereof is added to physiological aqueous solutions to prepare cell-washing solutions containing trehalose or its derivative or a salt thereof as an active ingredient. The cell-washing solutions can be used to wash adherent cells before detaching the adherent cells from a culture vessel by proteolytic enzyme treatment to suppress cell death due to the proteolytic enzyme treatment. The concentration of trehalose applied to the cell-washing solution may be a concentration capable of suppressing the cell death due to the proteolytic enzyme treatment, such as 0.1 to 20 (w/v) %.Type: GrantFiled: September 24, 2013Date of Patent: May 26, 2015Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Eiji Kobayashi, Tamaki Wada, Masako Doi