Patents by Inventor Tamara L. Troy
Tamara L. Troy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8825140Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: GrantFiled: February 15, 2012Date of Patent: September 2, 2014Assignee: Xenogen CorporationInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Publication number: 20120150026Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: ApplicationFiled: February 15, 2012Publication date: June 14, 2012Applicant: Xenogen CorporationInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Patent number: 8180435Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: GrantFiled: June 24, 2010Date of Patent: May 15, 2012Assignee: Xenogen CorporationInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Publication number: 20120041302Abstract: An imaging subject handling system includes multiple portable imaging subject cartridges that optionally compress and anesthetize living imaging subjects therein during imaging, multiple receiving bases installed within separate imaging systems that interface with the cartridges, and multiple gas delivery systems that deliver an anesthetic gas flow to an installed cartridge. The cartridges include a gas delivery interface that accepts the anesthetic gas flow and provides it to the imaging subject, and one or more walls, a bottom and a top defining a closed interior that retains the anesthetic gas therewithin while the cartridge is in transport between separate imaging systems. The walls, bottom and/or top can be optically transparent and radiolucent to facilitate imaging. The cartridge can include a locking mechanism, a nose cone for the imaging subject, and co-registration features located on outside surfaces to facilitate the merging of images within software from multiple separate imaging systems.Type: ApplicationFiled: August 16, 2010Publication date: February 16, 2012Applicant: CALIPER LIFE SCIENCES, INC.Inventors: David G. NILSON, Bradley W. RICE, Heng XU, Tamara L. TROY
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Publication number: 20100305453Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: ApplicationFiled: July 2, 2010Publication date: December 2, 2010Inventors: Eva M. SEVICK-MURACA, Tamara L. TROY, Jeffery S. REYNOLDS
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Publication number: 20100262019Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: ApplicationFiled: June 24, 2010Publication date: October 14, 2010Applicant: XENOGEN CORPORATIONInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Patent number: 7764986Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: GrantFiled: July 29, 2007Date of Patent: July 27, 2010Assignee: Xenogen CorporationInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Patent number: 7649185Abstract: Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partially resemble the optical behavior of mammalian tissue. The phantom device has many uses. One use of the phantom device permits testing of tomography software in the imaging system, such as software configured for 3D reconstruction of the fluorescent light source. Another use tests spectral unmixing software in the imaging system. The phantom device also allows a user to compare trans- and epi-fluorescent illumination imaging results.Type: GrantFiled: March 6, 2007Date of Patent: January 19, 2010Assignee: Xenogen CorporationInventors: Bradley W. Rice, David G. Nilson, Tamara L. Troy
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Patent number: 7629573Abstract: The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at least partially resemble the optical behavior of mammalian tissue. Imaging the light source or phantom device may incorporate known properties of the optically selective material. Testing methods described herein assess the performance of a low-level light imaging system (such as the software) by processing light output by the phantom device and comparing the output against known results. The assessment builds a digital representation of the light source or test device and compares one or more components of the digital representation against one or more known properties for the light source or the test device.Type: GrantFiled: November 24, 2004Date of Patent: December 8, 2009Assignee: Xenogen CorporationInventors: Bradley W. Rice, David G. Nilson, Normand P. Nantel, Tamara L. Troy
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Publication number: 20080175790Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: ApplicationFiled: December 13, 2007Publication date: July 24, 2008Applicant: The Texas A&M University SystemInventors: Eva M. Sevick-Muraca, Tamara L. Troy, Jeffery S. Reynolds
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Patent number: 7403812Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: GrantFiled: May 17, 2002Date of Patent: July 22, 2008Assignee: Xenogen CorporationInventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Patent number: 7328059Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: GrantFiled: May 30, 2001Date of Patent: February 5, 2008Assignee: The Texas A & M University SystemInventors: Eva Sevick-Muraca, Tamara L. Troy, Jeffery S. Reynolds
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Patent number: 6777240Abstract: The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;'s and &mgr;a. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body.Type: GrantFiled: September 11, 2002Date of Patent: August 17, 2004Assignee: Sensys Medical, Inc.Inventors: Kevin H. Hazen, James Matthew Welch, Stephen F. Malin, Timothy L. Ruchti, Alexander D. Lorenz, Tamara L. Troy, Suresh Thennadil, Thomas B. Blank
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Publication number: 20030113924Abstract: The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+ and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;′s and &mgr;a. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body.Type: ApplicationFiled: September 11, 2002Publication date: June 19, 2003Inventors: Kevin H. Hazen, James Matthew Welch, Stephen F. Malin, Timothy L. Ruchti, Alexander D. Lorenz, Tamara` L. Troy, Suresh Thennadil, Thomas B. Blank
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Publication number: 20030040664Abstract: A method of measuring in vivo skin tissue thickness employs noninvasive NIR absorbance spectra. Constituents of a tissue sample are characterized and quantified based on differing absorbance spectra and scattering properties, allowing thickness and chemical composition of layers to be estimated. Pathlength normalization reduces spectral interference in predicting analyte concentrations.Type: ApplicationFiled: August 1, 2002Publication date: February 27, 2003Inventors: Suresh Thennadil, Thomas B. Blank, Tamara L. Troy
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Publication number: 20030002028Abstract: A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.Type: ApplicationFiled: May 17, 2002Publication date: January 2, 2003Inventors: Bradley W. Rice, Daniel G. Stearns, Tamara L. Troy
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Patent number: 6475800Abstract: The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+ and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;ms and &mgr;ma. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body.Type: GrantFiled: February 10, 2000Date of Patent: November 5, 2002Assignee: Instrumentation Metrics, Inc.Inventors: Kevin H. Hazen, James Matthew Welch, Stephen F. Malin, Timothy L. Ruchti, Alexander D. Lorenz, Tamara L. Troy, Suresh Thennadil, Thomas B. Blank
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Publication number: 20020072677Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique consists of a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: ApplicationFiled: May 31, 2001Publication date: June 13, 2002Inventors: Eva Sevick-Muraca, Tamara L. Troy, Jeffery S. Reynolds
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Publication number: 20010041829Abstract: A method of measuring in vivo skin tissue thickness employs noninvasive NIR absorbance spectra. Constituents of a tissue sample are characterized and quantified based on differing absorbance spectra and scattering properties, allowing thickness and chemical composition of layers to be estimated. Pathlength normalization reduces spectral interference in predicting analyte concentrations.Type: ApplicationFiled: December 21, 2000Publication date: November 15, 2001Inventors: Suresh Thennadil, Thomas B. Blank, Tamara L. Troy