Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway, the compositions of these fusion proteins, as well as methods for producing and using the same.

Abstract: A single piece electrical connector for connecting two circuit elements incudes a housing and an interconnection member provided therein with an array of electrically conductive and elastic spring contact elements provided on the interconnection member to interconnect the two circuit elements electrically and mechanically in a stacked or coplanar configuration. In some embodiments, the single piece electrical connector connects to interconnection terminals of each circuit element by the application of a force normal to the surfaces of the circuit elements. In some embodiments, the housing of the connector is configured to apply and maintain the normal force between the elastic spring contact elements of the connector and the interconnection terminals of the circuit elements to form low resistance interconnections therebetween.

Abstract: An apparatus comprising an integrated circuit device comprising a fiducial area of a first layer, the fiducial area comprising a metal area and a metal free area; and a plurality of zones that are metal free in multiple layers adjacent to the first layer, wherein the zones are defined by a footprint based on the fiducial area of the first layer and a second fiducial area of a second integrated circuit device, the footprint comprising multiple slits.

Abstract: An apparatus comprising a first integrated circuit device, the first integrated circuit device comprising a first layer with an area comprising metallization and metal-free slits; and a fiducial in a second layer above the first layer, the fiducial formed over the area comprising the metallization and metal-free slits.

Abstract: A system captures and utilizes expert knowledge in artificial intelligence. The system includes a knowledge capture module for extracting expert knowledge from subject matter experts in a conversational format and a knowledge management module for cataloging and summarizing the extracted knowledge. The system also includes a digital subject matter expert (dSME) module for ingesting the cataloged knowledge and using it to guide users in building AI models. A chatbot interacts with a user and selects the appropriate dSME module that is relevant to the user request. The system attempts to answer the user request based on the dSME module. If the dSME module lacks knowledge to solve the problem, the system uses a set of tools, for example, internet based search engine to solve the problem.

Abstract: Ophthalmic formulations containing nintedanib, or a pharmaceutically acceptable salt thereof are provided. The ophthalmic formulations can contain microparticles or nanoparticles of nintedanib. Also provided are methods of using the ophthalmic formulations for treating ocular surface diseases, such as dry eye disease.

Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway, the compositions of these fusion proteins, as well as methods for producing and using the same.

Abstract: Pharmaceutical compositions containing AG-80308 and cyclodextrin are provided. Also provided are methods for treating ocular inflammatory diseases in a subject in need of such treatment by administering pharmaceutical compositions containing AG-80308 and cyclodextrin. Compositions may be formulated for ophthalmic application, for example, for ocular delivery, such as eye drops, to subjects in need thereof.

Abstract: Provided are methods and systems for traversing a data model with a plurality of workers to generate a plurality of virtual records for use in evaluating an expression by a plurality of aggregators. Each aggregator may receive a respective virtual record and evaluate a hypercube function and determine a respective hash based on the respective virtual record. The virtual records based on the respective hash values of the respective virtual records may be stored by the plurality of aggregators.

Abstract: In an aspect, provided is a method comprising receiving a data model, partitioning a first table in the data model into a first plurality of blocks of rows, generating a first plurality of indexlets, the first plurality of indexlets comprising a first plurality bidirectional indexes, each of the first plurality of bidirectional indexes being generated based on a corresponding one of the first plurality of blocks of rows.

Abstract: Implementing augmented reality to display recovery and/or security options on a private data-less card device (i.e., card device that does not include private data visible on a card facing) that has been misplaced. A card device includes a wireless communication mechanism that is configured to communicate card device and/or user-identifying data to a mobile communication device in possession of a user that includes an application configured to verify that the user is not a rightful possessor/owner of the card device based on the card device and/or user-identifying data. In response, the application launches the image capturing device on the mobile communication device and an image is captured of either the front facing or the back facing of the card device. Consequently, the application presents an augmented reality display that includes activatable links superimposed in augmented reality form on the captured image of either the front facing or the back facing of the card device.

Abstract: Implementing augmented reality to display recovery and/or security options on a private data-less card device (i.e., card device that does not include private data visible on a card facing) that has been misplaced. A card device includes a wireless communication mechanism that is configured to communicate card device and/or user-identifying data to a mobile communication device in possession of a user that includes an application configured to verify that the user is not a rightful possessor/owner of the card device based on the card device and/or user-identifying data. In response, the application launches the image capturing device on the mobile communication device and an image is captured of either the front facing or the back facing of the card device. Consequently, the application presents an augmented reality display that includes activatable links superimposed in augmented reality form on the captured image of either the front facing or the back facing of the card device.

Abstract: A private data-less card device that enables augmented reality display of the private data on the card device. Characteristic of the private data-less card neither the front nor back facings of the card device have any private data used to initiate a resource event physically displayed thereon. The card device includes a wireless communication mechanism configured to wirelessly communicate at least one of card device-identifying data and user-identifying data to a mobile communication device to enable an augmented reality display of the private data superimposed over an image of the facing of the card device.

Abstract: Augmented reality is implemented to display private data on a card device that does not include actual visible private data. The card device includes a wireless communication mechanism that is configured to communicate card device and/or user-identifying data to a mobile communication device in possession of a user. The mobile communication device includes an application that is configured to receive the card device and/or user-identifying data and verify that the user is a rightful possessor/owner of the card device. Once the user has been verified and, in some embodiments, authenticated, the application launches the image capturing device on the mobile communication device and an image is captured of either the front facing or the back facing of the card device. Consequently, the application presents an augmented reality display that includes the private data superimposed in augmented reality form on the captured image.

Abstract: In an aspect, provided is a method comprising receiving, at a master node, capability information associated with a plurality of worker nodes, receiving, at the master node, an indexation request, and in response to the indexation request, distributing one or more tasks to the plurality of worker nodes based on the respective capability information, wherein the one or more tasks relate to generating a plurality of indexlets.

Abstract: Provided are methods and systems for traversing a data model with a plurality of workers to generate a plurality of virtual records for use in evaluating an expression by a plurality of aggregators. Each aggregator may receive a respective virtual record and evaluate a hypercube function and determine a respective hash based on the respective virtual record. The virtual records based on the respective hash values of the respective virtual records may be stored by the plurality of aggregators.

Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway as well as formulation compositions of such fusion proteins, as well as methods for producing and using the same.

Abstract: Provided are methods and systems for traversing a data model with a plurality of workers to generate a plurality of virtual records for use in evaluating an expression by a plurality of aggregators. Each aggregator may receive a respective virtual record and evaluate a hypercube function and determine a respective hash based on the respective virtual record. The virtual records based on the respective hash values of the respective virtual records may be stored by the plurality of aggregators.

Abstract: In an aspect, provided is a method for targeted extraction of data satisfying a query. The method can rely upon one or more data structures indicative of data values satisfying or not satisfying one or more filters. Only the data indicated as satisfying (or as not satisfying) the data in a data structure related to the query are extracted. The extracted data may then be sorted.

Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway as well as formulation compositions of such fusion proteins, as well as methods for producing and using the same.