Abstract: Systems and methods for interpreting and visualizing multi-Z horizons from seismic data are disclosed. A two-dimensional (2D) representation of seismic data is displayed via a graphical user interface (GUI). User input is received via the GUI for interpreting a multi-Z horizon within a portion of the displayed 2D representation. The user's input is tracked relative to displayed 2D representation within the GUI. Based on the tracking, each of a plurality of surfaces for the multi-Z horizon is determined. At least one intersection point between the multi-Z horizon surfaces is identified. A depth position for each surface relative to other surfaces is determined. The 2D representation of the seismic data is dynamically updated to include visual indications for the plurality of surfaces and the intersection point(s), based on the depth position of each surface, where the visual indications use different visualization styles to represent the surfaces and intersection point(s).

Abstract: Disclosed are systems and methods for extracting and visualizing patterns in large-scale data sets. A data set comprising a plurality of data points is received. A plurality of connections between the plurality of data points is generated. Based on the plurality of connections, a plurality of groups from the plurality of data points is generated. A visual analytic comprising a plurality of geometrical shapes corresponding to the plurality of groups is generated.

Abstract: Ophthalmic formulations containing nintedanib, or a pharmaceutically acceptable salt thereof are provided. The ophthalmic formulations can contain microparticles or nanoparticles of nintedanib. Also provided are methods of using the ophthalmic formulations for treating ocular surface diseases, such as dry eye disease.

Abstract: A spectroscopic metrology system includes a spectroscopic metrology tool and a controller. The controller generates a model of a multilayer grating including two or more layers, the model including geometric parameters indicative of a geometry of a test layer of the multilayer grating and dispersion parameters indicative of a dispersion of the test layer. The controller further receives a spectroscopic signal of a fabricated multilayer grating corresponding to the modeled multilayer grating from the spectroscopic metrology tool. The controller further determines values of the one or more parameters of the modeled multilayer grating providing a simulated spectroscopic signal corresponding to the measured spectroscopic signal within a selected tolerance. The controller further predicts a bandgap of the test layer of the fabricated multilayer grating based on the determined values of the one or more parameters of the test layer of the fabricated structure.

Abstract: Ophthalmic formulations containing nintedanib, or a pharmaceutically acceptable salt thereof are provided. The ophthalmic formulations can contain microparticles or nanoparticles of nintedanib. Also provided are methods of using the ophthalmic formulations for treating ocular surface diseases, such as dry eye disease.

Abstract: In an aspect, provided is a method comprising receiving, at a master node, capability information associated with a plurality of worker nodes, receiving, at the master node, an indexation request, and in response to the indexation request, distributing one or more tasks to the plurality of worker nodes based on the respective capability information, wherein the one or more tasks relate to generating a plurality of indexlets.

Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway, the compositions of these fusion proteins, as well as methods for producing and using the same.

Abstract: Methods, systems and apparatus for detecting object location and generating alerts are disclosed herein. An example disclosed method includes determining an assigned area for an object being handled by a loader; detecting a first location of the loader; determining whether the first location corresponds to the assigned area for the object; and in response to the first location not corresponding to the assigned area for the object, generating a first output indicative of a difference between the first location and the assigned area for the object.

Abstract: In an aspect, provided is a method comprising receiving, at a master node, capability information associated with a plurality of worker nodes, receiving, at the master node, an indexation request, and in response to the indexation request, distributing one or more tasks to the plurality of worker nodes based on the respective capability information, wherein the one or more tasks relate to generating a plurality of indexlets.

Abstract: A prosthetic foot and method of fabricating the same is disclosed which includes a socket assembly configured to connect to a natural limb of a patient, a sideway cylindrical ankle joint having a maze-like internal structure laterally affixed to the socket assembly; a foot assembly, laterally affixed to the sideway cylindrical ankle joint, having a dorsal portion, a phalange portion, a sole portion, and a heel portion; the phalange portion having a first end connected to the dorsal portion and a second end connected to the sole portion, the sole portion having a curve shape and connected to the heel portion; and the heel portion having a spring assembly connected to said cylindrical ankle joint.

Abstract: Crystalline forms of free base 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and preparation methods thereof are provided; the pharmaceutical formulations containing the crystalline forms and their use in the treatment of diseases, particularly angiogenic eye diseases are also provided.

Abstract: A system for scanning and analyzing a device wider test includes a transducer. The transducer transmits ultrasonic waves to scan the device under test and determine various properties (e.g., material of layers). The system further includes a heating/cooling portion. The heating/cooling portion conducts thermal stress testing on the device under test to accentuate areas of delamination between layers. The transducer then performs scans on the device under test to locate areas of delamination.

Abstract: An intelligent sorting apparatus includes sensors, bins, and a controller that is configured to use data from the sensors to intelligently sort items into one of the plurality of bins. The controller may use the sensors to determine whether an item includes one of ceramic, metal, or wet or dry waste, as the item traverses down a first, second, and/or third incline, respectively. The controller may route the item towards one of a ceramic bin when the item includes ceramic, metal bin when the item includes metal, wet bin when the item includes wet waste, or dry bin when the item includes dry waste.

Abstract: An intelligent sorting apparatus includes sensors, bins, and a controller that is configured to use data from the sensors to intelligently sort items into one of the plurality of bins. The controller may use the sensors to determine whether an item includes one of ceramic, metal, or wet or dry waste, as the item traverses down a first, second, and/or third incline, respectively. The controller may route the item towards one of a ceramic bin when the item includes ceramic, metal bin when the item includes metal, wet bin when the item includes wet waste, or dry bin when the item includes dry waste.

Abstract: In an aspect, provided is a method for targeted extraction of data satisfying a query. The method can rely upon one or more data structures indicative of data values satisfying or not satisfying one or more filters. Only the data indicated as satisfying (or as not satisfying) the data in a data structure related to the query are extracted. The extracted data may then be sorted.

Abstract: Provided are methods and systems for traversing a data model with a plurality of workers to generate a plurality of virtual records for use in evaluating an expression by a plurality of aggregators. Each aggregator may receive a respective virtual record and evaluate a hypercube function and determine a respective hash based on the respective virtual record. The virtual records based on the respective hash values of the respective virtual records may be stored by the plurality of aggregators.

Abstract: The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway, the compositions of these fusion proteins, as well as methods for producing and using the same.

Abstract: Provided are methods and systems for improved data management, data analysis, and processing. A computing device may receive one or more global queries. Each of the global queries may be associated with one or more local components, such as individual nodes of a cloud network. The computing device may determine one or more indexlets associated with each local component. The computing device may then generate query results for the one or more global queries using a global query plan and the one or more indexlets.

Abstract: Crystalline forms of free base 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and preparation methods thereof are provided; the pharmaceutical formulations containing the crystalline forms and their use in the treatment of diseases, particularly angiogenic eye diseases are also provided.

Abstract: Methods, systems and apparatus for detecting object location and generating alerts are disclosed herein. An example disclosed method includes determining an assigned area for an object being handled by a loader; detecting a first location of the loader; determining whether the first location corresponds to the assigned area for the object; and in response to the first location not corresponding to the assigned area for the object, generating a first output indicative of a difference between the first location and the assigned area for the object.