Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

Abstract: A single-side tower-type roller system based asynchronous rolling mill for rolling an ultra-thin composite strip and a hydraulic system therefor are provided. The mill includes a machine frame and reel assemblies. An upper roller system assembly and a lower roller system assembly are arranged in the machine frame. A down-pressing assembly is arranged on the machine frame and used to adjust a roll gap between the upper roller system assembly and the lower roller system assembly. A support roller balance assembly is arranged on the machine frame and used to support and balance the upper roller system assembly. The lower roller system assembly includes right and left working rollers. The right working roller is a plain roller. The left working roller is a patterned roller. A left-pressing assembly is arranged on the machine frame and used to adjust a roll gap between the right and left working rollers.

Abstract: A structure and method for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area, belonging to the field of ecological restoration technologies. The structure for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area provided by the present invention includes an ecological water-harvesting pond, ecological intercepting ditches, an improved soil layer laid on the surface of a to-be-restored slope region and a soil restoration ecological network disposed on the improved soil layer. The improved soil layer, the ecological water-harvesting pond and the ecological intercepting ditches are each provided with a combined plant synusia system.

Abstract: A lubricant composition that comprises a hydrocarbon base oil, a polar viscosity improver; and an esterified polyalkylene glycol: R1[O(R2O)n(R3O)m(C?O)R4]p, wherein R1 is a linear alkyl having 1 to 18 carbon atoms, a branched alkyl having 4 to 18 carbon atoms or an aryl with 6 to 30 carbon atoms; R2O is an oxypropylene moiety derived from 1, 2-propylene oxide; R3O is an oxybutylene moiety derived from butylene oxide, wherein R2O and R3O are in a block or a random distribution; R4 is a linear alkyl with 1 to 18 carbon atoms, a branched alkyl with 4 to 18 carbon atoms or an aryl with 6 to 18 carbon atoms; n and m are each independently integers ranging from 0 to 20 wherein n+m is greater than 0, and p is an integer from 1 to 4. The lubricant composition may have a viscosity index of at least 150, a kinematic viscosity at 100° C. from 2 to 5 centistokes and a kinematic viscosity at ?20° C. of at most 600 centistokes.

Abstract: A hydraulically controlled backing roller includes a mandrel, two cover plates which are installed at two ends of the mandrel through screws respectively, and two screwdown gears which are installed at two end portions of the mandrel respectively. The two screwdown gears are engaged with an output rack of a screwdown hydraulic cylinder, multiple saddle ring sets are sleeved on the mandrel at equal intervals, a saddle ring of each of the saddle ring sets is fixed with a frame through a fan-shaped plate, a backing bearing is provided between two adjacent saddle ring sets; an inner eccentric ring of the each of the saddle ring sets is driven to rotate by hydraulic driving, so that the mandrel has a deflection deformation, and the deflection deformation is transmitted to other adjacent rollers through the backing bearing.

Abstract: The embodiments of the present disclosure provide a display substrate, a display device, and a detection method for the display substrate. The display substrate includes: a base substrate including a display region and a peripheral region located on at least one side of the display region; a crack stopper located in the peripheral region and configured to prevent a crack from propagating toward the display region; an encapsulation structure disposed on the base substrate and covering the display region; and a crack detection structure disposed on the base substrate, wherein the crack detection structure is located on a side of the crack stopper facing the display region, an orthographic projection of the crack detection structure on the base substrate falls within an orthographic projection of the encapsulation structure on the base substrate, and the crack detection structure is configured to detect whether a crack exists in the encapsulation structure.

Abstract: A reciprocating saw comprises a housing, a blade assembly, a reciprocating rod assembly, a driving assembly and an operation mechanism. The blade assembly extends forward from one side of the housing, and comprises a positioning structure. The reciprocating rod assembly is detachably connected with the blade assembly and comprises a blade fixing structure and an unlocking component matched with the positioning structures. The driving assembly is accommodated in the housing, and drives the reciprocating rod assembly to drive the blade assembly to perform reciprocating motion. The operation mechanism is installed on the housing and moves between a locking position and an unlocking position and comprises an operation button, a drive cam matched with the unlocking components and an elastic reset component for resetting the operation button.

Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: The invention relates to an air outlet structure, a column, and a vehicle. The air outlet structure comprises: an air duct; a first air outlet and a second air outlet, the first air outlet and the second air outlet being configured to be spaced apart from each other and parallel to each other; and a first air-inducing channel and a second air-inducing channel, the first air-inducing channel extending to the first air outlet from the air duct, the second air-inducing channel extending to the second air outlet from the air duct, and the first air-inducing channel and the second air-inducing channel being configured in such a manner that a first airflow flowing out of the first air outlet and a second airflow flowing out of the second air outlet intersect and scatter each other. Through the foregoing air outlet structure, the vehicle according to the invention can expand an air supply range, significantly improve uniformity of air supply, and prevent directly blowing air to a passenger.

Abstract: Apparatus and methods are related to treating waste water containing ammonium salts, which contains NH4+, SO42?, Cl?, and Na+. In such a method, the pH value of the waste water to be treated is adjusted to a specific range in advance; sodium sulfate crystal and relatively concentrated ammonia are obtained by first evaporation, and then sodium chloride crystal and relatively dilute ammonia is obtained by second evaporation; alternatively, sodium chloride crystal and relatively concentrated ammonia is obtained by third evaporation, and then sodium sulfate crystal and relatively dilute ammonia are obtained by fourth evaporation. Ammonia, sodium sulfate, and sodium chloride from the waste water are recovered so that the resources in the waste water can be reused.

Abstract: The present invention relates to a method for carbon dioxide capture and concentration by partitioned multistage circulation based on mass transfer-reaction regulation. In the present invention, multiple means such as multistage circulating absorption, intelligent multi-factor regulation, pre-washing and cooling, inter-stage cooling, post-stage washing, slurry cleaning, cooling water waste heat utilization, small-particle-size and high-density spraying, external strengthening field such as a thermal field/ultrasonic field/electric field, and catalysis by composite catalyst are adopted, so that the target for low cost, low energy consumption, stability and high efficiency is realized. The secondary pollutants are effectively inhibited while carbon dioxide is efficiently captured; meanwhile, high-efficiency capture, low-energy desorption, and high-purity concentration of carbon dioxide are implemented.

Abstract: This application discloses a method and an apparatus for selecting a face image, a device, and a storage medium and relates to the field of artificial intelligence technologies. The method includes detecting, after a frame of face image is obtained, whether the face image meets a preliminary quality screening condition; determining, in response to a first face image meeting the preliminary quality screening condition, an overall quality score of the first face image, the overall quality score representing overall quality of the face image; and transmitting the first face image to a face recognition process in response to the overall quality score of the first face image being greater than a level-one threshold.

Abstract: A 660MW supercritical unit bypass control method after a load rejection is provided. Steam channels after the load rejection are switched without an interference, and ache steam pressure is controllable. The 660MW supercritical unit bypass control method includes Pipeline 1, Pipeline 2, Pipeline 3, and Pipeline 4; a bottom of Pipeline 3, a bottom of the Pipeline 2, and a head of the Pipeline 4 are connected by a temperature and pressure reducer; a bottom of the Pipeline 1 is connected to a head of Pipeline 2; a branch pipe is arranged between the Pipeline 1 and the Pipeline 2, and a steam turbine is arranged in the branch pipe. A high-pressure bypass control system automatically adapts to the load rejection or FCB under any loading situation, avoids drastic changes of unit parameters from loading fluctuations, meets requirements of the load rejection and the FCB.

Abstract: The present disclosure provides A lubricant composition comprises an antioxidant; and an esterified polyalkylene glycol: R1[O(R2O)n(R3O)m(C?O)R4]p, wherein R1 is a linear alkyl having 1 to 18 carbon atoms, a branched alkyl having 4 to 18 carbon atoms or an aryl with 6 to 30 carbon atoms; R2O is an oxypropylene moiety derived from 1,2-propylene oxide; R3O is an oxybutylene moiety derived from butylene oxide, wherein R2O and R3O are in a block or a random distribution; R4 is a linear alkyl with 1 to 18 carbon atoms, a branched alkyl with 4 to 18 carbon atoms or an aryl with 6 to 18 carbon atoms; n and m are each independently integers ranging from 0 to 20 wherein n+m is greater than 0, and p is an integer from 1 to 4, wherein the antioxidant is present in an amount by weight of at least 0.5% to 20% based upon the weight of the antioxidant and the esterified polyalkylene glycol and the antioxidant is soluble in the esterified polyalkylene glycol in an amount of at least 0.5% by weight.

Abstract: The embodiment of the present disclosure provides a display panel and a manufacturing method thereof. The display panel includes: an active area; and an aperture area at least partially surrounded by the active area, wherein at least one barrier wall is provided between the active area and the aperture area, a thin film encapsulation is provided on a first side of the display panel, and the thin film encapsulation covers the barrier wall and the active area, and wherein a convex-concave structure is provided on at least one surface of the barrier wall in contact with the thin film encapsulation.

Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

Abstract: The disclosure relates to a display panel, a method for fabricating the same, and a display device. The display panel includes: a base substrate including a first base substrate in a blind hole area and a second base substrate, the thickness of the first base substrate is smaller than the thickness of the second base substrate; an anode layer, a light-emitting layer, a cathode layer and an encapsulation layer arranged successively on the second base substrate, and the cathode layer and the encapsulation layer arranged successively on the first base substrate; wherein at least one installation hole is arranged in a display area of the display panel, the at least one installation hole is within the blind hole area and runs through the first base substrate and the respective layers on the first base substrate.