Patents by Inventor Tao Xin

Tao Xin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015204
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015234
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Azaindoles Having Serotonin Receptor Affinity
    Publication number: 20080004307
    Abstract: Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein A, B, D, E, R1 to R3 and n are described herein. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
    Type: Application
    Filed: August 7, 2007
    Publication date: January 3, 2008
    Applicant: NPS Allelix Corp.
    Inventors: Louise Edwards, Abdelmalik Slassi, Ashok Tehim, Tao Xin
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20070293545
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: December 20, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS
    Publication number: 20070270468
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 22, 2007
    Inventors: Alexander MINIDIS, David WENSBO, Methvin ISAAC, Abdelmalik SLASSI, Jalaj ARORA, Tao XIN, Louise EDWARDS, Caroline ERIKSSON, Veronica PROFIR, Per-Olov BERGSTROM
  • NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS
    Publication number: 20070270469
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 22, 2007
    Inventors: Alexander MINIDIS, David WENSBO, Methvin ISAAC, Abdelmalik SLASSI, Jalaj ARORA, Tao XIN, Louise Edwards, Caroline ERIKSSON, Veronica PROFIR, Per-Olov BERGSTROM
  • MGluR5 modulators IV
    Publication number: 20070259923
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Andreas Wallberg, Tomislav Stefanac
  • mGluR5 modulators III
    Publication number: 20070259926
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Tomislav Stefanac
  • MGluR5 modulators I
    Publication number: 20070259862
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Andreas Wallberg, Karolina Nilsson, Bjorn Holm, Mats Nagard, Kenneth Granberg, Abdelmalik Slassi, Louise Edwards, Methvin Isaac, Tao Xin, Tomislav Stefanac
  • MGluR5 modulators V
    Publication number: 20070259860
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Andreas Wallberg, Karolina Nilsson, Kenneth Granberg, Saswati Ghosal, Abdelmalik Slassi, Louise Edwards, Methvin Isaac, Tao Xin, Tomislav Stefanac, Peter Dove
  • mGluR5 modulators II
    Publication number: 20070259916
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Tomislav Stefanac
  • MGluR5 modulators VI
    Publication number: 20070259895
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Tomislav Stefanac, Peter Dove, Mats Nagard
  • 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5
    Publication number: 20070255061
    Abstract: The present invention relates to new compounds of formula I, wherein Z, Q, X1, X2, R1 and R2, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: December 13, 2004
    Publication date: November 1, 2007
    Applicants: AstraZeneca AB, NPS Pharmaceuticals, Inc.
    Inventors: David Wensbo, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tao Xin, Thomas Stormann
  • Azaindoles having serotonin receptor affinity
    Patent number: 7268127
    Abstract: Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: Wherein A, B, D, E, R1 to R3 and n are described herein. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: September 11, 2007
    Assignee: NPS Allelix Corp
    Inventors: Louise Edwards, Abdelmalik Slassi, Ashok Tehim, Tao Xin
  • Tetrazole compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070197549
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 23, 2007
    Applicant: AstraZeneca AB
    Inventors: Martin Johansson, Alexander Minidis, Karin Staaf, David Wensbo, Donald McLeod, Louise Edwards, Methvin Isaac, Anne O'Brien, Abdelmalik Slassi, Tao Xin, Tomislav Stefanac
  • Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185095
    Abstract: The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Martin Johansson, David Wensbo, Alexander Minidis, Karin Staaf, Annika Kers, Louise Edwards, Methvin Isaac, Tomislav Stefanac, Abdelmalik Slassi, Donald McLeod, Tao Xin
  • Triazole compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185178
    Abstract: The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy, especially for the treatment of mGluR5 receptor mediated disorders, and for the treatment of neurological disorders, psychiatric disorders, gastrointestinal disorders and pain disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicants: AatraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Johan Malmberg, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, David Wensbo, Tao Xin, Tomislav Stefanac
  • Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185100
    Abstract: The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicant: AstraZeneca AB
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Annika Kers, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, David Wensbo, Tao Xin, Bjorn Holm
  • Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070179188
    Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: February 15, 2005
    Publication date: August 2, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald Mcleod, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • New compounds for the treatment of neurological, psychiatric or pain disorders
    Publication number: 20070129408
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: September 20, 2006
    Publication date: June 7, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Alexander Minidis, David Wensbo, Methvin Isaac, Abdelmalik Slassi, Jalaj Arora, Tao Xin, Louise Edwards, Caroline Eriksson, Veronica Profir, Per-Olov Bergstrom