Abstract: A system for reconstructing a magnetic particle image based on adaptive optimization of regularization terms includes: a MPI device for scanning an imaging object to acquire a voltage response signal; a signal processor for constructing a system matrix; and a control processor for reconstructing the magnetic particle image based on an arbitrarily selected regularization term, inputting the reconstructed magnetic particle image to a regularization-term adaptive optimization neural network model for enhancement processing, taking the enhanced magnetic particle image as a first image, and calculating a loss value between the first image and an initial image to acquire a final reconstructed magnetic particle image. The system adopts a neural network model-based automatic learning approach, instead of the approach of manually selecting regularization terms and adjusting parameters, to improve the reconstruction efficiency and quality of the magnetic particle image.

Abstract: The present application relates to the technology field of assessment of aging state of oil paper insulation of the large power transformer and quantitative diagnostic, specifically estimating parameters of the circuit through the initial slope of the recovery voltage. It includes an improved mathematical model for solving parameters of the dielectric response equivalent circuit by using the peak of the recovery voltage, the peak time and the initial slope characteristics; transforming the identification of parameters of the equivalent circuit into a mathematical optimization problem, and then solving the mathematical optimization problem using a particle swarm algorithm. The design of the present application can significantly reduce the sampling data of the recovery voltage, and the measured data in the field and the calculated data of different capacity RVM experiments on real transformers have good consistency, which is conducive to the diagnosis of state of oil paper insulation of the transformer.

Abstract: Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

Abstract: A light emitting diode epitaxial structure and a light emitting diode are provided. The light emitting diode epitaxial structure includes a substrate, and an N-type semiconductor layer, an intermediate layer, a multi-quantum well layer and a P-type semiconductor layer which are sequentially arranged on the substrate, wherein the intermediate layer is doped with a n-type impurity, and a doping concentration of the n-type impurity is ?4×1018 atoms/cm3. In a specific implementation of the present disclosure, the n-type impurity is Si, and the intermediate layer is a GaN layer doped with Si.

Abstract: The present disclosure discloses sulfonamides, methods for preparation thereof and uses thereof, belonging to the technical field of medicinal chemistry. The structure of the sulfonamides of the present disclosure is shown in Formula I. The present disclosure also provides use of the compound of Formula I or a salt, solvate, isomer, metabolite, nitrogen-oxide, or prodrug thereof in the manufacture of a medicament for the treatment or prevention of P2X3 and/or P2X2/3 receptor-associated diseases. The sulfonamides of the present disclosure have a potent cough suppressing effect and a significantly prolonged action. Their inhibitory activity against P2X3 is superior to that of Comparative compound 1 and the positive control Gefapixant.

Abstract: A pharmaceutical salt of Fingolimod, preparation method, pharmaceutical composition and use thereof are provided. The pharmaceutical salt of Fingolimod of formula I is a salt formed from a Fingolimod free base and an organic acid having at least six carbon atoms. The pharmaceutical salt of Fingolimod has better solubility and stability, and a good market prospect.

Abstract: The present disclosure provides an intelligent hair dryer, including: an airflow detection channel, a sensor, a control system, and a main air duct. The airflow detection channel is arranged on at least one side of the main air duct, and an air inlet of the airflow detection channel opens towards a blowing direction of the main air duct of the intelligent hair dryer. The sensor is arranged in the airflow detection channel, and is configured to detect state information of airflow having touched a blown object. The control system may control operation state of the intelligent hair dryer by using the state information of the airflow. By using the intelligent hair dryer of the present disclosure, it can ensure that a user is saved from the trouble of repeatedly adjusting the gear position of the hair dryer during use.

Abstract: A plurality of pieces of to-be-processed data are obtained, and a plurality of groups corresponding to the plurality of pieces of to-be-processed data are further obtained. Watermarks are added to to-be-processed data in the target group by using the target group as a granularity. Because watermarks are added to the plurality of pieces of to-be-processed data by using the group as the granularity, although the to-be-processed data in the group is modified due to watermark adding, the to-be-processed data changes within a range of a small amount of to-be-processed data included in the target group, and does not change within a range of the to-be-processed data, thereby alleviating a problem that the data is severely distorted after watermark adding. When to-be-processed data with similar semantics is placed in a same group, semantics of the to-be-processed data in the target group has a relatively small change after watermark adding.

Abstract: The present disclosure discloses a method for reminding a replacement of a filter of a vacuum cleaner, including: obtaining a rotating speed difference of a motor within a set time interval; comparing, according to a working parameter of the vacuum cleaner, the rotating speed difference with a preset rotating speed difference threshold, to obtain a comparison result; and determining whether to remind a user to replace the filter according to the comparison result. With the method provided by the present disclosure, the vacuum cleaner may timely and automatically remind the user to replace the filter during the use of the vacuum cleaner, thereby reducing power loss, maintaining the normal use of the vacuum cleaner, and prolonging the service life of the motor.

Abstract: Provided is a fusion protein of human serum albumin or a wild type thereof and human interleukin-2 or a mutation thereof, said fusion protein has a significantly extended in vivo half-life relative to recombinant interleukin-2, can be used alone for treating a tumor, and improves anti-tumor efficacy of an anti-PD-1 antibody or an anti PD-L1-antibody.

Abstract: Crystalline forms of ACP-196, preparation methods, pharmaceutical compositions and uses thereof in the preparation of drugs for treatment and/or prevention of Bruton's tyrosine kinase (BTK)-mediated disorders such as autoimmune diseases or disorders, heteroimmune diseases or disorders, cancers including lymphoma and inflammatory diseases or disorders. As compared with the known solid form of ACP-196, the crystalline forms of the present invention have advantages in crystallinity.

Abstract: A pharmaceutical composition containing cariprazine, a preparation method and an application thereof are provided. The pharmaceutical composition contains cariprazine pamoate solid particles. A particle size of the cariprazine solid particles has a Dv(10) less than or equal to 30 microns, a Dv(50) less than or equal to 50 microns, and a Dv(90) less than or equal to 100 microns. When being used, the pharmaceutical composition containing cariprazine is an aqueous suspension and, the concentration of the free base of cariprazine is moderate. A long-term effect can be achieved upon injection of a certain administration volume of the pharmaceutical composition, thereby reducing the frequency of medication while increasing patient medication compliance. Furthermore, the pharmaceutical composition has a high bioavailability and has promising marketing prospects.

Abstract: A pharmaceutically acceptable salt of cariprazine, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof are provided. The pharmaceutically acceptable salt of cariprazine is a salt formed from the free base of cariprazine and an organic acid having six or more carbon atoms, and has relatively good solubility and stability.

Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.

Abstract: Provided is a method for preparing an adenovirus vector vaccine by means of a perfusion culture process. The method comprises a step of culturing adenovirus host cells, and in particular a step of adjusting the perfusion rate by means of at least two stages according to cell density. The method increases the single cell yield of a virus after infection and the specific activity of a virus harvest liquid while achieving high-density growth of adenovirus host cells.

Abstract: Provided are an mRNA or an mRNA composition, and an mRNA vaccine comprising the mRNA or the mRNA composition. The mRNA or the mRNA composition comprises an mRNA sequence encoding an S protein of a novel coronavirus SARS-CoV-2 or a variant thereof, and an mRNA sequence encoding an RBD in the S protein or a variant thereof. Further provided are the applications of the mRNA or the mRNA composition, and the mRNA vaccine comprising the mRNA or the mRNA composition in preparation of a medication for preventing and/or treating a disease caused by a novel coronavirus SARS-CoV-2 infection.

Abstract: An on-chip ultra-narrow linewidth laser and a method for obtaining a single-longitudinal mode ultra-narrow linewidth optical signal are provided in the present invention.

Abstract: Provided is a determination method of differential protection suitable for an electricity transmission line with multi-terminal T-connection.