Patents by Inventor Tatiana Novobrantseva

Tatiana Novobrantseva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene
    Patent number: 9868950
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: January 16, 2018
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Gregory Hinkle
  • METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND B7-H4
    Publication number: 20170334999
    Abstract: Provided herein are embodiments relating to therapeutic applications of B7-H4 antibodies.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 23, 2017
    Inventors: Sriram Sathyanarayanan, Tatiana Novobrantseva, Virna Cortez-Retamozo
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE
    Publication number: 20170067060
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
    Type: Application
    Filed: July 18, 2016
    Publication date: March 9, 2017
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin DeFougerolles, Tatiana Novobrantseva, Brian Bettencourt
  • SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS
    Publication number: 20160274089
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: October 30, 2015
    Publication date: September 22, 2016
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
    Publication number: 20160264972
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: October 13, 2015
    Publication date: September 15, 2016
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of CD274/PD-L1 gene
    Patent number: 9422562
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: August 23, 2016
    Assignee: Alnylam Pharmaceuticals
    Inventors: Antonin DeFougerolles, Tatiana Novobrantseva, Brian Bettencourt
  • ANTIBODIES THAT INHIBIT TIM-3:LILRB2 INTERACTIONS AND USES THEREOF
    Publication number: 20160200815
    Abstract: Provided herein are embodiments relating to therapeutic applications of antibodies that modulate; e.g., inhibit the interaction of TIM-3 and LILRB2 antibodies. In some embodiments, the antibodies bind TIM-3. In some embodiments the antibodies bind LILRB2. Modulation of the interaction of TIM-3 and LILRB2 stimulates the release of pro-inflammatory cytokines; e.g., myeloid-associated pro-inflammatory cytokines.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 14, 2016
    Inventors: Igor FELDMAN, Tatiana NOVOBRANTSEVA, Jamie WONG, Ryan PHENNICIE, Stephen Sazinsky, Sriram Sathyanarayanan
  • Lipid Formulated Compositions and Methods for Inhibiting Expression of Serum Amyloid A Gene
    Publication number: 20160194633
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA
    Type: Application
    Filed: November 4, 2015
    Publication date: July 7, 2016
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Gregory Hinkle
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENE
    Publication number: 20160017336
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
    Type: Application
    Filed: May 28, 2015
    Publication date: January 21, 2016
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Akin Akinc
  • Lipid Formulated Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
    Publication number: 20150353934
    Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: April 13, 2015
    Publication date: December 10, 2015
    Inventors: Antonin de Fougerolles, Anna Borodovsky, Tatiana Novobrantseva
  • Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene
    Patent number: 9206421
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: December 8, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Gregory Hinkle
  • Compositions and methods for inhibiting expression of a gene from the Ebola virus
    Patent number: 9187516
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: November 17, 2015
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America, as Represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
    Patent number: 9127275
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the KLF1 gene and the BCL11A gene, and methods of using such dsRNA compositions to inhibit expression of KLF1 and BCL11 A, respectively.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 8, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Tatiana Novobrantseva, Brian Bettencourt, Stuart Milstein, Anna Borodovsky
  • Compositions and methods for inhibiting expression of factor VII gene
    Patent number: 9062310
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: June 23, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Akin Akinc
  • Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
    Patent number: 9029338
    Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: May 12, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Anna Borodovsky, Tatiana Novobrantseva
  • Compositions And Methods For Inhibiting Expression Of CD45 Gene
    Publication number: 20150093417
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Antonin de Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lynn Warfield
  • Compositions and methods for inhibiting expression of CD45 gene
    Patent number: 8912316
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: December 16, 2014
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America as represented by the Army
    Inventors: Antonin De Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lyn Warfield
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENE
    Publication number: 20140343122
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
    Type: Application
    Filed: January 15, 2014
    Publication date: November 20, 2014
    Applicant: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Akin Akinc
  • Method of treating lung fibrosis using ST2 polypeptide
    Patent number: 8865645
    Abstract: Methods and compositions for treating fibrosis are disclosed.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: October 21, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Aldo Amatucci, Tatiana Novobrantseva, Alexander Ibraghimov, Alan Gill
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20140295449
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: October 21, 2013
    Publication date: October 2, 2014
    Applicant: Tekmira Pharmaceuticals, Inc.
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Home, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis