Patents by Inventor Tatiana Novobrantseva

Tatiana Novobrantseva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of influenza gene expression
    Patent number: 8227188
    Abstract: The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: July 24, 2012
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Pamela Tan, Anke Geicke, Rachel Meyers
  • Lipid Formulated Compositions and Methods for Inhibiting Expression of Serum Amyloid A Gene
    Publication number: 20110263684
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.
    Type: Application
    Filed: September 25, 2009
    Publication date: October 27, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Gregory Hinkle
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE
    Publication number: 20110251259
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
    Type: Application
    Filed: April 6, 2011
    Publication date: October 13, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin DeFougerolles, Tatiana Novobrantseva, Brian Bettencourt
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
    Publication number: 20110201671
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) FOR INHIBITING THE expression of a gene from the Ebola virus.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of a gene from the ebola virus
    Patent number: 7973020
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: July 5, 2011
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America as represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20110097720
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: December 31, 2008
    Publication date: April 28, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, De Fougerolles Antonin, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
    Publication number: 20110060031
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: May 27, 2010
    Publication date: March 10, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • LIVER SCREENING METHOD
    Publication number: 20110045473
    Abstract: The invention features a method of identifying therapeutically relevant compositions that include a therapeutic agent and a delivery component by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: December 31, 2008
    Publication date: February 24, 2011
    Inventors: Antonin De Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD45 GENE
    Publication number: 20110034537
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Application
    Filed: February 12, 2009
    Publication date: February 10, 2011
    Inventors: Antonin De Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lyn Warfield
  • RNAi INHIBITION OF INFLUENZA VIRUS REPLICATION
    Publication number: 20110033859
    Abstract: The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
    Type: Application
    Filed: September 3, 2010
    Publication date: February 10, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Pamela Tan, Anke Geick, Rachel Meyers
  • Compositions and methods for inhibiting expression of factor VII gene
    Patent number: 7871985
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: January 18, 2011
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Tatiana Novobrantseva, Akin Akinc
  • Methods for Use with Baff Antagonists
    Publication number: 20100330066
    Abstract: BAFF plays a central role in acquired immunity. The disclosure identifies BAFF-responsive genes that are substantially upregulated by administration of BAFF and substantially downregulated by treatment with a BAFF antagonist. Specific genes are: NF-?B2, CD23, H2-M? (the beta chain of H2-DM), Fig-1, and OBF-1. The disclosure provides methods and compositions for: monitoring the activity of a BAFF antagonist in a mammal; monitoring BAFF activity in a mammal; identifying a mammal to be treated with a BAFF antagonist; and related uses. Such methods include detecting one or more molecules selected from the group consisting of Fig-1 molecule, OBF-1 molecule, and H2-M? molecule in a biological sample of the mammal, and optionally further detecting NF-?B2 molecule and/or CD23 molecule in the biological sample.
    Type: Application
    Filed: October 12, 2006
    Publication date: December 30, 2010
    Inventors: Yen-Ming Hsu, Leonid Gorelik, Tatiana Novobrantseva, Joanne Quan, Flavius Martin, Susan L. Kalled
  • METHODS OF DELIVERING OLIGONUCLEOTIDES TO IMMUNE CELLS
    Publication number: 20100285112
    Abstract: The invention relates to the field of delivery of nucleic acid-based agents to immune cells.
    Type: Application
    Filed: May 5, 2010
    Publication date: November 11, 2010
    Inventors: Tatiana Novobrantseva, Akin Akinc, Tsukasa Sugo
  • LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
    Publication number: 20100267806
    Abstract: This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a lipid formulation, and methods of using the compositions to inhibit the expression of the Human kinesin family member 11 (Eg5) and Vascular Endothelial Growth Factor (VEGF), and methods of using the compositions to treat pathological processes mediated by Eg5 and VEGF expression, such as cancer.
    Type: Application
    Filed: March 12, 2010
    Publication date: October 21, 2010
    Inventors: David Bumcrot, Akin Akinc, Dinah Wen-Yee Sah, Tatiana Novobrantseva
  • Compositions and methods for inhibiting expression of a gene from the Ebola
    Patent number: 7759320
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: July 20, 2010
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • METHODS OF TREATING FIBROSIS
    Publication number: 20090304699
    Abstract: Methods and compositions for treating fibrosis are disclosed.
    Type: Application
    Filed: May 23, 2007
    Publication date: December 10, 2009
    Applicant: Biogen Idec MA Inc.
    Inventors: Aldo Amatucci, Tatiana Novobrantseva, Alexander Ibraghimov, Alan Gill
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE EBOLA
    Publication number: 20090143323
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: March 25, 2008
    Publication date: June 4, 2009
    Applicants: ALNYLAM PHARMACEUTICALS, INC., GOVERNMENT OF THE UNITED STATES
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • RNAI INHIBITION OF INFLUENZA VIRUS REPLICATION
    Publication number: 20070197460
    Abstract: The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
    Type: Application
    Filed: November 1, 2006
    Publication date: August 23, 2007
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin Fougerolles, Tatiana Novobrantseva, Pamela Tan, Anke Geick, Rachel Meyers
  • Methods for treating fibrotic conditions
    Publication number: 20070009518
    Abstract: The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens (e.g., antibodies against CD20), and BAFF antagonists.
    Type: Application
    Filed: May 18, 2006
    Publication date: January 11, 2007
    Applicant: Biogen Idec Inc.
    Inventors: Tatiana Novobrantseva, Shelia Violette, Victor Kotelianski, Alexander Ibraghimov