Abstract: The present disclosure relates to a radio transmission or reception apparatus and a beam forming method thereof. The apparatus according to the present disclosure comprises: an array antenna for forming multiple beams having different directivities so as to transmit or receive signals through the multiple beams; a digital unit for synthesizing an orthogonal polarization pair so as to generate multi-beam signals for forming the multiple beams; and an RF unit for frequency-converting the multi-beam signals so as to output each of the frequency converted multi-beam signals to the array antenna.

Abstract: The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.

Abstract: The present invention relates to an isolated antibody which specifically binds human PDL1, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.

Abstract: A method for identifying at least one RNA fragment comprising a 3? phosphate or 2?/3? cyclic phosphate as a molecular marker of a disease contained in a biological sample of a subject suffering from the disease and a kit for implementing the method.

Abstract: An in vitro or ex vivo method of diagnosis, prognosis, therapy monitoring or outcome prediction assessment of a disease or condition in a subject by detecting and quantifying at least one molecular marker of the disease or condition contained in a biological sample of the subject, wherein the at least one molecular marker is an RNA fragment comprising a 3? phosphate or a 2?/3? cyclic phosphate and kit for diagnosing Spinal Muscular Atrophy and cutaneous Squamous Cell Carcinoma.

Abstract: The present invention relates to antibody molecules and functional fragments thereof, capable of binding to tumor necrosis factor alpha (TNF?), to processes for their production, and to their therapeutic uses.

Abstract: The present invention relates to an isolated antibody which specifically binds human CD137, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid comprising a nucleotide sequence encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.

Abstract: The present invention relates to a multispecific antibody comprising at least one CD137 binding domain and at least one PDL1 binding domain, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid encoding said multispecific antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said multispecific antibody.

Abstract: Proposed is a method of recovering acids and alkalis from raffinate generated from a metal extraction process. The method includes pretreating raffinate generated from a metal extraction process and performing electrodialysis of the pretreated raffinate. The method recovers some components present in raffinate generated from a battery manufacturing process and a battery treatment process to reuse the recovered components. Therefore, the method provides economic and environmental benefits.

Abstract: In some examples, a semiconductor package comprises a die pad, a semiconductor die on the die pad, and a mold compound covering the die pad and the semiconductor die. The semiconductor package includes a conductive component including a roughened surface, the roughened surface having a roughness ranging from an arithmetic mean surface height (SA) of 1.4 to 3.2. The mold compound is coupled to the roughened surface. The semiconductor package includes a bond wire coupling the semiconductor die to the roughened surface. The bond wire is directly coupled to the roughened surface without a precious metal positioned therebetween.

Abstract: The present invention relates to a multispecific antibody comprising one or two binding domains, which specifically bind to the extracellular domain of ROR1 (ROR1-BDs), and one binding domain, which specifically binds to CD3 (CD3-BD), wherein the multispecific antibody does not comprise an immunoglobulin Fc region. The present invention further relates to nucleic acids encoding said multispecific antibody, vector(s) comprising said nucleic acids, host cell(s) comprising said nucleic acids or said vector(s), and a method of producing said multispecific antibody. Additionally, the present invention relates to pharmaceutical compositions comprising said multispecific antibody and methods of use thereof.

Abstract: Proposed are a coating resin composition for a flexible cover window and a flexible cover window formed using the same composition. The coating resin composition, includes, relative to the total weight thereof, 10 to 150 parts by weight of a urethane (meth)acrylate-based oligomer prepared by synthesizing an acrylic monomer containing a hydroxyl group with a urethane prepolymer synthesized from an ether-based polyol, diisocyanate, and polyoxyalkylene-based bisphenol ether, 1 to 60 parts by weight of a first photocurable acrylate-based monomer, 0.5 to 10 parts by weight of a second photocurable acrylate-based monomer, 0.5 to 10 parts by weight of an alkoxy silane coupling agent, 0.1 to 5 parts by weight of a siloxane additive, and to 20 parts by weight of a photopolymerization initiator.

Abstract: The present disclosure relates to kits, compositions and methods for detecting fungal species, viruses and/or protein variants in a sample, e.g., a biological sample. For example, but not by way of limitation, the present disclosure provides living yeast biosensors that have been genetically engineered to detect fungal species, viruses and/or protein variants in a sample, e.g., a biological sample.

Abstract: Proposed is a flexible cover window manufacturing method capable of simultaneously reinforcing a plane part and a folding part by using alkali-based metal ions having an ionic radius smaller than that of alkali-based metal ions contained in a glass. A flexible cover window manufactured using the same method is also proposed. The plane part and the folding part are simultaneously reinforced using alkali-based metal ions having a smaller ionic radius than alkali-based metal ions included in a glass to simplify the process, and the flexible cover window ensures strength and folding characteristics by controlling tensile stress of the entire part of the flexible cover window.

Abstract: Compounds and pharmaceutical compositions for use in the treatment of a disorder or disease mediated by the mTOR pathway through more selective binding to FKBP12 of the group of FK506 binding proteins (FKBPs) are disclosed. With an unusual pharmacokinetic profile and an enhanced pharmacodynamic selectivity among target FKBPs, those compounds are useful for the treatment of age- or aging-related diseases, diabetes, cancers, as well as inflammation-associated disorders.

Abstract: Systems and methods for an ultrasound scanner with an impact-resistance system are described. In some implementations, the impact-resistance system reduces acceleration components associated with an impact force applied to an enclosure of the ultrasound scanner or directly to an acoustic lens of a transducer array of the ultrasound scanner. The impact-resistance system distributes the acceleration components from the transducer array to the enclosure via couplings with soft and elastic materials. Some of the couplings may be located between the enclosure and elongated members embedded in backing material of the transducer array. Some of the couplings may be located between the enclosure and a flange that extends from the acoustic lens into a channel in the enclosure. Implementing the impact-resistance system described herein improves reliability of the transducer array without sacrificing performance or usability, particularly for ultraportable scanners.

Abstract: In some examples, a semiconductor package comprises a die pad, a semiconductor die on the die pad, and a mold compound covering the die pad and the semiconductor die. The semiconductor package includes a conductive component including a roughened surface, the roughened surface having a roughness ranging from an arithmetic mean surface height (SA) of 1.4 to 3.2. The mold compound is coupled to the roughened surface. The semiconductor package includes a bond wire coupling the semiconductor die to the roughened surface. The bond wire is directly coupled to the roughened surface without a precious metal positioned therebetween.

Abstract: Integration of a clustered network orchestrator with host configuration protocols in a distributed node network system can be performed and managed. Respective nodes of the node network can generate, and store in a data store, respective network configuration reports (NCRs) based on respective portions of network configuration-related information relating to an external network host configuration protocol that are received from an external device by the respective nodes. A network management component (NMC) can determine a first network configuration of the network of nodes based on analysis of the NCRs, wherein the first network configuration relates to a first group of network addresses. NMC can determine a second network configuration of the network of nodes based on analysis of other network configuration-related information associated with an internal network configuration protocol associated with the node network, wherein the second network configuration relates to a second group of network addresses.

Abstract: According to one embodiment of the present disclosure, an electrochemical water treatment reactor includes a first cavity with a wastewater inlet, a second cavity with a wastewater outlet, a spacer disposed between the first and second cavities, the spacer separating the first and second cavities from each other, an anode disposed in the first cavity, a cathode disposed in the second cavity, and a metal powder disposed in the first cavity and being in direct or indirect contact with the anode. The reactor can be used to efficiently remove contaminants from wastewater without consuming the anode.

Abstract: This invention relates to a hetero-dimeric multi-specific format of multiple antibody variable domains comprising a core of two split variable domain pairs wherein both variable light domains and the two cognate variable heavy domains are positioned in tandem on two separate protein chains, respectively, and wherein one of said variable domain pairs is specific for human serum albumin and the other said variable domain pair is specific for human CD3.