Patents by Inventor Terence James Smith
Terence James Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9994918Abstract: The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the Mycobacterium tuberculosis complex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of the Mycobacterium tuberculosis complex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.Type: GrantFiled: November 6, 2015Date of Patent: June 12, 2018Assignee: National University of Ireland, GalwayInventors: Kate Mary Reddington, Thomas Gerard Barry, Justin Joseph O'Grady, Terence James Smith
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Patent number: 9458514Abstract: The present invention use of to a portion of the RPS7 gene or its corresponding mRNA in a diagnostic assay for fungal and yeast species and sequences for use in such assays and methods.Type: GrantFiled: December 14, 2007Date of Patent: October 4, 2016Assignee: National University of Ireland, GalwayInventors: Thomas Gerard Barry, Terence James Smith, Majella Maher
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Publication number: 20160194688Abstract: The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the Mycobacterium tuberculosis complex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of the Mycobacterium tuberculosis complex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.Type: ApplicationFiled: November 6, 2015Publication date: July 7, 2016Inventors: Kate Mary Reddington, Thomas Gerard Barry, Justin Joseph O'Grady, Terence James Smith
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Patent number: 9243298Abstract: The current invention relates to a diagnostic kit for a bacterial species and/or fungal and/or yeast species comprising at least one oligonucleotide probe capable of binding to at least a portion of the LepA and/or Guf1 genes or its corresponding mRNA.Type: GrantFiled: June 15, 2009Date of Patent: January 26, 2016Assignee: National University of Ireland, GalwayInventors: Thomas Gerard Barry, Majella Maher, Terence James Smith, Justin O'Grady
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Patent number: 9206483Abstract: The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the Mycobacterium tuberculosis complex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of the Mycobacterium tuberculosis complex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.Type: GrantFiled: May 25, 2011Date of Patent: December 8, 2015Assignee: National University of Ireland, GalwayInventors: Kate Mary Reddington, Thomas Gerard Barry, Justin Joseph O'Grady, Terence James Smith
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Patent number: 8946127Abstract: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.Type: GrantFiled: March 4, 2013Date of Patent: February 3, 2015Assignees: Enterprise Ireland, National University of IrelandInventors: Thomas Gerard Barry, Terence James Smith
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Publication number: 20130296179Abstract: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.Type: ApplicationFiled: March 4, 2013Publication date: November 7, 2013Inventors: Thomas Gerard BARRY, Terence James SMITH
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Publication number: 20130274121Abstract: The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the Mycobacterium tuberculosis complex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of the Mycobacterium tuberculosis complex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.Type: ApplicationFiled: May 25, 2011Publication date: October 17, 2013Inventors: Kate Mary Reddington, Thomas Gerard Barry, Justin Joseph O'Grady, Terence James Smith
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Publication number: 20120258453Abstract: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.Type: ApplicationFiled: May 3, 2010Publication date: October 11, 2012Inventors: Thomas Gerard Barry, Terence James Smith
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Patent number: 8136522Abstract: A continuous positive airway pressure device which includes:—an inflatable breathable air reservoir provided with an air inlet/outlet;—a pressurized gas reservoir arranged to apply a predetermined substantially constant pressure on the breathable air reservoir, irrespective of the degree of inflation of the breathable air reservoir.Type: GrantFiled: July 4, 2006Date of Patent: March 20, 2012Assignee: Lifevent Medical LimitedInventors: Donald Ross McIntyre, Cindy McIntyre, legal representative, James Edward Miles, Geoffrey Mark Shaw, Michael William Ryan, William Jesse Chaloner, Terence James Smith, Lawrence Gordon Alloo, Robert Charles Berry
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Publication number: 20110217704Abstract: The current invention relates to a diagnostic kit for a bacterial species and/or fungal and/or yeast species comprising at least one oligonucleotide probe capable of binding to at least a portion of the LepA and/or Guf1 genes or its corresponding mRNA.Type: ApplicationFiled: June 15, 2009Publication date: September 8, 2011Inventors: Thomas Gerard Barry, Majella Maher, Terence James Smith, Justin O'Grady
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Patent number: 7972777Abstract: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.Type: GrantFiled: May 15, 2000Date of Patent: July 5, 2011Assignees: Enterprise Ireland, National University of Ireland, GalwayInventors: Thomas Gerard Barry, Terence James Smith
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Publication number: 20110111398Abstract: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.Type: ApplicationFiled: May 3, 2010Publication date: May 12, 2011Inventors: Thomas Gerard BARRY, Terence James Smith
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Publication number: 20090246764Abstract: A method for the detection of all strains of Group B Streptococcus (GBS) (Streptococcus agalactiae) in a mammal comprises isolating nucleic acid from a biological sample obtained from the mammal, detecting in the isolated nucleic acid a specific target region of GBS ssrA gene or tmRNA, an RNA transcript of the GBS ssrA gene, which is indicative of the presence of GBS. The isolated nucleic acid can be contacted with at least one oligonucleotide complementary to the specific target region of the GBS ssrA gene or tmRNA allowing a probe assay to be performed directly on the biological sample. Alternatively, the isolated nucleic acid can be amplified with at least one primer complementary to a specific target region of the GBS ssrA gene or tmRNA in a PCR-based assay.Type: ApplicationFiled: March 31, 2008Publication date: October 1, 2009Applicant: NATIONAL UNIVERSITY OF IRELAND GALWAYInventors: Thomas Gerard Barry, Majella Mary Maher, Terence James Smith
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Publication number: 20090199852Abstract: A continuous positive airway pressure device which includes:—an inflatable breathable air reservoir provided with an air inlet/outlet; —a pressurised gas reservoir arranged to apply a predetermined substantially constant pressure on the breathable air reservoir, irrespective of the degree of inflation of the breathable air reservoir.Type: ApplicationFiled: July 4, 2006Publication date: August 13, 2009Inventors: Donald Ross McIntyre, James Edward Miles, Geoffrey Mark Shaw, Michael William Ryan, William Jesse Chaloner, Terence James Smith, Lawrence Gordon Alloo, Robert Charles Berry, Cindy McIntyre
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Publication number: 20080233106Abstract: The invention relates to markers which find use in the diagnosis of labour or pre-term labour, to assays comprising such markers, to methods of identifying therapeutic agents which can prolong pregnancy, using these markers and to methods of treatment of pre-term labour, methods of prolonging gestation, or methods of suppressing labour contractility based on the markers.Type: ApplicationFiled: March 22, 2007Publication date: September 25, 2008Applicant: National University of IrelandInventors: Terence James Smith, Margaret O'Brien
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Patent number: 5674623Abstract: A solid photocurable film adhesive comprising (I) a photocurable material having, on average, more than one acrylic group per molecule, at least 20% by weight of said material being a urethane acrylate, a polyester acrylate or a mixture of a urethane acrylate and a polyester acrylate, (II) as sole or major solid film-forming component, a solid polyvinylacetal and (III) a photoinitiator for photopolymerisation of acrylic compounds.The film adhesive is useful in the production of data-carrying laminates such as identity cards.Type: GrantFiled: November 14, 1994Date of Patent: October 7, 1997Assignee: Ciba-Geigy CorporationInventors: Margaret Ruth Haddon, Terence James Smith