Patents by Inventor Terry Lyle

Terry Lyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidine thrombin inhibitors
    Patent number: 5510369
    Abstract: Compounds of the invention have the following structure: ##STR1## for example ##STR2## These compounds inhibit thrombin and associated thrombosis.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 23, 1996
    Assignee: Merck & Co., Inc.
    Inventors: William C. Lumma, Roger M. Freidinger, Stephen F. Brady, Philip E. Sanderson, Dong-Mei Feng, Terry A. Lyle, Kenneth J. Stauffer, Thomas J. Tucker, Joseph P. Vacca
  • Peptides having ANF activity
    Patent number: 5057603
    Abstract: Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein X is L-Ile, D-Ile, D-allo-Ile, L-Met or D-Met, Y is Gly, L-Ala or D-Ala, A is optionally absent or is Ser, Ser-Ser, Arg-Ser-Ser, Arg-Arg-Ser-Ser, Leu-Arg-Arg-Ser-Ser or Ser-Leu-Arg-Arg-Ser-Ser and B is optionally absent or is Asn, Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, or Asn-Ser-Phe-Arg-Tyr, provided that at least one of Y.sup.10, Y.sup.16, Y.sup.20 or Y.sup.22 is Ala or D-Ala, and the amides, lower alkyl esters and the physiologically acceptable metal salts and acid addition salts thereof.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: October 15, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Ruth F. Nutt, Theresa M. Williams, Daniel F. Veber, Terry A. Lyle
  • Polyhydro derivatives of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
    Patent number: 4870080
    Abstract: 10,11-Dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imines and derivatives thereof wherein one or the other or both benzo rings are hydrogenated are active anticonvulsants and atagonists of N-methyl-D-aspartate.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: September 26, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Theresa R. Lamanec, Terry A. Lyle
  • Derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
    Patent number: 4870079
    Abstract: Fluoro-and hydroxy-derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines wherein the substituents are on non-benzenoid carbons are active anticonvulsants and antagonists of N-methyl-D-aspartate.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: September 26, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Susan F. Britcher, Wayne J. Thompson, Terry A. Lyle, Sandor L. Varga
  • Novel cyclic tetrapeptide
    Patent number: 4703034
    Abstract: There is disclosed a series of novel cyclic tetrapeptides related to somatostatin. The compounds have surprisingly been found to have the activity of increasing blood glucose when administered. The compounds are prepared using the solid phase or mixed anhydride synthesis methods and compositions and methods utilizing the novel compounds are also disclosed.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: October 27, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Roger Freidinger, Ruth F. Nutt, Terry A. Lyle, Richard Saperstein