Patents by Inventor Teruo Fujii

Teruo Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11186860
    Abstract: A microchamber array device having built-in reaction microchambers, in which the dilution ratio can be greatly increased at the same time as dramatically raising cell recovery efficiency, and an inspection object analysis method using said device are provided. This microchamber array device is provided with: a microchamber array 1 for cell capture by electrophoresis comprising an arrangement of a substrate 2, electrodes 3 and photoresists 4; and a reaction microchamber array 6 which is separated from the capture microchamber array 1, and which is formed from reaction microchamber 8 comprising micro channels 7 arranged so as to be opposite of the aforementioned microchamber array 1.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: November 30, 2021
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Teruo Fujii, Soo Hyeon Kim, Ken Ogata
  • Patent number: 11180797
    Abstract: An object is to provide a component for molecular Computing and a method of molecular Computing. A component for molecular Computing, the component comprising: a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a continuous séquence of nucleic acid base.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: November 23, 2021
    Assignees: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Guillaume Gines, Yannick Rondelez, Teruo Fujii
  • Publication number: 20210331163
    Abstract: A microfluidic chip is inserted into a slot that extends horizontally, and is used as a microfluidic device. The microfluidic chip includes an upper surface, a lower surface opposite the upper surface, a flow passage for fluid located between the upper surface and the lower surface, and two communication holes communicating with the flow passage and opening at the upper surface.
    Type: Application
    Filed: October 16, 2019
    Publication date: October 28, 2021
    Applicants: NOK CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Takumi YOSHITOMI, SooHyeon KIM, Teruo FUJII, Mingyue SUN
  • Publication number: 20210316305
    Abstract: A microfluidic chip includes an upper surface, a lower surface opposite the upper surface, a flow passage for fluid located between the upper surface and the lower surface, a communication hole that communicate with the flow passage and open at the upper surface or the lower surface, and an annular seal formed from an elastomer, the annular seal being placed in contact with or being formed on the upper surface or the lower surface at which the communication hole opens and surrounding the communication hole. The microfluidic chip further includes a support structure fixed at a position within the flow passage, the position overlapping the annular seal, the support structure securing a height of the flow passage so as to prevent blockage of the flow passage.
    Type: Application
    Filed: October 16, 2019
    Publication date: October 14, 2021
    Applicants: NOK CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Takumi YOSHITOMI, SooHyeon KIM, Teruo FUJII, Mingyue SUN
  • Patent number: 11111529
    Abstract: An object is to provide a method of eliminating background amplification in detection of rare nucleic acids based on isothermal amplification. The method comprising steps of: preparing a mixture including solution and enzymes, and adding a first and a second template into the mixture, wherein the first template is an amplification template, and the second template is a leak absorption template. Methods to use this approach for multiplexed, ultrasensitive and ultra-specific detection of nucleic acids are presented.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 7, 2021
    Assignees: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yannick Rondelez, Guillaume Gines, Kevin Montagne, Teruo Fujii
  • Patent number: 11067535
    Abstract: Provided are a fluorescent testing system, a dielectrophoresis device, and a molecular testing method that measure only fluorescence emitted from a test object without separating excitation light and the fluorescence by an optical filter and that are able to prevent reduction of an application range of a type of the fluorescence.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: July 20, 2021
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Yoshihisa Fujimoto, Takeshi Mitsunaka, Soo-Hyeon Kim, Teruo Fujii
  • Publication number: 20210101115
    Abstract: An object trapping device enables efficiently trapping a plurality of objects in a specific combination. Each of a first electrode pair (13), a second electrode pair (14), and a third electrode pair (15) in an electrode pair group (3) is applied with an individual AC voltage and traps an object by dielectrophoresis generated in accordance with the AC voltage that is applied.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 8, 2021
    Applicants: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: KUNIHIKO IIZUKA, TAKESHI MITSUNAKA, YOSHIHISA FUJIMOTO, TERUO FUJII, SOO-HYEON KIM
  • Publication number: 20210054320
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons, at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are closed and top ends of the first chambers and the second chambers are open.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Inventors: TERUO FUJII, YOSHIHO IKEUCHI, SHOHEI KANEDA, JIRO KAWADA
  • Patent number: 10890528
    Abstract: Provided are a fluorescent testing system, a molecular testing method, and a fluorescent testing method that can avoid enlargement and complication. A fluorescent testing system (1) includes: an excitation light source (23) that radiates excitation light (L1) to protein to which a fluorescent probe is added; a silicon integrated circuit (10) including a photon detection unit (13) that detects light by a photodiode (12); a holding layer (30) including a microwell (31) that is provided above the photodiode (12) and holds the protein to which the fluorescent probe is added; and a control unit (24) that causes the excitation light source (23) to radiate the excitation light (L1) to the protein which. is held and to which the fluorescent probe is added and causes the photon detection unit (13), after extinguishment of the excitation light (L1), to detect fluorescence emitted from the protein to which the fluorescent probe is added.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: January 12, 2021
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Yoshihisa Fujimoto, Soo-Hyeon Kim, Teruo Fujii
  • Patent number: 10865372
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are closed and top ends of the first chambers and the second chambers are open.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: December 15, 2020
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Teruo Fujii, Yoshiho Ikeuchi, Shohei Kaneda, Jiro Kawada
  • Publication number: 20200283722
    Abstract: A cell capture apparatus includes a cell separation unit having a flat plate shape and a cell capture unit having a flat plate shape located therebelow. A liquid sample and a carrier liquid flow in a cell-separation flow passage of the cell separation unit. The liquid sample contains multiple large cells, multiple small cells, and a sample liquid component. The cell-separation flow passage separates a set of large cells and the carrier liquid from a set of small cells and the sample liquid component. The cell capture unit includes a large-cell flow passage in which the set of large cells and the carrier liquid flows, and multiple electrode wires for attracting the large cells by means of dielectrophoresis. Multiple cell capturing wells are formed in the large-cell flow passage. Each of the multiple cell capturing wells has a size that can capture one of the large cells attracted by the electrode wires.
    Type: Application
    Filed: October 2, 2018
    Publication date: September 10, 2020
    Applicants: NOK CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Takayuki KOMORI, SooHyeon KIM, Teruo FUJII
  • Publication number: 20200172967
    Abstract: An object is to provide a component for molecular Computing and a method of molecular Computing. A component for molecular Computing, the component comprising: a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a continuous sequence of nucleic acid base.
    Type: Application
    Filed: February 16, 2016
    Publication date: June 4, 2020
    Applicants: THE UNIVERSITY OF TOKYO, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Guillaume GINES, Yannick RONDELEZ, Teruo FUJII
  • Publication number: 20200158620
    Abstract: A size reduction in an optical system that detects a fluorescent photon is achieved. A photon detection operation of a photon detection unit (21) is controlled on the basis of timing of an irradiation operation of an excitation light source (50), and after excitation light emitted to a microfluidic channel (10) is switched off, a fluorescent photon generated by a target flowing in the microfluidic channel (10) is detected.
    Type: Application
    Filed: June 5, 2018
    Publication date: May 21, 2020
    Applicants: SHARP KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, THE UNIVERSITY OF TOKYO
    Inventors: KUNIHIKO IIZUKA, YOSHIHISA FUJIMOTO, TAKESHI MITSUNAKA, TERUO FUJII, SOO-HYEON KIM
  • Publication number: 20200149096
    Abstract: An object is to provide a method of eliminating background amplification in detection of rare nucleic acids based on isothermal amplification. The method comprising steps of: preparing a mixture including solution and enzymes, and adding a first and a second template into the mixture, wherein the first template is an amplification template, and the second template is a leak absorption template. Methods to use this approach for multiplexed, ultrasensitive and ultra-specific detection of nucleic acids are presented.
    Type: Application
    Filed: February 16, 2017
    Publication date: May 14, 2020
    Applicants: THE UNIVERSITY OF TOKYO, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yannick RONDELEZ, Guillaume GINES, Kevin MONTAGNE, Teruo FUJII
  • Publication number: 20200016608
    Abstract: A particle sorting apparatus a channel that includes a trunk channel formed along a specific upper surface and deflection electrode pairs that sort a non-target minute particle and a target minute particle respectively in a direction substantially perpendicular to the specific upper surface and a direction along the specific upper surface by dielectrophoresis.
    Type: Application
    Filed: July 5, 2019
    Publication date: January 16, 2020
    Inventors: KUNIHIKO IIZUKA, TAKESHI MITSUNAKA, DAIKI SATO, TERUO FUJII, SOO-HYEON KIM
  • Publication number: 20190285579
    Abstract: Provided are a fluorescent testing system, a dielectrophoresis device, and a molecular testing method that measure only fluorescence emitted from a test object without separating excitation light and the fluorescence by an optical filter and that are able to prevent reduction of an application range of a type of the fluorescence.
    Type: Application
    Filed: August 2, 2017
    Publication date: September 19, 2019
    Applicants: SHARP KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: KUNIHIKO IIZUKA, YOSHIHISA FUJIMOTO, TAKESHI MITSUNAKA, SOO-HYEON KIM, TERUO FUJII
  • Publication number: 20190249220
    Abstract: A microchamber array device having built-in reaction microchambers, in which the dilution ratio can be greatly increased at the same time as dramatically raising cell recovery efficiency, and an inspection object analysis method using said device are provided. This microchamber array device is provided with: a microchamber array 1 for cell capture by electrophoresis comprising an arrangement of a substrate 2, electrodes 3 and photoresists 4 and a reaction microchamber array 6 which is separated from the capture microchamber array 1, and which is formed from reaction microchamber 8 comprising micro channels 7 arranged so as to be opposite of the aforementioned microchamber array 1.
    Type: Application
    Filed: November 24, 2016
    Publication date: August 15, 2019
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TERUO FUJII, SOO HYEON KIM, KEN OGATA
  • Publication number: 20190250102
    Abstract: Provided are a fluorescent testing system, a molecular testing method, and a fluorescent testing method that can avoid enlargement and complication. A fluorescent testing system (1) includes: an excitation light source (23) that radiates excitation light (L1) to protein to which a fluorescent probe is added; a silicon integrated circuit (10) including a photon detection unit (13) that detects light by a photodiode (12); a holding layer (30) including a microwell (31) that is provided above the photodiode (12) and holds the protein to which the fluorescent probe is added; and a control unit (24) that causes the excitation light source (23) to radiate the excitation light (L1) to the protein which. is held and to which the fluorescent probe is added and causes the photon detection unit (13), after extinguishment of the excitation light (L1), to detect fluorescence emitted from the protein to which the fluorescent probe is added.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 15, 2019
    Inventors: KUNIHIKO IIZUKA, YOSHIHISA FUJIMOTO, SOO-HYEON KIM, TERUO FUJII
  • Publication number: 20190127672
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are dosed and top ends of the first chambers and the second chambers are open.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 2, 2019
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TERUO FUJII, YOSHIHO IKEUCHI, SHOHEI KANEDA, JIRO KAWADA
  • Publication number: 20180093271
    Abstract: The present disclosure relates to a microdevice for capturing particles from a sample, a method for capturing particles from a sample, and a method for concentrating or separating particles using the same.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 5, 2018
    Applicants: The University of Tokyo, ARKRAY, Inc.
    Inventors: Teruo Fujii, Soo Hyeon Kim, Hiroshi Ito