Patents by Inventor Teruo Fujii

Teruo Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190127672
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are dosed and top ends of the first chambers and the second chambers are open.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 2, 2019
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TERUO FUJII, YOSHIHO IKEUCHI, SHOHEI KANEDA, JIRO KAWADA
  • Publication number: 20180093271
    Abstract: The present disclosure relates to a microdevice for capturing particles from a sample, a method for capturing particles from a sample, and a method for concentrating or separating particles using the same.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 5, 2018
    Applicants: The University of Tokyo, ARKRAY, Inc.
    Inventors: Teruo Fujii, Soo Hyeon Kim, Hiroshi Ito
  • Patent number: 9746494
    Abstract: The present invention makes it possible to easily and efficiently observe a specimen contained in a fluid without using a filtration device separate from a scanning probe microscope by attaching a filter holding part holding a filter to a fluid cell of a specimen support. Therefore, a specimen support 10, for holding a specimen subject to observation by the scanning probe microscope, comprises a fluid cell 11, into which fluid including the specimen is introduced, and a filter unit including a filter 15, which allows the fluid passage and at least a part of the specimen is adhered to. The fluid cell 11 includes a fluid entrance, the filter unit includes a fluid exit opening, and the filter unit is attached to one side of the fluid cell 11.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: August 29, 2017
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Shuhei Nishida, Teruo Fujii
  • Publication number: 20170059610
    Abstract: The present invention makes it possible to easily and efficiently observe a specimen contained in a fluid without using a filtration device separate from a scanning probe microscope by attaching a filter holding part holding a filter to a fluid cell of a specimen support. Therefore, a specimen support 10, for holding a specimen subject to observation by the scanning probe microscope, comprises a fluid cell 11, into which fluid including the specimen is introduced, and a filter unit including a filter 15, which allows the fluid passage and at least a part of the specimen is adhered to. The fluid cell 11 includes a fluid entrance, the filter unit includes a fluid exit opening, and the filter unit is attached to one side of the fluid cell 11.
    Type: Application
    Filed: February 19, 2015
    Publication date: March 2, 2017
    Inventors: SHUHEI NISHIDA, TERUO FUJII
  • Patent number: 9492842
    Abstract: Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 ?m (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: November 15, 2016
    Assignees: KISCO LTD., DAISANKASEI CO., LTD., The University of Tokyo
    Inventors: Yasuo Yoshimoto, Kentaro Kamimae, Yuki Tanabe, Taku Oguni, Takashi Inoue, Tsutomu Mochizuki, Makoto Hirama, Teruo Fujii, Hiroshi Kimura, Hideto Tozawa
  • Publication number: 20160139020
    Abstract: The invention relates to an installation (1) for determining the diffusion profile of at least one molecule through skin, comprising: a microfluidic chip (4) comprising: a donor compartment (10) intended to contain a test solution comprising the or each molecule; a receptor compartment (12) intended to contain a receptor solution; and a membrane (14) with skin-mimetic barrier properties arranged between the donor compartment (10) and the receptor compartment (12) so that the test solution diffuses through the membrane (14) from the donor compartment (10) into the receptor compartment (12); and an analyzer (8) for measuring a physical parameter of the solution contained in the receptor compartment (12) as the test solution diffuses through the membrane (14), and said analyzer (8) being configured for measuring the physical parameter in the receptor compartment (12), the analyzer (8) being further configured for calculating the diffusion profile of the or each molecule through skin from the measured physi
    Type: Application
    Filed: May 16, 2013
    Publication date: May 19, 2016
    Inventors: Alexandre Nicolas, Sébastien Gregoire, Christophe Provin, Christophe Hadjur, Teruo Fujii
  • Patent number: 8906644
    Abstract: A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed in a short period of time. Further, the formed polarity can be maintained for a longer period.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: December 9, 2014
    Assignees: The University of Tokyo, Mitsubishi Chemical Medience Corporation
    Inventors: Hitoshi Matsui, Yasuyuki Sakai, Teruo Fujii, Shoji Takeuchi, Yukiko Tsuda
  • Publication number: 20140212974
    Abstract: Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 ?m (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).
    Type: Application
    Filed: June 22, 2012
    Publication date: July 31, 2014
    Applicants: KISCO LTD., THE UNIVERSITY OF TOKYO, DAISANKASEI CO., LTD.
    Inventors: Yasuo Yoshimoto, Kentaro Kamimae, Yuki Tanabe, Taku Oguni, Takashi Inoue, Tsutomu Mochizuki, Makoto Hirama, Teruo Fujii, Hiroshi Kimura, Hideto Tozawa
  • Publication number: 20130165348
    Abstract: Provided are a method and a device for synthesizing proteins from DNA molecules captured in microchambers, whereby the distance between microchambers can be shortened, thereby allowing the density of arrays to be increased. Microchambers (32) are arranged at a high density. A DNA solution (34) which has been diluted so as to capture one DNA molecule on average is enclosed in the microchambers (32). Then, mRNA is synthesized using one DNA molecule on average as a template. Based on this mRNA, a protein (37) is extracellularly synthesized.
    Type: Application
    Filed: December 8, 2010
    Publication date: June 27, 2013
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Teruo Fujii, Soo-Hyeon Kim, Shoji Takeuchi, Dominique Fourmy, Satoko Yoshizawa
  • Patent number: 8383409
    Abstract: The invention is directed to methods for the propagation or cultivation of cells including preparing a cell culture substrate, wherein the cell culture substrate includes a substrate and a layer formed by surface modification. The layer includes a polymer containing an amino group. The polymer is produced by reacting a polymer represented by formula (II): with a polymer having at least one amino group, —NH2, capable of forming a Schiff base in a monomer of formula (II), thereby forming a polymer layer constituting the layer formed by surface modification. “n” in Formula (II) is 0 or a positive integer, and m is a positive integer. n and m represent the degree of polymerization. Formula (II) is formed by chemical vapor deposition of formyl[2.2]paracyclophane. The methods further include providing cells in a medium; inoculating the cells onto the cell culture substrate; and culturing the cells, wherein the cells adhere to the cell culture substrate.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: February 26, 2013
    Assignees: Kisco Ltd., Daisan Kasei Co., Ltd., The University of Tokyo
    Inventors: Shin Ohya, Takashi Inoue, Takatoki Yamamoto, Teruo Fujii, Yasuyuki Sakai, Masaki Nishikawa, Hitomi Sakai, Hirosuke Naruto
  • Publication number: 20120183989
    Abstract: A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed in a short period of time. Further, the formed polarity can be maintained for a longer period.
    Type: Application
    Filed: July 28, 2010
    Publication date: July 19, 2012
    Inventors: Hitoshi Matsui, Yasuyuki Sakai, Teruo Fujii, Shoji Takeuchi, Yukiko Tsuda
  • Publication number: 20110136234
    Abstract: A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.
    Type: Application
    Filed: February 3, 2011
    Publication date: June 9, 2011
    Inventors: Shin OHYA, Takashi Inoue, Takatoki Yamamoto, Teruo Fujii, Yasuyuki Sakai, Masaki Nishikawa, Hitomi Sakai, Hirosuke Naruto
  • Publication number: 20090042295
    Abstract: A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.
    Type: Application
    Filed: August 8, 2007
    Publication date: February 12, 2009
    Applicants: KISHIMOTO SANGYO CO., LTD., DAISANKASEI CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Shin Ohya, Takashi Inoue, Takatoki Yamamoto, Teruo Fujii, Yasuyuki Sakai, Masaki Nishikawa, Hitomi Sakai, Hirosuke Naruto
  • Publication number: 20080145925
    Abstract: A cell culture chamber includes: a top compartment and a bottom compartment that are separated by a semi-permeable membrane inside a supporting body; a culture solution supply flow path that supplies culture solution to an interior of the bottom compartment; a culture solution discharge flow path that discharges culture solution from the interior of the bottom compartment; a circulation flow path that is used to circulate fluid within the interior of the top compartment; and a cell culturing portion is formed inside the top compartment by a sieve structure that is formed by aperture portions through which a fluid is able to pass but through which cultured cells cannot pass, and by wall portions.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 19, 2008
    Inventors: Yasuyuki Sakai, Teruo Fujii, Serge Ostrovidov, Hiroaki Inui, Jinji Mizuno
  • Patent number: 7316569
    Abstract: An evaluation apparatus of scientific phenomena, including: a base plate of a plate-like body on whose surface is formed an elongated groove having a transversely cross-sectional area of not more than 1 mm2; and a cover plate that is disposed on a surface of the base plate in close contact therewith and forms a fine flow passage on the base plate by covering the elongated groove, wherein scientific phenomena in the fine flow passage can be visually recognized.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: January 8, 2008
    Assignee: FUJIFILM Corporation
    Inventors: Yasunori Ichikawa, Tomohide Ueyama, Fumiko Shiraishi, Seiji Sugiyama, Teruo Fujii
  • Publication number: 20070212773
    Abstract: An electrical signal measuring device that can measure electrical characteristics of cells in culture in real time and with high accuracy while maintaining them in a favorable state and an electrical signal measuring method that uses the device are disclosed. The electrical signal measuring device 1 for cells in culture includes a support body 2, a compartment in the support body, a semipermeable membrane 3, and electrodes, in which the compartment is divided by the semipermeable membrane 3 into an upper compartment 4 and a lower compartment 5; an upper electrode 61 is provided in the upper compartment 4, and a lower electrode 62 that faces the upper electrode 61 and whose facing surface 621 is in contact with the semipermeable membrane 3 is provided in the lower compartment 5; and an upper perfusion channel and a lower perfusion channel are provided in the support body 2 to separately perfuse fluid in the upper compartment 4 and the lower compartment 5 is disclosed.
    Type: Application
    Filed: February 15, 2007
    Publication date: September 13, 2007
    Inventors: Teruo Fujii, Yasuyuki Sakai, Serge Ostrovidov
  • Patent number: 7259849
    Abstract: There is provided an optical system 8 for a micro analyzing system capable of precisely analyzing a sample. In the optical system 8, after light beams leaving the tip of an optical fiber 14 pass through a condensing part 13, a sample moving in a separation passage 6 due to electrophoresis is irradiated with the light beams. The condensing part 13 includes a first aspherically cylindrical surface 10 being convex toward the optical fiber 14, a second aspherically cylindrical surface 11 being convex on the opposite side to the first aspherically cylindrical surface 10, and a third aspherically cylindrical surface 12 being convex toward the second aspherically cylindrical surface 11. The first through third aspherically cylindrical surfaces 10 through 12 are arranged in that order from the side of the optical fiber 14 toward the separation passage 6.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: August 21, 2007
    Assignee: Enplas Corporation
    Inventors: Koichi Ono, Teruo Fujii, Serge Camou
  • Patent number: 7189367
    Abstract: In order to be capable of a chemical reaction, analysis or the like wherein a small amount of samples is used, a reactor comprises a flat plate-like first substrate the inside of which is provided with a heating means; and a flat plate-like second substrate, which is placed on the top of the above-described first substrate, and on a surface thereof to be placed on the top of the above-described first substrate a flow channel having a predetermined contour has been defined.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: March 13, 2007
    Assignee: Riken
    Inventors: Takatoki Yamamoto, Teruo Fujii, Jong Wook Hong, Isao Endo
  • Publication number: 20050186546
    Abstract: An evaluation apparatus of scientific phenomena, comprising: a base plate of a plate-like body whose surface is formed a long groove having a transversely cross-sectional area of not more than 1 mm2; and a cover plate that is disposed on a surface of the base plate in close contact therewith and forms a fine flow passage on the base plate by covering the long groove, wherein scientific phenomena in the flow passage can be visually recognized.
    Type: Application
    Filed: February 22, 2005
    Publication date: August 25, 2005
    Inventors: Yasunori Ichikawa, Tomohide Ueyama, Fumiko Shiraishi, Seiji Sugiyama, Teruo Fujii
  • Patent number: 6920382
    Abstract: The present invention provides a system for performing procedures to request repair, without troubling the driver, when a car breaks down, as well as various onboard peripheral apparatuses and cellular phone used for this system. This system comprises an onboard peripheral apparatus having a failure detector, an onboard main controller for managing car information, a cellular phone which can make wireless connection to the onboard main controller, and a response center for receiving requests for car repairs and maintenance and making arrangements therefor. When a failure is detected, repair request is transmitted to the response center through wireless communication together with the user ID of the driver. Based on this request, the response center acquires remedy information from a car manufacturer and makes arrangements for repair and provides this remedy information to a repair shop.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: July 19, 2005
    Assignee: Hitachi, Ltd.
    Inventors: Makoto Katagishi, Yoshiro Mikami, Teruo Fujii, Kenji Sano