Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a ?-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a ?-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Microphones are provided at an air inlet of the engine and a vehicle-cabin-side wall surface of an engine room, and engine sounds are picked up. The engine sound is processed by a signal processing section, and the processed engine sound is output from a speaker provided in a vehicle cabin. The signal processing section is provided with a filter which simulates a sound insulation characteristic of the vehicle cabin and a transformation section for processing the engine sound according to driving condition. A spectrum transformation characteristic of the transformation section is determined according to values detected by a vehicle speed sensor, an engine speed sensor, and an accelerator depression sensor, and a spectrum of the engine sound is transformed by means of specification of the spectrum transformation characteristic, thereby enhancing an engine sound.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA. An siRNA having a full length of 30 or fewer nucleotides and targeting a sequence consisting of 17 to 23 consecutive bases selected from the group consisting of bases at positions 1285 to 1318, bases at positions 1398 to 1418, bases at positions 1434 to 1463, bases at positions 1548 to 1579, bases at positions 1608 to 1628, bases at positions 1700 to 1726, bases at positions 1778 to 1798, bases at positions 1806 to 1826, and bases at positions 1887 to 1907 of SEQ ID NO: 1.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA. An siRNA having a full length of 30 or fewer nucleotides and targeting a sequence consisting of 17 to 23 consecutive bases selected from the group consisting of bases at positions 1285 to 1318, bases at positions 1398 to 1418, bases at positions 1434 to 1463, bases at positions 1548 to 1579, bases at positions 1608 to 1628, bases at positions 1700 to 1726, bases at positions 1778 to 1798, bases at positions 1806 to 1826, and bases at positions 1887 to 1907 of SEQ ID NO: 1.

Abstract: Microphones are provided at an air inlet of the engine and a vehicle-cabin-side wall surface of an engine room, and engine sounds are picked up. The engine sound is processed by a signal processing section, and the processed engine sound is output from a speaker provided in a vehicle cabin. The signal processing section is provided with a filter which simulates a sound insulation characteristic of the vehicle cabin and a transformation section for processing the engine sound according to driving condition. A spectrum transformation characteristic of the transformation section is determined according to values detected by a vehicle speed sensor, an engine speed sensor, and an accelerator depression sensor, and a spectrum of the engine sound is transformed by means of specification of the spectrum transformation characteristic, thereby enhancing an engine sound.

Abstract: Microphones are provided at an air inlet of the engine and a vehicle-cabin-side wall surface of an engine room, and engine sounds are picked up. The engine sound is processed by a signal processing section, and the processed engine sound is output from a speaker provided in a vehicle cabin. The signal processing section is provided with a filter which simulates a sound insulation characteristic of the vehicle cabin and a transformation section for processing the engine sound according to driving condition. A spectrum transformation characteristic of the transformation section is determined according to values detected by a vehicle speed sensor, an engine speed sensor, and an accelerator depression sensor, and a spectrum of the engine sound is transformed by means of specification of the spectrum transformation characteristic, thereby enhancing an engine sound.

Abstract: In the floor base panel (40), an area on the support board (33) of the vibration proof support leg (30) is formed solid, and in the other area, a plurality of cavities (41) extending parallel to the floor surface are formed. Thereby, because the vibration energy propagated from the impact point of the floor base panel (40) is reflected on the boundary between the cavity formation area and the solid area, and repeatedly passes the cavity formation area, it is attenuated in a short time, and the vibration energy or sound energy transmitted to a slab (20) can be reduced.

Abstract: Noises in an interior of an automobile are estimated based on sensed values of sensors that sense a speed (driving speed), an accelerator opening angle, and an engine speed respectively. This estimation is carried out by searching a noise estimation database. A masking characteristic of an audio signal is deduced based on the estimated noises. An equalizing characteristic to prevent a masking of the audio signal is decided based on the masking characteristic, and then the audio signal is equalized.

Abstract: Sound radiating structure includes a plurality of pipes each defining an inner cavity along the length of the pipe. Each of the pipes has an end opening at one end and is closed at the other end with a closure. Each of the pipes also has a side opening in its one side portion. When a sound is input to the sound radiating structure, it re-radiates various sound waves through a number of the end and side openings together with reflected sound waves.

Abstract: An electronic musical instrument according to the invention stores a difference tone identifying table which associates musical sounds of different pitches with a difference tone perceived from the musical sounds of different pitches. Receiving an instruction to simultaneously produce musical sounds of different pitches, the electronic musical instrument extracts a difference tone corresponding to the musical sounds of different pitches from the difference tone identifying table and generates then outputs a sound signal corresponding to the extracted difference tone and the musical sounds of different pitches.

Abstract: A hollow panel (10) includes comprise hollow portions (12) between front and rear outer sides (11) having a substantially flat plate shape. In the hollow panel (10), the surface density is partially differentiated, whereby a lack of sound insulation due to the coincidence effect at a specific frequency is prevented from occurring. The surface density or the rigidity can be made non-uniform to suppress the lack of sound insulation, by differentiating sectional areas by forming plural kinds of widths of the hollow portions (12), or by differentiating the distances between partition walls (13) or the thicknesses of the walls.