Patents by Inventor Tetsuo Nagano
Tetsuo Nagano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160102336Abstract: [Problem] To provide a novel fluorescent probe for detecting the activity of calpain. [Solution] A compound represented by general formula (I) or a salt thereof.Type: ApplicationFiled: March 4, 2014Publication date: April 14, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Yu KUSHIDA
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Publication number: 20160047748Abstract: [Problem] To provide a fluorescent probe having a novel fluorophore. [Solution] A compound represented by general formula (I), or a salt thereof.Type: ApplicationFiled: March 4, 2014Publication date: February 18, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Kazuhisa HIRABAYASHI
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Patent number: 9250232Abstract: A compound represented by the formula (I) [R1 represents hydrogen atom or a substituent; R2, R3, R6, and R7 represent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; R4 and R5 represent an alkyl group or an aryl group; R8 and R9 represent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement.Type: GrantFiled: February 15, 2013Date of Patent: February 2, 2016Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Kazuhisa Hirabayashi, Yuko Toki
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Publication number: 20160023988Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: ApplicationFiled: September 15, 2015Publication date: January 28, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Yuichiro KOIDE, Takahiro EGAWA, Kazuhisa HIRABAYASHI
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Publication number: 20160002247Abstract: A compound of formula (I) wherein variables are as defined herein having an autotaxin inhibitory effect and a pharmaceutical composition comprising the same.Type: ApplicationFiled: February 27, 2014Publication date: January 7, 2016Applicants: THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY, Shionogi & Co., Ltd.Inventors: Tetsuo NAGANO, Takayoshi OKABE, Hirotatsu KOJIMA, Mitsuyasu KAWAGUCHI, Osamu NUREKI, Ryuichiro ISHITANI, Hiroshi NISHIMASU, Junken AOKI, Nobuyuki TANAKA, Chiaki FUJIKOSHI, Yusuke TATENO, Toshihiro WADA
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Publication number: 20150353585Abstract: [Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. [Solution] The compound represented by general formula (I) or a salt thereof.Type: ApplicationFiled: January 7, 2014Publication date: December 10, 2015Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Takahiro EGAWA, Yu KUSHIDA, Koji NUMASAWA, Takuya MYOCHIN, Wen PIAO
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Patent number: 9187499Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: GrantFiled: January 19, 2012Date of Patent: November 17, 2015Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Kazuhisa Hirabayashi
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Patent number: 9170266Abstract: A compound represented by the formula (I) (one of substituents represented by R1 is a trapping group for an object substance for measurement; R2 and R3 represent hydrogen, alkyl, or halogen; R4 and R5 represent alkyl or aryl; R6 and R7 represent hydrogen, alkyl, or halogen; R8 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, and X represents silicon, germanium, or tin, which can be used as a fluorescent probe that enables red color bioimaging using intramolecular photoinduced electron transfer.Type: GrantFiled: February 17, 2012Date of Patent: October 27, 2015Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa
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Patent number: 9156827Abstract: An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6 alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; R4 represents hydrogen atom, a C1-6 alkyl group, a C1-6 alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6 alkyl group and the like; R8 represents hydrogen atom, a C1-6 alkyl group and the like; A represents —O—, —S—, or —CH2—; D represents —C? or —N?; X represents methylene group, —O—, or —CO—; Q represents —N? or —C(R8)?; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.Type: GrantFiled: April 28, 2011Date of Patent: October 13, 2015Assignees: THE UNIVERSITY OF TOKYO, RIKENInventors: Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Nae Saito, Hirofumi Nakano, Masanao Abe, Akiko Tanaka, Teruki Honma, Shigeyuki Yokoyama, Keiko Tsuganezawa, Hitomi Yuki
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Publication number: 20150212073Abstract: A compound represented by the formula (I) [R1 represents hydrogen atom or a substituent; R2, R3, R6, and R7 represent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; R4 and R5 represent an alkyl group or an aryl group; R8 and R9 represent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement.Type: ApplicationFiled: February 15, 2013Publication date: July 30, 2015Inventors: Tetsuo Nagano, Kenjiro Hanaoka, Kazuhisa Hirabayashi, Yuko Toki
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Patent number: 9051597Abstract: The object of the invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme and compound represented by formula (I) and a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme, which includes the compound.Type: GrantFiled: September 18, 2013Date of Patent: June 9, 2015Assignees: Mitsubishi Rayon Co., Ltd., The University of TokyoInventors: Yasuteru Urano, Tetsuo Nagano, Tomoe Ohta, Fujio Yu
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Publication number: 20150152469Abstract: [Problem] To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe. [Solution] A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group.Type: ApplicationFiled: May 29, 2013Publication date: June 4, 2015Applicant: THE UNIVERSITY OF TOKYOInventors: Yasuteru Urano, Masayo Sakabe, Tetsuo Nagano, Takeaki Ishizawa, Suguru Yamashita, Norihiro Kokudo, Mako Kamiya
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Publication number: 20150151859Abstract: Provided is a simple apparatus and a simple method for readily dispensing a gel after electrophoresis used for analysis of protein or DNA into respective wells of a microtiter plate. Using a microtiter plate 10 and a pressing tool 20, a gel plate 30 is divided into gel fragments 31 and the gel fragments 31 are then dispensed into respective wells 11 of the microtiter plate 10. In the microtiter plate 10, end portions 13 of a lattice-shaped partition wall 12 constituting the wells 11 of a square shape are formed to be sharp. The pressing tool 20 includes a frame portion 21 configured to be fit onto the microtiter plate 10, and a lattice-shaped partition wall 23 formed thereon. The lattice-shaped partition wall 23 includes end surfaces 26 each having a predetermined width configured to be opposed to and abut against the end portions 13 of the lattice-shaped partition wall 12 of the microtiter plate 10 when the pressing tool 20 is fit onto the microtiter plate.Type: ApplicationFiled: February 27, 2014Publication date: June 4, 2015Applicant: SYORYUKENSETSU CORPORATIONInventors: Tetsuo Nagano, Toru Komatsu, Satoru Konno, Masahiro Simoda
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Patent number: 8895317Abstract: A compound represented by the general formula (I) [R1 and R2 are amino groups that substitute at adjacent positions on the benzene ring; R3 and R4 are halogen atoms; R5 and R6 represent hydrogen atom, an acyl group or an acyloxy(C1-6 alkyl) group; R7 and R8 represent —(CH2)p—N(R9)(R10) (p is 1 to 4, and R9 and R10 represent —(CH2)n—COOH (n is 1 to 4))], which is useful for measuring a reactive nitrogen species existing in cells such as nitrogen monoxide or peroxynitrite at high sensitivity over a long period of time.Type: GrantFiled: December 4, 2009Date of Patent: November 25, 2014Assignee: The University of TokyoInventors: Tetsuo Nagano, Yasuteru Urano, Saki Izumi
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Publication number: 20140342384Abstract: A compound represented by the formula (I) (R1 represents a substituent on the benzene ring; R2 represents a monovalent substituent; R3 and R4 represent hydrogen atom, or an alkyl group; R5 and R6 represent an alkyl group, or an aryl group; R7 and R8 represent hydrogen atom, or an alkyl group; R9 and R10 represent hydrogen atom, or a monovalent substituent; and X represents silicon atom, germanium atom, or tin atom), or a salt thereof.Type: ApplicationFiled: February 17, 2012Publication date: November 20, 2014Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Yu Kushida
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Publication number: 20140248654Abstract: Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.Type: ApplicationFiled: September 6, 2012Publication date: September 4, 2014Applicant: THE UNIVERSITY OF TOKYOInventors: Yasuteru Urano, Tetsuo Nagano, Daisuke Asanuma, Kenzo Hirose, Shigeyuki Namiki, Yousuke Takaoka
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Publication number: 20140206992Abstract: Methods for identifying the presence of cancerous cells or tissue by: applying a compound of formula (I), or salts thereof, to a living body, wherein R1 represents hydrogen or the same or different one to four substituents; R2, R3, R4, R5, R6, and R7 independently represent hydrogen, hydroxy, alkyl, or halogen; R8 and R9 independently represent hydrogen or alkyl; and X represents C1-C3 alkylene; and detecting fluorescence emitted by a compound of formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined above; wherein fluorescence emitted by a compound of formula (II) is indicative of the presence of cancerous cells or tissue.Type: ApplicationFiled: January 24, 2014Publication date: July 24, 2014Applicant: THE UNIVERSITY OF TOKYOInventors: Yasuteru URANO, Tetsuo NAGANO, Masayo SAKABE
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Patent number: 8697383Abstract: The object of the present invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme. The present invention provides a compound represented by formula (I) and a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme, which comprises the compound.Type: GrantFiled: May 25, 2011Date of Patent: April 15, 2014Assignees: Mitsubishi Rayon Co., Ltd., The University of TokyoInventors: Yasuteru Urano, Tetsuo Nagano, Tomoe Ohta, Fujio Yu
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Patent number: 8673957Abstract: A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R5 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.Type: GrantFiled: March 21, 2012Date of Patent: March 18, 2014Assignees: Tetsuo Nagano, Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuo Nagano, Yu Gabe, Yasuteru Urano
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Publication number: 20140072990Abstract: The object of the present invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme. The present invention provides a compound represented by formula (I) and a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme, which comprises the compound.Type: ApplicationFiled: September 18, 2013Publication date: March 13, 2014Applicants: The University of Tokyo, Mitsubishi Rayon Co., Ltd.Inventors: Yasuteru URANO, Tetsuo NAGANO, Tomoe OHTA, Fujio YU